Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow Mer rightarrow Monoclonal Mer  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • S100 calcium binding protein A9 (S100A9) ELISA Kit
 • matrix metallopeptidase 1 (interstitial collagenase) (MMP1) ELISA Kit
 • CEP95 Antibody
 • Cotinine 3 Antibody
 • TREM-1 Antibody
 • acetylcholinesterase (Yt blood group) (ACHE) ELISA Kit
 • VCAM1 Antibody
 • ADH7 Antibody
 • ABCB5 Antibody
 • Polacrilin Potassium Chemical Reference
 • Gonadotropin Releasing Hormone (GNRH1) Antibody
 • MCP-1 Antibody
 • SUMO-1 (SUMO1) Antibody
 • GP ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-Mer antibody :: Rat anti-Mouse Mer Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690563
Testing Data
Unit / Price
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mer, Monoclonal Antibody

★Popular Item★
 Also Known As   

Rat Anti-Mouse Mer

 Product Synonym Names    Mertk; Eyk; Mer; Nyk; nmf12
 Product Gene Name   

anti-Mer antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 2; NC_000002.12 (111898479..112039716). Location: 2q14.1
 OMIM    604705
 3D Structure    ModBase 3D Structure for Q12866
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    (3D07)
 Host    Rat
 Species Reactivity    Mouse
Section Bar
 Specificity    This antibody recognizes mouse Mer in western blot. It has no crossreactivity with rmAxl or rmDtk. Cross reactivity to Mer of other species has not been tested!
 Purity/Purification    Protein G affinity chromatography
 Form/Format    lyophilized
Section Bar
 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with purified recombinant mouse Mer extracellular domain. IgG1 fraction of the culture supernatant was purified by Protein G affinity chromatography.
 Antigen    Recombinant Mouse Mer extracellular domain
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
 Buffer    PBS (sterile)
 Remarks    This antibody was selected for its ability to detect mouse Mer.
Section Bar
 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity. Avoid repeated freeze and thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-Mer antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-Mer antibody

   Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anti-coagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions.
 Applications Tested/Suitable for anti-Mer antibody   

Western Blot (WB), Immunohistochemistry (IHC) - Paraffin

 Application Notes for anti-Mer antibody    1. Western blot: Yes (1:100-1000) 2. Immunohistochemistry (Paraffin): Yes (1:50-200)
Section Bar
 Testing Data of anti-Mer antibody    anti-Mer antibody Testing Data image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for Mer. It may not necessarily be applicable to this product.
 NCBI GI #    66932918
 NCBI GeneID    10461
 NCBI Accession #    NP_006334.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006343.2 [Other Products]
Section Bar
 UniProt Primary Accession #    Q12866 [Other Products]
 UniProt Secondary Accession #    Q9HBB4 [Other Products]
 UniProt Related Accession #    Q12866 [Other Products]
 Molecular Weight    110,249 Da
Table BarTOPTable Bar
 NCBI Official Full Name    tyrosine-protein kinase Mer
 NCBI Official Synonym Full Names    c-mer proto-oncogene tyrosine kinase
 NCBI Official Symbol    MERTK [Similar Products]
 NCBI Official Synonym Symbols   
MER; RP38; c-mer
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase Mer; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK
 UniProt Protein Name    Tyrosine-protein kinase Mer
 UniProt Synonym Protein Names   
Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
 Protein Family    Merlin
 UniProt Gene Name    MERTK [Similar Products]
 UniProt Synonym Gene Names    MER [Similar Products]
 UniProt Entry Name    MERTK_HUMAN
Section Bar
 NCBI Summary for Mer    This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for Mer    Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Ref.11

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure: Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6

By similarity. Interacts with VAV1 in a phosphotyrosine-independent manner. Ref.6 Ref.7 Ref.8 Ref.14

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.

Post-translational modification: Autophosphorylated on Tyr-749, Tyr-753 and Tyr-754 in the activation loop allowing full activity. Autophosphorylated on Tyr-872 leading to recruitment of downstream partners of the signaling cascade such as PLCG2

By similarity. Ref.5

Involvement in disease: Retinitis pigmentosa 38 (RP38) [MIM:613862]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.3

Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.Contains 2 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.
Table BarTOPTable Bar
 Research Articles on Mer    1. MERTK has a role in regulating melanoma cell migration and survival and differentially regulates cell behavior relative to AXL
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-Mer antibodyPathways associated with anti-Mer antibody
 Reference Product  PubMed Publications
 GAS6 antibody  >60 publications with Mer and GAS6
 RPE65 antibody  >14 publications with Mer and RPE65
 GRB2 antibody  >3 publications with Mer and GRB2
 VAV1 antibody  >2 publications with Mer and VAV1
 SEMA4C antibody  >1 publications with Mer and SEMA4C
 DFNB59 antibody  >1 publications with Mer and DFNB59
 DDR1 antibody  >1 publications with Mer and DDR1
 PIK3R1 antibody  >1 publications with Mer and PIK3R1
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-Mer antibodyOrgans/Tissues associated with anti-Mer antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >45 publications with Mer and Neoplasms
 Retinitis Pigmentosa Antibodies  >39 publications with Mer and Retinitis Pigmentosa
 Inflammation Antibodies  >38 publications with Mer and Inflammation
 Disease Models, Animal Antibodies  >31 publications with Mer and Disease Models, Animal
 Death Antibodies  >24 publications with Mer and Death
 Nervous System Diseases Antibodies  >24 publications with Mer and Nervous System Diseases
 Necrosis Antibodies  >21 publications with Mer and Necrosis
 Brain Diseases Antibodies  >13 publications with Mer and Brain Diseases
 Atherosclerosis Antibodies  >13 publications with Mer and Atherosclerosis
 Nerve Degeneration Antibodies  >10 publications with Mer and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >85 publications with Mer and Eye
 Blood Antibodies  >72 publications with Mer and Blood
 Bone Antibodies  >31 publications with Mer and Bone
 Brain Antibodies  >21 publications with Mer and Brain
 Lung Antibodies  >13 publications with Mer and Lung
 Testis Antibodies  >11 publications with Mer and Testis
 Liver Antibodies  >7 publications with Mer and Liver
 Kidney Antibodies  >7 publications with Mer and Kidney
 Muscle Antibodies  >6 publications with Mer and Muscle
 Prostate Antibodies  >6 publications with Mer and Prostate
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions