NP_002449.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
mucin-5B
NCBI Official Synonym Full Names
mucin 5B, oligomeric mucus/gel-forming
NCBI Protein Information
mucin-5B
UniProt Protein Name
Mucin-5B
UniProt Synonym Protein Names
Cervical mucin; High molecular weight salivary mucin MG1; Mucin-5 subtype B, tracheobronchial; Sublingual gland mucin
UniProt Synonym Gene Names
NCBI Summary for MUC5B
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]
UniProt Comments for MUC5B
MUC5B: Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Defects in MUC5B are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF). Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741).
Protein type: Cell adhesion; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: extracellular space; Golgi lumen; intracellular membrane-bound organelle; plasma membrane
Molecular Function: protein binding
Biological Process: O-glycan processing; stimulatory C-type lectin receptor signaling pathway
Disease: Pulmonary Fibrosis, Idiopathic
Research Articles on MUC5B
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Pathways associated with anti-MUC5B antibody
Diseases associated with anti-MUC5B antibody
Organs/Tissues associated with anti-MUC5B antibody
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