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anti-LRP1 antibody :: Mouse monoclonal to human 515 kDa LRP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135036 anti-LRP1 antibody
Unit / Price
1 mg  /  $535 +1 FREE 8GB USB
10 mg  /  $3,810 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mouse monoclonal to human 515 kDa LRP (LRP1), Monoclonal Antibody

 Also Known As   

Mouse monoclonal to human 515 kDa LRP

 Product Gene Name   

anti-LRP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (57522282..57607142). Location: 12q13.3
 OMIM    107770
 3D Structure    ModBase 3D Structure for Q07954
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 Clonality    Monoclonal
 Isotype    IgG1 kappa
 Clone Number    8G1
 Host    Host: Mouse; Source: Mouse ascites
 Species Reactivity    Human
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 Purity/Purification    IgG fraction
 Form/Format    Frozen liquid
 Concentration    2.1 mg/ml (lot specific)
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 Immunogen    Full length native protein (purified) (Human).
 Target Information    Recognises the 515kDa alpha chain of Low Density LRP/alpha2 MR.
 Target Molecular Weight    515000
 Buffer    0.05M Sodium Phosphate; 0.15M NaCl; pH 7.4
 Extinction Coefficient    1.36
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 5 years from delivery
Shipping: Ships in Dry Ice.
 Other Notes    Small volumes of anti-LRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-LRP1 antibody

   Monoclonal antibody to human 515 kDa heavy chain of LRP. Useful marker for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD91). Blocks cellular-mediated uptake of alpha 2 macroglobulin trypsin complex by LRP1. Use fibroblast as positive control and human umbilical vein endothelial cells (HUVEC) as negative control. Purified by immobilized Protein A. IgG1 kappa class.
 Product Categories/Family for anti-LRP1 antibody    Receptor Associated Protein (RAP); Monoclonal Antibodies to Human LRP
 Applications Tested/Suitable for anti-LRP1 antibody   

Dot Blot (DB), EM, Flow Cytometry (FC), Immunohistochemistry (IHC) F/P, Immunofluorescence (IF), Western Blot (WB), BL

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NCBI/Uniprot data below describe general gene information for LRP1. It may not necessarily be applicable to this product.
 NCBI GI #    126012562
 NCBI GeneID    4035
 NCBI Accession #    NP_002323.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002332.2 [Other Products]
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 UniProt Primary Accession #    Q07954 [Other Products]
 UniProt Secondary Accession #    Q2PP12; Q8IVG8 [Other Products]
 UniProt Related Accession #    Q07954 [Other Products]
 Molecular Weight    160,000
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 NCBI Official Full Name    prolow-density lipoprotein receptor-related protein 1
 NCBI Official Synonym Full Names    low density lipoprotein receptor-related protein 1
 NCBI Official Symbol    LRP1 [Similar Products]
 NCBI Official Synonym Symbols   
APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R
[Similar Products]
 NCBI Protein Information    prolow-density lipoprotein receptor-related protein 1; LRP-1; type V tgf-beta receptor; apolipoprotein E receptor; alpha-2-macroglobulin receptor; TbetaR-V/LRP-1/IGFBP-3 receptor
 UniProt Protein Name    Prolow-density lipoprotein receptor-related protein 1
 UniProt Synonym Protein Names   
Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor
 Protein Family    Exosome complex protein
 UniProt Gene Name    LRP1 [Similar Products]
 UniProt Synonym Gene Names    A2MR; APR; LRP-1; A2MR; APOER; LRP-85; LRP-515; LRPICD [Similar Products]
 UniProt Entry Name    LRP1_HUMAN
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 NCBI Summary for LRP1    The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]
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 UniProt Comments for LRP1    LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.

Protein type: Cell surface; Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: focal adhesion; cell soma; clathrin-coated vesicle; lysosomal membrane; integral to plasma membrane; dendrite; cytoplasm; nucleolus; plasma membrane; coated pit; receptor complex; endosome

Molecular Function: protein binding; lipoprotein transporter activity; protease binding; protein complex binding; apolipoprotein binding; calcium ion binding; receptor activity

Biological Process: cholesterol metabolic process; phototransduction, visible light; receptor-mediated endocytosis; regulation of phospholipase A2 activity; negative regulation of Wnt receptor signaling pathway; lipoprotein metabolic process; negative regulation of smooth muscle cell migration; positive regulation of protein transport; positive regulation of lipid transport; cell proliferation; lipoprotein transport; regulation of actin cytoskeleton organization and biogenesis; protein kinase C activation; negative regulation of neuron apoptosis; regulation of cholesterol transport; retinoid metabolic process; apoptotic cell clearance; aging
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 Research Articles on LRP1    1. The presence of the G allele at the 25CG (rs35282763) polymorphism of the LRP1 is not associated with a reduced risk of myocardial infarction in a Chinese Han population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LRP1 antibodyPathways associated with anti-LRP1 antibody
 Reference Product  PubMed Publications
 APOE antibody  >62 publications with LRP1 and APOE
 APP antibody  >29 publications with LRP1 and APP
 A2M antibody  >11 publications with LRP1 and A2M
 SRC antibody  >8 publications with LRP1 and SRC
 APBB1 antibody  >8 publications with LRP1 and APBB1
 BACE1 antibody  >7 publications with LRP1 and BACE1
 THBS1 antibody  >7 publications with LRP1 and THBS1
 PDGFB antibody  >6 publications with LRP1 and PDGFB
 LPL antibody  >6 publications with LRP1 and LPL
 FURIN antibody  >3 publications with LRP1 and FURIN
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 PDGFR-beta Signaling Pathway antibodies  PDGFR-beta Signaling Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
Diseases associated with anti-LRP1 antibodyOrgans/Tissues associated with anti-LRP1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >79 publications with LRP1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >56 publications with LRP1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >50 publications with LRP1 and Atherosclerosis
 Neoplasms Antibodies  >47 publications with LRP1 and Neoplasms
 Inflammation Antibodies  >34 publications with LRP1 and Inflammation
 Disease Models, Animal Antibodies  >24 publications with LRP1 and Disease Models, Animal
 Necrosis Antibodies  >20 publications with LRP1 and Necrosis
 Dyslipidemias Antibodies  >12 publications with LRP1 and Dyslipidemias
 Hypercholesterolemia Antibodies  >7 publications with LRP1 and Hypercholesterolemia
 Breast Neoplasms Antibodies  >7 publications with LRP1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >116 publications with LRP1 and Blood
 Brain Antibodies  >113 publications with LRP1 and Brain
 Vascular Antibodies  >74 publications with LRP1 and Vascular
 Muscle Antibodies  >43 publications with LRP1 and Muscle
 Liver Antibodies  >29 publications with LRP1 and Liver
 Nerve Antibodies  >24 publications with LRP1 and Nerve
 Bone Antibodies  >23 publications with LRP1 and Bone
 Lung Antibodies  >15 publications with LRP1 and Lung
 Embryonic Tissue Antibodies  >15 publications with LRP1 and Embryonic Tissue
 Heart Antibodies  >15 publications with LRP1 and Heart
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