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anti-NLRP3 antibody :: Mouse anti-Human NALP3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS604215 anti-NLRP3 antibody
Unit / Price
0.1 mg  /  $620 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NALP3 (NLRP3), Monoclonal Antibody

 Also Known As   

NALP3 (NACHT-, LRR- and PYD-Containing Protein 3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein, PYPAF1, PYRIN-Containing APAF1-like Protein 1, CIAS1)

 Product Synonym Names    Anti -NALP3 (NACHT-, LRR- and PYD-Containing Protein 3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein, PYPAF1, PYRIN-Containing APAF1-like Protein 1, CIAS1)
 Product Gene Name   

anti-NLRP3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (247579458..247612410). Location: 1q44
 3D Structure    ModBase 3D Structure for Q65Z67
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    6D600
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes endogenous human NALP3.
 Purity/Purification    Highly Purified
Purified from concentrated hybridoma tissue culture supernatant. 95% (SDS-PAGE).
 Form/Format    Supplied as a liquid in PBS containing 0.02% sodium azide.
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 Immunogen    Recombinant human NALP3 (NACHT-, LRR- and PYD-containing protein 3) (pyrin domain).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-NLRP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NLRP3 antibody    Antibodies; Abs to Disease Markers
 Applications Tested/Suitable for anti-NLRP3 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-NLRP3 antibody    Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry.
Dilution: Immunohistochemistry: frozen sections
Immunoprecipitation: 1:50
Western Blot: 1:1000
Optimal dilutions to be determined by researcher.
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NCBI/Uniprot data below describe general gene information for NLRP3. It may not necessarily be applicable to this product.
 NCBI GI #    188536002
 NCBI GeneID    114548
 NCBI Accession #    NP_001120934.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001127462.2 [Other Products]
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 UniProt Primary Accession #    Q65Z67 [Other Products]
 UniProt Related Accession #    Q65Z67; Q96P20 [Other Products]
 Molecular Weight    6,129 Da [Similar Products]
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 NCBI Official Full Name    NACHT, LRR and PYD domains-containing protein 3 isoform d
 NCBI Official Synonym Full Names    NLR family, pyrin domain containing 3
 NCBI Official Symbol    NLRP3 [Similar Products]
 NCBI Official Synonym Symbols   
AII; AVP; FCU; MWS; FCAS; CIAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL; FLJ95925
[Similar Products]
 NCBI Protein Information    NACHT, LRR and PYD domains-containing protein 3; cryopyrin; OTTHUMP00000038408; OTTHUMP00000038409; OTTHUMP00000038410; OTTHUMP00000038411; OTTHUMP00000230825; caterpiller protein 1.1; PYRIN-containing APAF1-like protein 1; NACHT, LRR and PYD containing protein 3; cold autoinflammatory syndrome 1 protein; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
 UniProt Protein Name    AII/AVP receptor-like
 Protein Family    NACHT, LRR and PYD domains-containing protein
 UniProt Gene Name    CIAS1 [Similar Products]
 UniProt Entry Name    Q65Z67_HUMAN
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 NCBI Summary for NLRP3    This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq]
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 UniProt Comments for NLRP3    NLRP3: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1); also known as familial cold urticaria. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. Defects in NLRP3 are a cause of Muckle-Wells syndrome (MWS); also known as urticaria-deafness-amyloidosis syndrome. MWS is a hereditary periodic fever syndrome characterized by fever, chronic recurrent urticaria, arthralgias, progressive sensorineural deafness, and reactive renal amyloidosis. The disease may be severe if generalized amyloidosis occurs. Defects in NLRP3 are the cause of chronic infantile neurologic cutaneous and articular syndrome (CINCA); also known as neonatal onset multisystem inflammatory disease (NOMID). CINCA is a rare congenital inflammatory disorder characterized by a triad of neonatal onset of cutaneous symptoms, chronic meningitis and joint manifestations with recurrent fever and inflammation. Belongs to the NLRP family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; peptidoglycan binding; ATP binding

Biological Process: caspase activation; apoptosis; negative regulation of acute inflammatory response; positive regulation of caspase activity; interleukin-1 beta production; defense response; negative regulation of NF-kappaB import into nucleus; positive regulation of interleukin-1 beta secretion; signal transduction; protein oligomerization; activation of NF-kappaB transcription factor; negative regulation of interleukin-1 beta secretion; inhibition of NF-kappaB transcription factor; negative regulation of inflammatory response; innate immune response; interleukin-18 production; interleukin-1 secretion; inflammatory response; detection of biotic stimulus; defense response to virus

Disease: Cinca Syndrome; Familial Cold Autoinflammatory Syndrome 1; Muckle-wells Syndrome
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 Research Articles on NLRP3    1. [review] A growing body of evidence supports a potential role of the Nlrp3 inflammasome in the development of multiple aspects of the metabolic syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NLRP3 antibodyPathways associated with anti-NLRP3 antibody
 Reference Product  PubMed Publications
 PYCARD antibody  >52 publications with NLRP3 and PYCARD
 NLRC4 antibody  >38 publications with NLRP3 and NLRC4
 CARD8 antibody  >11 publications with NLRP3 and CARD8
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Innate Immunity Signaling Pathway antibodies  Innate Immunity Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
Diseases associated with anti-NLRP3 antibodyOrgans/Tissues associated with anti-NLRP3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >408 publications with NLRP3 and Inflammation
 MUCKLE-WELLS SYNDROME Antibodies  >127 publications with NLRP3 and MUCKLE-WELLS SYNDROME
 Necrosis Antibodies  >85 publications with NLRP3 and Necrosis
 Cryopyrin-Associated Periodic Syndromes Antibodies  >78 publications with NLRP3 and Cryopyrin-Associated Periodic Syndromes
 Death Antibodies  >78 publications with NLRP3 and Death
 FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1 Antibodies  >77 publications with NLRP3 and FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1
 Disease Models, Animal Antibodies  >40 publications with NLRP3 and Disease Models, Animal
 Lung Diseases Antibodies  >36 publications with NLRP3 and Lung Diseases
 Cardiovascular Diseases Antibodies  >27 publications with NLRP3 and Cardiovascular Diseases
 Pain Antibodies  >27 publications with NLRP3 and Pain
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >141 publications with NLRP3 and Blood
 Lung Antibodies  >27 publications with NLRP3 and Lung
 Bone Marrow Antibodies  >22 publications with NLRP3 and Bone Marrow
 Brain Antibodies  >7 publications with NLRP3 and Brain
 Intestine Antibodies  >6 publications with NLRP3 and Intestine
 Pancreas Antibodies  >3 publications with NLRP3 and Pancreas
 Connective Tissue Antibodies  >2 publications with NLRP3 and Connective Tissue
 Thymus Antibodies  >1 publications with NLRP3 and Thymus
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