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anti-MBP antibody :: Mouse Myelin Basic Protein / MBP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245505
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myelin Basic Protein / MBP, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone V/h5] (IgG1) to Human Myelin Basic Protein / MBP

 Product Synonym Names    Anti-Myelin Basic Protein / MBP Antibody (N-Terminus, clone V/h5) IHC-plus; MBP; Myelin A1 protein; Myelin basic protein; Human Myelin Basic Protein; MBP
 Product Gene Name   

anti-MBP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    159430
 3D Structure    ModBase 3D Structure for P02686
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    V/h5
 Host    Mouse
 Species Reactivity    Bovine, Guinea pig, Human, Rabbit, Sheep
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 Specificity    Recognizes predominantly residues 45-91
 Purity/Purification    Protein A Purified
 Form/Format    PBS, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide corresponding to the amino acids 45 - 91 of the native molecule conjugated to BSA. N-terminal fragment of human MBP (residues 1-118) produced by BNPS-skatole cleavage of pure human MBP, injected coupled to BSA using carbodiimide.
 Immunogen Type    Synthetic peptide
 Immunogen    Myelin Basic Protein / MBP antibody was raised against synthetic peptide corresponding to the amino acids 45 - 91 of the native molecule conjugated to BSA. N-terminal fragment of human MBP (residues 1-118) produced by BNPS-skatole cleavage of pure human MBP, injected coupled to BSA using carbodiimide.
 Antigen Modification    N-Terminus
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-MBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MBP antibody

   The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis.
 Applications Tested/Suitable for anti-MBP antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA), Radioimmunoassay (RIA)

 Application Notes for anti-MBP antibody    ELISA, IHC-P (10 ug/ml), RIA
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-MBP antibody    Anti-Myelin Basic Protein antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-MBP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MBP antibody    Anti-Myelin Basic Protein antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-MBP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MBP. It may not necessarily be applicable to this product.
 NCBI GI #    4505123
 NCBI GeneID    4155
 NCBI Accession #    NP_002376.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002385.2 [Other Products]
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 UniProt Primary Accession #    P02686 [Other Products]
 UniProt Secondary Accession #    Q15337; Q15338; Q15339; Q15340; A4FU54; A6NI84; A8MY86; A8MYL4; B3KY66; B7ZKS2; B7ZKS4 [Other Products]
 UniProt Related Accession #    P02686 [Other Products]
 Molecular Weight    17,343 Da
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 NCBI Official Full Name    myelin basic protein isoform 2
 NCBI Official Synonym Full Names    myelin basic protein
 NCBI Official Symbol    MBP [Similar Products]
 NCBI Protein Information    Golli-MBP; myelin basic protein; myelin A1 protein; myelin membrane encephalitogenic protein
 UniProt Protein Name    Myelin basic protein
 UniProt Synonym Protein Names   
Myelin A1 protein; Myelin membrane encephalitogenic protein
 Protein Family    Myelin basic protein
 UniProt Gene Name    MBP [Similar Products]
 UniProt Synonym Gene Names    MBP [Similar Products]
 UniProt Entry Name    MBP_HUMAN
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 NCBI Summary for MBP    The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MBP    MBP: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 18q23

Cellular Component: compact myelin; internode region of axon; cell soma; plasma membrane; nucleus

Molecular Function: protein binding; structural constituent of myelin sheath; protease binding

Biological Process: response to mercury ion; myelination; synaptic transmission; central nervous system development; substantia nigra development; response to toxin; negative regulation of axonogenesis; immune response; axon ensheathment; response to progesterone stimulus; aging
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 Research Articles on MBP    1. data reveal the first case of a pathophysiologically important autoantigen as a ubiquitin-independent substrate of the 26S proteasome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MBP antibodyDiseases associated with anti-MBP antibody
 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2671 publications with MBP and Nervous System Diseases
 Demyelinating Diseases Antibodies  >1965 publications with MBP and Demyelinating Diseases
 Brain Diseases Antibodies  >1719 publications with MBP and Brain Diseases
 Disease Models, Animal Antibodies  >1381 publications with MBP and Disease Models, Animal
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >1183 publications with MBP and Encephalomyelitis, Autoimmune, Experimental
 Cardiovascular Diseases Antibodies  >684 publications with MBP and Cardiovascular Diseases
 Inflammation Antibodies  >486 publications with MBP and Inflammation
 Hypertension Antibodies  >410 publications with MBP and Hypertension
 Necrosis Antibodies  >258 publications with MBP and Necrosis
 Heart Diseases Antibodies  >189 publications with MBP and Heart Diseases
Organs/Tissues associated with anti-MBP antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3613 publications with MBP and Blood
 Brain Antibodies  >1901 publications with MBP and Brain
 Nerve Antibodies  >1409 publications with MBP and Nerve
 Heart Antibodies  >683 publications with MBP and Heart
 Spinal Cord Antibodies  >671 publications with MBP and Spinal Cord
 Kidney Antibodies  >267 publications with MBP and Kidney
 Muscle Antibodies  >245 publications with MBP and Muscle
 Spleen Antibodies  >239 publications with MBP and Spleen
 Lymph Node Antibodies  >238 publications with MBP and Lymph Node
 Lymph Antibodies  >238 publications with MBP and Lymph
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