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anti-NCSTN antibody :: Mouse anti-Human, Mouse NCSTN / Nicastrin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245353
Unit / Price
0.05 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NCSTN / Nicastrin, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone AT3B2] (IgG2b,k) to Human NCSTN / Nicastrin

 Product Synonym Names    Anti-NCSTN / Nicastrin Antibody (clone AT3B2) IHC-plus; NCSTN; Anterior pharynx-defective 2; ATAG1874; KIAA0253; Nicastrin; APH2; RP11-517F10.1; Human NCSTN; Nicastrin
 Product Gene Name   

anti-NCSTN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 605254
 3D Structure    ModBase 3D Structure for Q92542
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 Clonality    Monoclonal
 Isotype    IgG2b,k
 Clone Number    AT3B2
 Host    Mouse
 Species Reactivity    Human, Mouse
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 Specificity    human Nicastrin (34-153aa)
 Purity/Purification    Protein G Purified
 Form/Format    PBS, pH 7.4, 0.1% sodium azide
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Recombinant human Nicastrin (34-153aa) purified from E Coli
 Immunogen Type    Recombinant protein
 Immunogen    NCSTN / Nicastrin antibody was raised against recombinant human Nicastrin (34-153aa) purified from E Coli
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-NCSTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NCSTN antibody

   This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly.
 Product Categories/Family for anti-NCSTN antibody    Family: Protease
 Applications Tested/Suitable for anti-NCSTN antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-NCSTN antibody    ELISA, IHC-P (5 ug/ml), WB (1:500 - 1:1000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-NCSTN antibody    Anti-NCSTN / Nicastrin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-NCSTN antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-NCSTN antibody    Anti-NCSTN / Nicastrin antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-NCSTN antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-NCSTN antibody    Anti-NCSTN / Nicastrin antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-NCSTN antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-NCSTN antibody    Western blot of mouse brain extracts.
anti-NCSTN antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NCSTN. It may not necessarily be applicable to this product.
 NCBI GI #    24638433
 NCBI GeneID    23385
 NCBI Accession #    NP_056146.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_015331.2 [Other Products]
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 UniProt Primary Accession #    Q92542 [Other Products]
 UniProt Secondary Accession #    Q5T207; Q5T208; Q86VV5 [Other Products]
 UniProt Related Accession #    Q92542 [Other Products]
 Molecular Weight    76,744 Da
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 NCBI Official Full Name    nicastrin isoform 1
 NCBI Official Synonym Full Names    nicastrin
 NCBI Official Symbol    NCSTN [Similar Products]
 NCBI Official Synonym Symbols   
ATAG1874
[Similar Products]
 NCBI Protein Information    nicastrin; anterior pharynx-defective 2
 UniProt Protein Name    Nicastrin
 Protein Family    Nicastrin
 UniProt Gene Name    NCSTN [Similar Products]
 UniProt Synonym Gene Names    KIAA0253 [Similar Products]
 UniProt Entry Name    NICA_HUMAN
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 NCBI Summary for NCSTN    This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
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 UniProt Comments for NCSTN    nicastrin: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Binds to proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP). Constitutively expressed in neural cells. Widely expressed. Belongs to the nicastrin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: Golgi apparatus; focal adhesion; membrane; integral to plasma membrane; endoplasmic reticulum; lysosomal membrane; melanosome; integral to membrane; plasma membrane

Molecular Function: protein binding; endopeptidase activity

Biological Process: positive regulation of catalytic activity; axon guidance; Notch signaling pathway; extracellular matrix organization and biogenesis; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; myeloid cell homeostasis; membrane protein ectodomain proteolysis; Notch receptor processing; proteolysis; T cell proliferation; extracellular matrix disassembly; amyloid precursor protein catabolic process; epithelial cell proliferation; beta-amyloid metabolic process; ephrin receptor signaling pathway; protein processing

Disease: Acne Inversa, Familial, 1
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 Research Articles on NCSTN    1. OCIAD2 also increased the interaction of nicastrin with C99 and stimulated APP processing via gamma-secretase activation, but did not affect Notch processing
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Mouse Monoclonal [clone AT3B2] (IgG2b,k) to Human NCSTN / Nicastrin
 Catalog #  Product Name  Catalog #  Product Name
 MBS241296  Rabbit Polyclonal to Human NCSTN / Nicastrin  MBS245353  Mouse Monoclonal [clone AT3B2] (IgG2b,k) to Human NCSTN / Nicastrin
 MBS240394  Rabbit Polyclonal to Human NCSTN / Nicastrin
Products associated with anti-NCSTN antibodyPathways associated with anti-NCSTN antibody
 Reference Product  PubMed Publications
 PSEN1 antibody  >14 publications with NCSTN and PSEN1
 PSENEN antibody  >7 publications with NCSTN and PSENEN
 PSEN2 antibody  >6 publications with NCSTN and PSEN2
 BACE1 antibody  >5 publications with NCSTN and BACE1
 APH1B antibody  >2 publications with NCSTN and APH1B
 NOTCH1 antibody  >1 publications with NCSTN and NOTCH1
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
Diseases associated with anti-NCSTN antibodyOrgans/Tissues associated with anti-NCSTN antibody
 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >19 publications with NCSTN and Neurodegenerative Diseases
 Alzheimer Disease Antibodies  >19 publications with NCSTN and Alzheimer Disease
 Hidradenitis suppurativa, familial Antibodies  >3 publications with NCSTN and Hidradenitis suppurativa, familial
 Nerve Degeneration Antibodies  >1 publications with NCSTN and Nerve Degeneration
 Liver Neoplasms, Experimental Antibodies  >1 publications with NCSTN and Liver Neoplasms, Experimental
 Carcinoma Antibodies  >1 publications with NCSTN and Carcinoma
 Neoplasms, Experimental Antibodies  >1 publications with NCSTN and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with NCSTN and Liver Neoplasms
 Cognition Disorders Antibodies  >1 publications with NCSTN and Cognition Disorders
 Inflammation Antibodies  >1 publications with NCSTN and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with NCSTN and Brain
 Skin Antibodies  >4 publications with NCSTN and Skin
 Blood Antibodies  >3 publications with NCSTN and Blood
 Pharynx Antibodies  >2 publications with NCSTN and Pharynx
 Liver Antibodies  >2 publications with NCSTN and Liver
 Nerve Antibodies  >1 publications with NCSTN and Nerve
 Vascular Antibodies  >1 publications with NCSTN and Vascular
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