NP_000704.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens biliverdin reductase B (BLVRB), mRNA
NCBI Official Synonym Full Names
biliverdin reductase B
NCBI Protein Information
flavin reductase (NADPH); flavin reductase (NADPH); BVR-B; FR; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; biliverdin reductase B (flavin reductase (NADPH)); biliverdin-IX beta-reductase; epididymis secretory protein Li 10; green heme-binding protein; short chain dehydrogenase/reductase family 43U, member 1
UniProt Entry Name
BLVRB_HUMAN
NCBI Summary for NADPH
The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]
UniProt Comments for NADPH
BLVRB: Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
Protein type: EC 1.3.1.24; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.5.1.30; Oxidoreductase
Chromosomal Location of Human Ortholog: 19q13.1-q13.2
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol
Molecular Function: flavin reductase activity; biliverdin reductase activity
Biological Process: heme catabolic process; porphyrin metabolic process
Research Articles on NADPH
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Pathways associated with anti-NADPH antibody
Diseases associated with anti-NADPH antibody
Organs/Tissues associated with anti-NADPH antibody
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