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anti-NFATc1 antibody :: Mouse anti-Human NFATc1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200132
Western Blot (WB)
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NFATc1, Monoclonal Antibody

★Popular Item★
 Also Known As   

NFATc1 antibody (clone AT1C3)

 Product Synonym Names    nuclear factor of activated T-cells; cytosolic component 1 isoform A; NF-ATC; NFATc; NFAT2
 Product Gene Name   

anti-NFATc1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG2a, k
 Clone Number    AT1C3
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Clone    Anti-human NFATc1 mAb, clone AT1C3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NFATc1 protein.
 Immunogen    Recombinant human NFATc1 (428-716aa) purified from E Coli
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 Preparation and Storage    Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-NFATc1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NFATc1 antibody

   Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1(NFATc1) is a component of the nuclear factor of activated T cells DNA-binding transcription complex which consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. This protein plays a main role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription and functions as a major molecular target for the immunosuppressive drugs such as cyclosporine A. NFATc1 is expressed in most human primary lymphocytes and mature human T- and B-cell neoplasms.
 Product Categories/Family for anti-NFATc1 antibody    Transcription & Translation
 Applications Tested/Suitable for anti-NFATc1 antibody   

ELISA (EIA), Western Blot (WB) (Cell lysate)

 Application Notes for anti-NFATc1 antibody    The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.
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 Western Blot (WB) of anti-NFATc1 antibody    Cell lysates of Ramos (20ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human NFATc1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
anti-NFATc1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NFATc1. It may not necessarily be applicable to this product.
 NCBI GI #    27502393
 NCBI GeneID    4772
 NCBI Accession #    NP_765978 [Other Products]
 NCBI GenBank Nucleotide #    NM_172390.2 [Other Products]
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 UniProt Secondary Accession #    Q12865; Q15793; Q2M1S3; B5B2M4; B5B2M5; B5B2M6; B5B2M7; B5B2M8; B5B2M9; B5B2N1 [Other Products]
 UniProt Related Accession #    O95644 [Other Products]
 Molecular Weight    38,626 Da
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 NCBI Official Full Name    nuclear factor of activated T-cells, cytoplasmic 1 isoform A
 NCBI Official Synonym Full Names    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
 NCBI Official Symbol    NFATC1 [Similar Products]
 NCBI Official Synonym Symbols   
NFAT2; NFATc; NF-ATC
[Similar Products]
 NCBI Protein Information    nuclear factor of activated T-cells, cytoplasmic 1; NFAT transcription complex cytosolic component
 UniProt Protein Name    Nuclear factor of activated T-cells, cytoplasmic 1
 UniProt Synonym Protein Names   
NFAT transcription complex cytosolic component; NF-ATc; NFATc
 Protein Family    Nuclear factor of activated T-cells
 UniProt Gene Name    NFATC1 [Similar Products]
 UniProt Synonym Gene Names    NFAT2; NFATC; NF-ATc1; NFATc1; NF-ATc; NFATc [Similar Products]
 UniProt Entry Name    NFAC1_HUMAN
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 NCBI Summary for NFATc1    The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
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 UniProt Comments for NFATc1    NFAT2: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Six splice variant isoforms have been identified. Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 18q23

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nuclear chromatin; cytosol; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; FK506 binding; mitogen-activated protein kinase p38 binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; heart development; positive regulation of transcription, DNA-dependent; calcium ion transport; epithelial to mesenchymal transition; innate immune response; positive regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; G1/S transition of mitotic cell cycle
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Product References and Citations for anti-NFATc1 antibody

   Akimzhanov A, et al., (2008) Am J Pathol 172(1):215-224 Asagiri M, et al., (2005) J Exp Med 202(9):1261-1269 Rao A, et al., (1997) Annu Rev Immunol 15:707-747
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 Research Articles on NFATc1    1. VEGF regulates NFATc1 binding to angiogenesis-related genes in the endothelium
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFATc1 antibodyPathways associated with anti-NFATc1 antibody
 Reference Product  PubMed Publications
 FOS antibody  >217 publications with NFATc1 and FOS
 JUN antibody  >158 publications with NFATc1 and JUN
 IL2 antibody  >4 publications with NFATc1 and IL2
 EGR2 antibody  >3 publications with NFATc1 and EGR2
 KPNB1 antibody  >2 publications with NFATc1 and KPNB1
 PPP3CA antibody  >2 publications with NFATc1 and PPP3CA
 MAPK14 antibody  >2 publications with NFATc1 and MAPK14
 PPP3R1 antibody  >2 publications with NFATc1 and PPP3R1
 IL4 antibody  >1 publications with NFATc1 and IL4
 EGR1 antibody  >1 publications with NFATc1 and EGR1
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Ca2+ Pathway antibodies  Ca2+ Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 FCERI Mediated Ca+2 Mobilization Pathway antibodies  FCERI Mediated Ca+2 Mobilization Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
Diseases associated with anti-NFATc1 antibodyOrgans/Tissues associated with anti-NFATc1 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >98 publications with NFATc1 and Necrosis
 Inflammation Antibodies  >92 publications with NFATc1 and Inflammation
 Disease Models, Animal Antibodies  >50 publications with NFATc1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >47 publications with NFATc1 and Cardiovascular Diseases
 Hypertrophy Antibodies  >26 publications with NFATc1 and Hypertrophy
 Heart Defects, Congenital Antibodies  >12 publications with NFATc1 and Heart Defects, Congenital
 Kidney Diseases Antibodies  >9 publications with NFATc1 and Kidney Diseases
 Cardiomegaly Antibodies  >7 publications with NFATc1 and Cardiomegaly
 Liver Diseases Antibodies  >6 publications with NFATc1 and Liver Diseases
 Atrophy Antibodies  >6 publications with NFATc1 and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >591 publications with NFATc1 and Bone
 Blood Antibodies  >238 publications with NFATc1 and Blood
 Heart Antibodies  >78 publications with NFATc1 and Heart
 Vascular Antibodies  >65 publications with NFATc1 and Vascular
 Connective Tissue Antibodies  >61 publications with NFATc1 and Connective Tissue
 Brain Antibodies  >33 publications with NFATc1 and Brain
 Embryonic Tissue Antibodies  >31 publications with NFATc1 and Embryonic Tissue
 Kidney Antibodies  >27 publications with NFATc1 and Kidney
 Spleen Antibodies  >20 publications with NFATc1 and Spleen
 Lung Antibodies  >18 publications with NFATc1 and Lung
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