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anti-MLANA antibody :: Mouse Melanoma Marker Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS438157
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Melanoma Marker (MLANA), Monoclonal Antibody

★Popular Item★
 Also Known As   

Melanoma Marker (MART-1 + gp100 + Tyrosinase) Mouse Monoclonal Antibody

 Product Synonym Names    Melanoma antigen recognized by T-cells 1 (MART-1), MLAN-A; TYR; PMEL17
 Product Gene Name   

anti-MLANA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605513
 3D Structure    ModBase 3D Structure for Q16655
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 Clonality    Monoclonal
 Isotype    IgG1, IgG2a & IgG2b, kappa
 Clone Number    M2-7C10 + M2-9E3 + HMB45 + T311
 Host    Mouse
 Species Reactivity    Human.
Others not tested
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 Specificity    This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cytoplasmic
 Immunogen    Recombinant hMART-1 protein (M2-7C10; M2-9E3); Recombinant tyrosinase protein (T311); Extract of pigmented melanoma metastases from lymph nodes (HMB45)
 Positive Control    SK-MEL-13 and SK-MEL-19 Melanoma cell lines; Melanomas
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-MLANA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MLANA antibody   

Immunohistochemistry (IHC) Formalin

 Application Notes for anti-MLANA antibody    Immunohistochemistry (Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of anti-MLANA antibody    Formalin-fixed, paraffin-embedded human Melanoma stained with Melanoma Marker Monoclonal Antibody (M2-7C10 + M2-9E3 + T311 + HMB45).
anti-MLANA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MLANA. It may not necessarily be applicable to this product.
 NCBI GI #    5031913
 NCBI GeneID    2315
 NCBI Accession #    NP_005502.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005511.1 [Other Products]
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 UniProt Primary Accession #    Q16655 [Other Products]
 UniProt Secondary Accession #    Q6ICU4 [Other Products]
 UniProt Related Accession #    Q16655 [Other Products]
 Molecular Weight    20-22kDa (doublet) (MART); 70-80kDa (Tyrosinase); 90-100kDa (gp100) [Similar Products]
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 NCBI Official Full Name    melanoma antigen recognized by T-cells 1
 NCBI Official Synonym Full Names    melan-A
 NCBI Official Symbol    MLANA [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    melanoma antigen recognized by T-cells 1
 UniProt Protein Name    Melanoma antigen recognized by T-cells 1
 UniProt Synonym Protein Names   
Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A
 Protein Family    Melanoma antigen recognized by T-cells
 UniProt Gene Name    MLANA [Similar Products]
 UniProt Synonym Gene Names    MART1; MART-1 [Similar Products]
 UniProt Entry Name    MAR1_HUMAN
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 UniProt Comments for MLANA    MLANA: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: endoplasmic reticulum membrane; Golgi apparatus; integral to plasma membrane; melanosome; trans-Golgi network

Molecular Function: protein binding
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Product References and Citations for anti-MLANA antibody

   Chen Y-T, et. al. Proc Natl Acad Sci, USA, 1996, 93:5915-19.Chen Y-T, et. al. Proc. Natl. Acad. Sci. USA, 1995, 92:8125-8129.Gown AM, et. al. American Journal of Pathology, 1986, 123(2):195-203
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 Research Articles on MLANA    1. Suggest MelanA-negative spindle-cell associated melanoma constitutes a distinct inflammatory phenotype correlated with dense infiltration of CD163 macrophages and loss of E-cadherin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MLANA antibodyDiseases associated with anti-MLANA antibody
 Reference Product  PubMed Publications
 PMEL antibody  >131 publications with MLANA and PMEL
 MAGEA3 antibody  >57 publications with MLANA and MAGEA3
 TYR antibody  >17 publications with MLANA and TYR
 WNT5A antibody  >5 publications with MLANA and WNT5A
 ITCH antibody  >2 publications with MLANA and ITCH
 GPR143 antibody  >2 publications with MLANA and GPR143
 NEDD4 antibody  >1 publications with MLANA and NEDD4
 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >400 publications with MLANA and Skin Diseases
 Neoplasm Metastasis Antibodies  >196 publications with MLANA and Neoplasm Metastasis
 Carcinoma Antibodies  >95 publications with MLANA and Carcinoma
 Neoplasms, Experimental Antibodies  >69 publications with MLANA and Neoplasms, Experimental
 Necrosis Antibodies  >55 publications with MLANA and Necrosis
 Disease Models, Animal Antibodies  >53 publications with MLANA and Disease Models, Animal
 Adenocarcinoma Antibodies  >44 publications with MLANA and Adenocarcinoma
 Liver Neoplasms Antibodies  >32 publications with MLANA and Liver Neoplasms
 Kidney Diseases Antibodies  >31 publications with MLANA and Kidney Diseases
 Lung Neoplasms Antibodies  >24 publications with MLANA and Lung Neoplasms
Organs/Tissues associated with anti-MLANA antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >428 publications with MLANA and Skin
 Eye Antibodies  >44 publications with MLANA and Eye
 Kidney Antibodies  >35 publications with MLANA and Kidney
 Brain Antibodies  >22 publications with MLANA and Brain
 Ear Antibodies  >8 publications with MLANA and Ear
 Embryonic Tissue Antibodies  >7 publications with MLANA and Embryonic Tissue
 Mammary Gland Antibodies  >1 publications with MLANA and Mammary Gland
 Heart Antibodies  >1 publications with MLANA and Heart
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