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anti-TLX2 antibody :: Mouse NCX Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS603468 anti-TLX2 antibody
Unit / Price
0.1 mL  /  $665 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NCX (TLX2), Monoclonal Antibody

 Also Known As   

NCX (Sodium Calcium Exchanger)

 Product Synonym Names    Anti -NCX (Sodium Calcium Exchanger)
 Product Gene Name   

anti-TLX2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    chromosome: 2; Location: 2p13.1
 OMIM    604240
 3D Structure    ModBase 3D Structure for O43763
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 Clonality    Monoclonal
 Isotype    IgM
 Clone Number    6D601
 Host    Mouse
 Species Reactivity    Canine, Guinea Pig, Human, Mouse, Rabbit, Rat
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 Specificity    Recognizes canine Na+/ Ca2+ exchanger. Species Crossreactivity: human, mouse, rat, rabbit and guinea pig.
 Purity/Purification    Ascites
Ascites
 Form/Format    Supplied as a liquid in PBS, 0.05% sodium azide, 40% glycerol.
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 Immunogen    Purified canine cardiac Na+/ Ca2+ exchanger. Epitope: On the intracellular side of the plasma membrane (aa371-525).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-TLX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TLX2 antibody

   The Na+/Ca2+ exchanger of cardiac sarcolemma rapidly transports Ca2+ during excitation-concentration coupling and is the dominant myocardial Ca2+ efflux mechanism.
 Product Categories/Family for anti-TLX2 antibody    Antibodies; Abs to Ion Channel
 Applications Tested/Suitable for anti-TLX2 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

 Application Notes for anti-TLX2 antibody    Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry.
Dilution: Western Blot: 1:500; Detects a band of ~120kD (mature exchanger), as well as bands of ~70kD (proteolytic fragment) and ~160kD (non-reduced exchanger). Not recommended for rat tissue.
Immunocytochemistry: 1:100
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NCBI/Uniprot data below describe general gene information for TLX2. It may not necessarily be applicable to this product.
 NCBI GI #    5748490
 NCBI GeneID    3196
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 UniProt Primary Accession #    O43763 [Other Products]
 UniProt Secondary Accession #    Q9UD56; Q9UQ48 [Other Products]
 UniProt Related Accession #    O43763 [Other Products]
 Molecular Weight    30,251 Da [Similar Products]
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 NCBI Official Full Name    NCX
 NCBI Official Synonym Full Names    T-cell leukemia homeobox 2
 NCBI Official Symbol    TLX2 [Similar Products]
 NCBI Official Synonym Symbols   
NCX; HOX11L1; TLX2
[Similar Products]
 NCBI Protein Information    T-cell leukemia homeobox protein 2; homeo box 11-like 1; homeobox protein Hox-11L1; neural crest homeobox protein
 UniProt Protein Name    T-cell leukemia homeobox protein 2
 UniProt Synonym Protein Names   
Homeobox protein Hox-11L1; Neural crest homeobox protein
 Protein Family    T-cell leukemia homeobox protein
 UniProt Gene Name    TLX2 [Similar Products]
 UniProt Synonym Gene Names    HOX11L1; NCX [Similar Products]
 UniProt Entry Name    TLX2_HUMAN
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 NCBI Summary for TLX2    This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq]
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 UniProt Comments for TLX2    TLX2: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract.

Protein type: Transcription factor; DNA-binding; Cell development/differentiation

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: cytoplasm; nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; mesoderm formation; negative regulation of dendrite morphogenesis; enteric nervous system development
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 Research Articles on TLX2    1. This paper describes sequencing and comparison of 5' flanking regions of the gene, and expression in several neuroblastoma cell lines, in both mouse and human.
2. TLX2 is an orphan homeodomain transcription factor whose expression is mainly associated with tissues derived from neural crest cells.
3. These results support the PHOX2B-TLX2 promoter interaction, suggesting a physiological role in the transcription-factor cascade underlying the differentiation of neuronal lineages of the Autonomic Nervous System during human embryogenesis.
4. Alignment of sequences obtained from rat, human, and mouse indicates that putative regulatory elements of the Hox11L1 gene are conserved in rat, mice, and humans.
5. Hox11L1 has a role in tumorigenesis in gastrointestinal stromal tumors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TLX2 antibodyDiseases associated with anti-TLX2 antibody
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 ALK2 Signaling Events Pathway antibodies  ALK2 Signaling Events Pathway Diagram
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >7 publications with TLX2 and Disease Models, Animal
 Arrhythmias, Cardiac Antibodies  >3 publications with TLX2 and Arrhythmias, Cardiac
 Hypertension Antibodies  >2 publications with TLX2 and Hypertension
 Aneuploidy Antibodies  >1 publications with TLX2 and Aneuploidy
 Tachycardia, Ventricular Antibodies  >1 publications with TLX2 and Tachycardia, Ventricular
 Abnormalities, Drug-Induced Antibodies  >1 publications with TLX2 and Abnormalities, Drug-Induced
 Lung Diseases Antibodies  >1 publications with TLX2 and Lung Diseases
 Hypertrophy Antibodies  >1 publications with TLX2 and Hypertrophy
 Chromosome Aberrations Antibodies  >1 publications with TLX2 and Chromosome Aberrations
 Myocardial Infarction Antibodies  >1 publications with TLX2 and Myocardial Infarction
Organs/Tissues associated with anti-TLX2 antibody
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >1 publications with TLX2 and Lymph Node
 Testis Antibodies  >1 publications with TLX2 and Testis
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