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anti-MUC2 antibody :: Mouse anti-Human Mucin 2 / MUC2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245230
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mucin 2 / MUC2, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 996/1] (IgG1) to Human Mucin 2 / MUC2

 Product Synonym Names    Anti-Mucin 2 / MUC2 Antibody (clone 996/1) IHC-plus; MUC2; Intestinal mucin-2; Mucin-like protein; MUC-2; Mucin 2; intestinal/tracheal; Mucin 2; Mucin-2; MLP; SMUC; Human Mucin 2; MUC2
 Product Gene Name   

anti-MUC2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    158370
 3D Structure    ModBase 3D Structure for Q02817
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    996/1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes the human MUC2 mucin, and shows no cross-reactivity with MUC1, MUC3 or MUC4 mucins. In tissue Recognizes colon, liver and prostate tissues strongly. Recognizes malignant colonic mucosa as well as normal mucosa.
 Purity/Purification    Protein G Purified
 Form/Format    PBS, pH 7.4, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    MUC2 tandem repeat peptide.
 Immunogen Type    Synthetic peptide
 Immunogen    Mucin 2 / MUC2 antibody was raised against mUC2 tandem repeat peptide.
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing. Store undiluted.
 Other Notes    Small volumes of anti-MUC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MUC2 antibody

   This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight.
 Product Categories/Family for anti-MUC2 antibody    Family: Mucin
 Applications Tested/Suitable for anti-MUC2 antibody   

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Western Blot (WB)

 Application Notes for anti-MUC2 antibody    IHC-Fr, IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-MUC2 antibody    Anti-MUC2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-MUC2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MUC2. It may not necessarily be applicable to this product.
 NCBI GI #    116284392
 NCBI GeneID    4583
 NCBI Accession #    NP_002448.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002457.2 [Other Products]
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 UniProt Primary Accession #    Q02817 [Other Products]
 UniProt Secondary Accession #    Q14878 [Other Products]
 UniProt Related Accession #    Q02817 [Other Products]
 Molecular Weight    540,300 Da
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 NCBI Official Full Name    mucin-2
 NCBI Official Synonym Full Names    mucin 2, oligomeric mucus/gel-forming
 NCBI Official Symbol    MUC2 [Similar Products]
 NCBI Official Synonym Symbols   
MLP; SMUC; MUC-2
[Similar Products]
 NCBI Protein Information    mucin-2; intestinal mucin-2; mucin-like protein; mucin 2, intestinal/tracheal
 UniProt Protein Name    Mucin-2
 UniProt Synonym Protein Names   
Intestinal mucin-2
 Protein Family    Mucin
 UniProt Gene Name    MUC2 [Similar Products]
 UniProt Synonym Gene Names    SMUC; MUC-2 [Similar Products]
 UniProt Entry Name    MUC2_HUMAN
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 NCBI Summary for MUC2    This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MUC2    MUC2: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

Protein type: Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: Golgi lumen

Molecular Function: protein binding

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; maintenance of gastrointestinal epithelium; post-translational protein modification
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 Research Articles on MUC2    1. The results indicated that the DNA methylation status of MUC1, MUC2 and MUC4 in pancreatic juice matched with the mucin expression in tissue.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MUC2 antibodyPathways associated with anti-MUC2 antibody
 Reference Product  PubMed Publications
 MUC1 antibody  >559 publications with MUC2 and MUC1
 MUC4 antibody  >209 publications with MUC2 and MUC4
 MUC7 antibody  >66 publications with MUC2 and MUC7
 MUC17 antibody  >13 publications with MUC2 and MUC17
 MUC3A antibody  >10 publications with MUC2 and MUC3A
 MUC15 antibody  >7 publications with MUC2 and MUC15
 MUC12 antibody  >7 publications with MUC2 and MUC12
 MUC20 antibody  >6 publications with MUC2 and MUC20
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 O-linked Glycosylation Of Mucins Pathway antibodies  O-linked Glycosylation Of Mucins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Termination Of O-glycan Biosynthesis Pathway antibodies  Termination Of O-glycan Biosynthesis Pathway Diagram
 Vibrio Cholerae Infection Pathway antibodies  Vibrio Cholerae Infection Pathway Diagram
 Vibrio Cholerae Infection Pathway antibodies  Vibrio Cholerae Infection Pathway Diagram
Diseases associated with anti-MUC2 antibodyOrgans/Tissues associated with anti-MUC2 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >582 publications with MUC2 and Adenocarcinoma
 Intestinal Neoplasms Antibodies  >543 publications with MUC2 and Intestinal Neoplasms
 Pancreatic Neoplasms Antibodies  >166 publications with MUC2 and Pancreatic Neoplasms
 Adenoma Antibodies  >153 publications with MUC2 and Adenoma
 Inflammation Antibodies  >135 publications with MUC2 and Inflammation
 Neoplasm Metastasis Antibodies  >97 publications with MUC2 and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >68 publications with MUC2 and Liver Neoplasms
 Precancerous Conditions Antibodies  >68 publications with MUC2 and Precancerous Conditions
 Hyperplasia Antibodies  >64 publications with MUC2 and Hyperplasia
 Necrosis Antibodies  >59 publications with MUC2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >548 publications with MUC2 and Intestine
 Stomach Antibodies  >317 publications with MUC2 and Stomach
 Blood Antibodies  >88 publications with MUC2 and Blood
 Muscle Antibodies  >53 publications with MUC2 and Muscle
 Kidney Antibodies  >25 publications with MUC2 and Kidney
 Thyroid Antibodies  >16 publications with MUC2 and Thyroid
 Ascites Antibodies  >10 publications with MUC2 and Ascites
 Brain Antibodies  >8 publications with MUC2 and Brain
 Placenta Antibodies  >2 publications with MUC2 and Placenta
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