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anti-S100A9 antibody :: Mouse anti-Human Myeloid-Related Proteins 14 (MRP14) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS439318
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myeloid-Related Proteins 14 (MRP14) (S100A9), Monoclonal Antibody

★Popular Item★
 Also Known As   

Myeloid-Related Proteins 14 (MRP14) (Macrophage Marker) Mouse Monoclonal Antibody

 Product Synonym Names    S100-A9; MRP14; calgranulin-B; calprotectin L1H subunit; leukocyte L1 complex heavy chain; migration inhibitory factor-related protein 14; S100 calcium-binding protein A9 (calgranulin B)
 Product Gene Name   

anti-S100A9 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123886
 3D Structure    ModBase 3D Structure for P06702
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 Clonality    Monoclonal
 Isotype    IgM, kappa
 Clone Number    MRP14/840
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes a protein of14kDa, identified as MRP-14 (also known as Calgranulin B or S100AA9). It comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. It is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity, like inflammatory bowel disease. Granulocytes terminate their existence after transmigration through the intestinal wall. Therefore, it is also detectable in feces. Elevated levels have been observed in body fluids such as plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions. This MAb reacts with neutrophils, monocytes, and macrophages, and has been shown as an important marker for identifying macrophages in tissue sections.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
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 Cellular Localization    Cytoplasmic
 Immunogen    Recombinant human MRP14 protein
 Hu-Chromosome Location    1q21
 Positive Control    Tonsil, lymph node, or spleen
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-S100A9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-S100A9 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-S100A9 antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed. Not suitable for frozen tissues.) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of anti-S100A9 antibody    Formalin-fixed, paraffin-embedded human Tonsil stained with MRP14 Monoclonal Antibody (MRP14/840)
anti-S100A9 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for S100A9. It may not necessarily be applicable to this product.
 NCBI GI #    4506773
 NCBI GeneID    6280
 NCBI Accession #    NP_002956.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002965.3 [Other Products]
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 UniProt Primary Accession #    P06702 [Other Products]
 UniProt Secondary Accession #    Q6FGA1; Q9NYM0; Q9UCJ1; D3DV36 [Other Products]
 UniProt Related Accession #    P06702 [Other Products]
 Molecular Weight    14kDa
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 NCBI Official Full Name    protein S100-A9
 NCBI Official Synonym Full Names    S100 calcium binding protein A9
 NCBI Official Symbol    S100A9 [Similar Products]
 NCBI Official Synonym Symbols   
MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387
[Similar Products]
 NCBI Protein Information    protein S100-A9
 UniProt Protein Name    Protein S100-A9
 UniProt Synonym Protein Names   
Calgranulin-B; Calprotectin L1H subunit; Leukocyte L1 complex heavy chain; Migration inhibitory factor-related protein 14; MRP-14; p14; S100 calcium-binding protein A9
 Protein Family    Protein
 UniProt Gene Name    S100A9 [Similar Products]
 UniProt Synonym Gene Names    CAGB; CFAG; MRP14; MRP-14; p14 [Similar Products]
 UniProt Entry Name    S10A9_HUMAN
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 NCBI Summary for S100A9    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014]
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 UniProt Comments for S100A9    S100A9: a calcium-binding regulatory protein of the S-100 family expressed by macrophages in acutely inflammated tissues and in chronic inflammations. May be an inhibitor of protein kinases. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermediate filaments in monocytes and epithelial cells. Interacts with CEACAM3 in a calcium-dependent manner.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoskeleton; cytosol; extracellular region; extracellular space; nucleus; plasma membrane

Molecular Function: arachidonic acid binding; calcium ion binding; microtubule binding; protein binding; RAGE receptor binding; signal transducer activity; zinc ion binding

Biological Process: activation of NF-kappaB transcription factor; autophagy; caspase activation; cell-cell signaling; chemokine production; cytokine production; defense response to bacterium; defense response to fungus; inflammatory response; leukocyte migration during inflammatory response; neutrophil chemotaxis; positive regulation of cell growth; positive regulation of inflammatory response; regulation of cytoskeleton organization and biogenesis; sequestering of zinc ion
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Product References and Citations for anti-S100A9 antibody

   Kong, J.P., et al. 2004. Loss of myeloid-related proteins 8 and myeloid- related proteins 14 expression in human esophageal squamous cell carcinoma correlates with poor differentiation. World J. Gastroenterol. 10: 1093-1097
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 Research Articles on S100A9    1. Urinary calprotectin concentrations start rising within 2 hours after ischaemia/reperfusion-induced kidney injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-S100A9 antibodyDiseases associated with anti-S100A9 antibody
 Reference Product  PubMed Publications
 S100A8 antibody  >894 publications with S100A9 and S100A8
 TLR4 antibody  >75 publications with S100A9 and TLR4
 MYD88 antibody  >11 publications with S100A9 and MYD88
 MIF antibody  >4 publications with S100A9 and MIF
 PARP1 antibody  >2 publications with S100A9 and PARP1
 TIRAP antibody  >2 publications with S100A9 and TIRAP
 LY96 antibody  >2 publications with S100A9 and LY96
 MYB antibody  >1 publications with S100A9 and MYB
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >475 publications with S100A9 and Inflammation
 Disease Models, Animal Antibodies  >130 publications with S100A9 and Disease Models, Animal
 Nervous System Diseases Antibodies  >90 publications with S100A9 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >88 publications with S100A9 and Cardiovascular Diseases
 Necrosis Antibodies  >86 publications with S100A9 and Necrosis
 Brain Diseases Antibodies  >55 publications with S100A9 and Brain Diseases
 Fibrosis Antibodies  >55 publications with S100A9 and Fibrosis
 Neoplasms, Experimental Antibodies  >39 publications with S100A9 and Neoplasms, Experimental
 Heart Diseases Antibodies  >37 publications with S100A9 and Heart Diseases
 Breast Neoplasms Antibodies  >35 publications with S100A9 and Breast Neoplasms
Organs/Tissues associated with anti-S100A9 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >538 publications with S100A9 and Blood
 Skin Antibodies  >128 publications with S100A9 and Skin
 Lung Antibodies  >121 publications with S100A9 and Lung
 Vascular Antibodies  >100 publications with S100A9 and Vascular
 Brain Antibodies  >66 publications with S100A9 and Brain
 Bone Antibodies  >63 publications with S100A9 and Bone
 Liver Antibodies  >61 publications with S100A9 and Liver
 Bone Marrow Antibodies  >49 publications with S100A9 and Bone Marrow
 Kidney Antibodies  >48 publications with S100A9 and Kidney
 Muscle Antibodies  >48 publications with S100A9 and Muscle
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