NP_060647.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
NEDD4-binding protein 2
NCBI Official Synonym Full Names
NEDD4 binding protein 2
NCBI Official Synonym Symbols
NCBI Protein Information
NEDD4-binding protein 2; BCL-3-binding protein
UniProt Protein Name
NEDD4-binding protein 2
UniProt Synonym Protein Names
BCL-3-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
N4BP2_HUMAN
NCBI Summary for N4BP2
This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. [provided by RefSeq, Jul 2008]
UniProt Comments for N4BP2
Nedd4-BP2: Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.-.-.-; Hydrolase; Kinase, other
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: cytosol
Molecular Function: protein binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; endonuclease activity; ATP binding
Biological Process: phosphorylation
Research Articles on N4BP2
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Products associated with anti-N4BP2 antibody
Diseases associated with anti-N4BP2 antibody
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