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anti-NCAM antibody :: Mouse NCAM / CD56 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245133
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NCAM / CD56, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone MEM-188] (IgG2a) to Human NCAM / CD56

 Product Synonym Names    Anti-NCAM / CD56 Antibody (clone MEM-188) IHC-plus; NCAM1; CD56; CD56 antigen; MSK39; NCAM-1; N-CAM-1; NCAM; Human NCAM; CD56
 Product Gene Name   

anti-NCAM antibody

[Similar Products]
 Product Synonym Gene Name    CD56; NCAM1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    116930
 3D Structure    ModBase 3D Structure for P13591
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    MEM-188
 Host    Mouse
 Species Reactivity    Bovine, Human, Pig
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 Specificity    KG-1 human acute myelogenous leukemia cell line
 Purity/Purification    Affinity Purified
 Form/Format    Phosphate-buffered solution, pH 7.2, 0.09% sodium azide.
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Cells.
 Immunogen    NCAM / CD56 antibody was raised against cells.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-NCAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NCAM antibody    Family: Immunoglobulin
 Applications Tested/Suitable for anti-NCAM antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)

 Application Notes for anti-NCAM antibody    Flo, IHC-P (10 ug/ml), IP, WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-NCAM antibody    Anti-CD56 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-NCAM antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-NCAM antibody    Human peripheral blood lymphocytes stained with purified MEM-188, followed by anti-mouse IgGs FITC
anti-NCAM antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for NCAM. It may not necessarily be applicable to this product.
 NCBI GI #    94420689
 NCBI GeneID    4684
 NCBI Accession #    NP_000606.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000615.6 [Other Products]
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 UniProt Primary Accession #    P13591 [Other Products]
 UniProt Secondary Accession #    P13592; P13593; Q05C58; Q15829; Q16180; Q16209; Q59FL7; Q86X47; Q96CJ3; A8K8T8 [Other Products]
 UniProt Related Accession #    P13591 [Other Products]
 Molecular Weight    40,760 Da
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 NCBI Official Full Name    neural cell adhesion molecule 1 isoform 1
 NCBI Official Synonym Full Names    neural cell adhesion molecule 1
 NCBI Official Symbol    NCAM1 [Similar Products]
 NCBI Official Synonym Symbols   
CD56; NCAM; MSK39
[Similar Products]
 NCBI Protein Information    neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; antigen recognized by monoclonal antibody 5.1H11
 UniProt Protein Name    Neural cell adhesion molecule 1
 UniProt Synonym Protein Names   
CD_antigen: CD56
 UniProt Gene Name    NCAM1 [Similar Products]
 UniProt Synonym Gene Names    NCAM; N-CAM-1; NCAM-1 [Similar Products]
 UniProt Entry Name    NCAM1_HUMAN
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 NCBI Summary for NCAM    This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
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 UniProt Comments for NCAM    NCAM1: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: Golgi membrane; cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: identical protein binding

Biological Process: axon guidance; extracellular matrix organization and biogenesis; cytokine and chemokine mediated signaling pathway; cell adhesion
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 Research Articles on NCAM    1. NCAM expression in myelinating Schwann cells is indicative of early Schwann cell abnormalities.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NCAM antibodyDiseases associated with anti-NCAM antibody
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >973 publications with NCAM and Nervous System Diseases
 Brain Diseases Antibodies  >534 publications with NCAM and Brain Diseases
 Necrosis Antibodies  >272 publications with NCAM and Necrosis
 Disease Models, Animal Antibodies  >254 publications with NCAM and Disease Models, Animal
 Inflammation Antibodies  >235 publications with NCAM and Inflammation
 Lung Neoplasms Antibodies  >223 publications with NCAM and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >219 publications with NCAM and Cardiovascular Diseases
 Congenital Abnormalities Antibodies  >193 publications with NCAM and Congenital Abnormalities
 Liver Diseases Antibodies  >178 publications with NCAM and Liver Diseases
 Neoplasm Invasiveness Antibodies  >146 publications with NCAM and Neoplasm Invasiveness
Organs/Tissues associated with anti-NCAM antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2701 publications with NCAM and Brain
 Blood Antibodies  >2475 publications with NCAM and Blood
 Nerve Antibodies  >1723 publications with NCAM and Nerve
 Embryonic Tissue Antibodies  >831 publications with NCAM and Embryonic Tissue
 Muscle Antibodies  >562 publications with NCAM and Muscle
 Bone Antibodies  >523 publications with NCAM and Bone
 Skin Antibodies  >375 publications with NCAM and Skin
 Vascular Antibodies  >363 publications with NCAM and Vascular
 Eye Antibodies  >337 publications with NCAM and Eye
 Lung Antibodies  >325 publications with NCAM and Lung
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