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anti-Mbp antibody :: Mouse anti-Human Myelin Basic Protein Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS609747 anti-Mbp antibody
Unit / Price
0.05 mg  /  $435 +1 FREE 8GB USB
0.1 mg  /  $665 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myelin Basic Protein (Mbp), Monoclonal Antibody

 Also Known As   

Myelin Basic Protein, phosphorylated (MBP)

 Product Synonym Names    Anti -Myelin Basic Protein, phosphorylated (MBP)
 Product Gene Name   

anti-Mbp antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 18; NC_005117.2 (78943608..79057329). Location: 18q
 3D Structure    ModBase 3D Structure for P02688
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    0.T.90
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human phosphorylated MBP and most common vertebrate species.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide before the addition of glycerol to 30%.
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 Immunogen    Synthetic peptide corresponding to the human myelin basic protein sequence phosphorylated at Thr98 (tuberculin coupled).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-Mbp antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Mbp antibody

   Myelin basic protein (MBP) is a single-chain, flexible polypeptide of about 18.5kD existing in its natural environment as an extrinsic and loosely bound component of the cytoplasmic portion of the myelin membrane sandwich. Ultrastructural immunocytochemistry with anti-myelin basic protein has shown that MBP is localized in the compact myelin sheath. MBP has not been demonstrated in rough endoplasmic reticulum, lysosomes or any other cytoplasmic organelles. MBP serves as a marker for oligodendrocytes and Schwann cells. MBP is also a marker for malignant schwannomas and appears to play a significant role in the etiology of multiple sclerosis and experimental autoimmune encephalomyelitis.
 Product Categories/Family for anti-Mbp antibody    Antibodies; Abs to Myelin
 Applications Tested/Suitable for anti-Mbp antibody   

Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-Mbp antibody    Suitable for use in Immunoblot, Protein Kinase Assay and Immunocytochemistry.
Dilution: Immunoblot: 0.5-2ug/ml. Strongly detects phosphorylated MBP. Note: Some preparations of MBP contain basal levels of phosphorylated MBP, which are detected by the M9758-05.
Protein Kinase Assay: Phosphorylated MBP was detected in a direct kinase assay using non-radioactive MAP Kinase Assay Kit, BioAssay (M2353) and usign MAP Kinase Immunoprecipitation Kinase Assay Kit, BioAssay (M2353-50).
Immunocytochemistry: Reported by an indepeend lab (3).
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NCBI/Uniprot data below describe general gene information for Mbp. It may not necessarily be applicable to this product.
 NCBI GI #    70166270
 NCBI GeneID    24547
 NCBI Accession #    NP_001020465.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025294.1 [Other Products]
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 UniProt Primary Accession #    P02688 [Other Products]
 UniProt Secondary Accession #    Q505J1; Q8R4K6; Q9Z1J4; Q9Z1J5; Q9Z1J6 [Other Products]
 UniProt Related Accession #    P02688; Q5XFW1 [Other Products]
 Molecular Weight    21,502 Da [Similar Products]
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 NCBI Official Full Name    myelin basic protein isoform 4
 NCBI Official Synonym Full Names    myelin basic protein
 NCBI Official Symbol    Mbp [Similar Products]
 NCBI Official Synonym Symbols   
Mbps
[Similar Products]
 NCBI Protein Information    Golli-Mbp; myelin basic protein; MBP S; myelin basic protein S; myelin basic protein Golli-mbp; Golli-Mbp; myelin basic protein; myelin basic protein S
 UniProt Protein Name    Myelin basic protein S
 Protein Family    Myelin basic protein
 UniProt Gene Name    Mbp [Similar Products]
 UniProt Entry Name    MBP_RAT
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 NCBI Summary for Mbp    The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq]
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 UniProt Comments for Mbp    MBP: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Cellular Component: compact myelin; internode region of axon; cell projection; cell soma; plasma membrane; myelin sheath

Molecular Function: protein binding; structural constituent of myelin sheath; protease binding

Biological Process: myelination; response to mercury ion; substantia nigra development; response to toxin; negative regulation of axonogenesis; response to progesterone stimulus; aging
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 Research Articles on Mbp    1. MBP synthesis is regulated by hnRNP-K and integrin activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Mbp antibodyDiseases associated with anti-Mbp antibody
 Products by Pathway  Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
 Disease Name  Pubmed Publications
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >1100 publications with Mbp and Encephalomyelitis, Autoimmune, Experimental
 Inflammation Antibodies  >399 publications with Mbp and Inflammation
 Neoplasms Antibodies  >389 publications with Mbp and Neoplasms
 Mental Disorders Antibodies  >129 publications with Mbp and Mental Disorders
 Neurodegenerative Diseases Antibodies  >89 publications with Mbp and Neurodegenerative Diseases
 Leukemia Antibodies  >80 publications with Mbp and Leukemia
 Intestinal Diseases Antibodies  >78 publications with Mbp and Intestinal Diseases
 Glioma Antibodies  >68 publications with Mbp and Glioma
 Pain Antibodies  >61 publications with Mbp and Pain
 Edema Antibodies  >51 publications with Mbp and Edema
Organs/Tissues associated with anti-Mbp antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1551 publications with Mbp and Brain
 Kidney Antibodies  >233 publications with Mbp and Kidney
 Spleen Antibodies  >224 publications with Mbp and Spleen
 Muscle Antibodies  >213 publications with Mbp and Muscle
 Eye Antibodies  >98 publications with Mbp and Eye
 Dorsal Root Ganglion Antibodies  >35 publications with Mbp and Dorsal Root Ganglion
 Placenta Antibodies  >30 publications with Mbp and Placenta
 Ovary Antibodies  >28 publications with Mbp and Ovary
 Prostate Antibodies  >24 publications with Mbp and Prostate
 Adrenal Gland Antibodies  >20 publications with Mbp and Adrenal Gland
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