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anti-NFE2L2 antibody :: Mouse anti-Human NFE2L2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120303
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NFE2L2, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human NFE2L2

 Product Synonym Names    Homo sapiens nuclear factor (erythroid-derived 2)-like 2 ; NRF2
 Product Gene Name   

anti-NFE2L2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600492
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    437C2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-NFE2L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NFE2L2 antibody

   NFE2 (MIM 601490), NFE2L1 (MIM 163260), and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN (MIM 165160) and FOS (MIM 164810), although remaining regions have diverged considerably from each other (Chan et al., 1995).[supplied by OMIM] [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-NFE2L2 antibody   

Dot Blot (DB), Immunocytochemistry (ICC)

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 Quality Control of anti-NFE2L2 antibody    Western blot analysis of immunized recombinant protein, using anti-NFE2L2 monoclonal antibody.
anti-NFE2L2 antibody Quality Control image
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 Quality Control #2 of anti-NFE2L2 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-NFE2L2 antibody Quality Control #2 image
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 Immunocytochemistry (ICC) of anti-NFE2L2 antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-NFE2L2 mAb. [Lot No. 437C2a-1]
anti-NFE2L2 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for NFE2L2. It may not necessarily be applicable to this product.
 NCBI GI #    372620346
 NCBI GeneID    4780
 NCBI Accession #    NP_006155.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006164 [Other Products]
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 UniProt Secondary Accession #    Q53RW6; Q59HH2; Q96F71; B2RBU2; B4E338; E9PGJ7 [Other Products]
 UniProt Related Accession #    Q16236 [Other Products]
 Molecular Weight    65,356 Da
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 NCBI Official Full Name    Homo sapiens nuclear factor, erythroid 2-like 2 (NFE2L2), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    nuclear factor, erythroid 2-like 2
 NCBI Official Symbol    NFE2L2 [Similar Products]
 NCBI Official Synonym Symbols   
NRF2
[Similar Products]
 NCBI Protein Information    nuclear factor erythroid 2-related factor 2; HEBP1; NF-E2-related factor 2; NFE2-related factor 2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid derived 2, like 2
 UniProt Protein Name    Nuclear factor erythroid 2-related factor 2
 UniProt Synonym Protein Names   
HEBP1; Nuclear factor, erythroid derived 2, like 2
 Protein Family    Nuclear factor erythroid 2-related factor
 UniProt Gene Name    NFE2L2 [Similar Products]
 UniProt Entry Name    NF2L2_HUMAN
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 NCBI Summary for NFE2L2    This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for NFE2L2    NRF2: a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: nucleoplasm; centrosome; cytoplasm; plasma membrane; nucleus; cytosol; chromatin

Molecular Function: protein domain specific binding; protein binding; DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; positive regulation of blood coagulation; unfolded protein response; regulation of embryonic development; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter
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 Research Articles on NFE2L2    1. The reduction of Nrf2mRNA at the transcriptional level is responsible for the reversal of multi-drug resistance by wogonin in leukemia cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFE2L2 antibodyPathways associated with anti-NFE2L2 antibody
 Reference Product  PubMed Publications
 HMOX1 antibody  >1048 publications with NFE2L2 and HMOX1
 KEAP1 antibody  >735 publications with NFE2L2 and KEAP1
 NQO1 antibody  >499 publications with NFE2L2 and NQO1
 JUN antibody  >414 publications with NFE2L2 and JUN
 CUL3 antibody  >66 publications with NFE2L2 and CUL3
 MAFG antibody  >24 publications with NFE2L2 and MAFG
 PMF1 antibody  >7 publications with NFE2L2 and PMF1
 CREBBP antibody  >6 publications with NFE2L2 and CREBBP
 UBC antibody  >3 publications with NFE2L2 and UBC
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Keap1-Nrf2 Pathway antibodies  Keap1-Nrf2 Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
Diseases associated with anti-NFE2L2 antibodyOrgans/Tissues associated with anti-NFE2L2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >590 publications with NFE2L2 and Inflammation
 Nervous System Diseases Antibodies  >333 publications with NFE2L2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >290 publications with NFE2L2 and Cardiovascular Diseases
 Necrosis Antibodies  >266 publications with NFE2L2 and Necrosis
 Liver Diseases Antibodies  >259 publications with NFE2L2 and Liver Diseases
 Kidney Diseases Antibodies  >112 publications with NFE2L2 and Kidney Diseases
 Drug-Induced Liver Injury Antibodies  >111 publications with NFE2L2 and Drug-Induced Liver Injury
 Liver Neoplasms Antibodies  >107 publications with NFE2L2 and Liver Neoplasms
 Fibrosis Antibodies  >105 publications with NFE2L2 and Fibrosis
 Gastrointestinal Diseases Antibodies  >102 publications with NFE2L2 and Gastrointestinal Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >580 publications with NFE2L2 and Liver
 Blood Antibodies  >468 publications with NFE2L2 and Blood
 Lung Antibodies  >400 publications with NFE2L2 and Lung
 Brain Antibodies  >347 publications with NFE2L2 and Brain
 Vascular Antibodies  >270 publications with NFE2L2 and Vascular
 Muscle Antibodies  >214 publications with NFE2L2 and Muscle
 Kidney Antibodies  >195 publications with NFE2L2 and Kidney
 Heart Antibodies  >193 publications with NFE2L2 and Heart
 Skin Antibodies  >113 publications with NFE2L2 and Skin
 Nerve Antibodies  >83 publications with NFE2L2 and Nerve
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