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anti-NFYB antibody :: Mouse anti-Human NFYB Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120069
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NFYB, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human NFYB

 Product Synonym Names    nuclear transcription factor Y, beta (NFYB); HAP3; CBF-A; CBF-B; NF-YB
 Product Gene Name   

anti-NFYB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    189904
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    NFYBA7
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-NFYB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NFYB antibody

   The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-NFYB antibody   

Dot Blot (DB), Immunocytochemistry (ICC)

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 Quality Control of anti-NFYB antibody    Left: Western blot analysis of immunized recombinant protein, using anti-NFYB monoclonal antibody.
anti-NFYB antibody Quality Control image
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 Immunocytochemistry (ICC) of anti-NFYB antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-NFYB mAb. [Lot No.NFYBA7-2]
anti-NFYB antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for NFYB. It may not necessarily be applicable to this product.
 NCBI GI #    45597173
 NCBI GeneID    4801
 NCBI Accession #    NP_006157.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006166 [Other Products]
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 UniProt Secondary Accession #    Q96IY8; A8K7B9 [Other Products]
 UniProt Related Accession #    P25208 [Other Products]
 Molecular Weight    22,831 Da
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 NCBI Official Full Name    Homo sapiens nuclear transcription factor Y, beta (NFYB), mRNA
 NCBI Official Synonym Full Names    nuclear transcription factor Y, beta
 NCBI Official Symbol    NFYB [Similar Products]
 NCBI Official Synonym Symbols   
HAP3; CBF-A; CBF-B; NF-YB
[Similar Products]
 NCBI Protein Information    nuclear transcription factor Y subunit beta; CAAT box DNA-binding protein subunit B; CCAAT-binding transcription factor subunit A; Transcription factor NF-Y, B subunit; nuclear transcription factor Y subunit B
 UniProt Protein Name    Nuclear transcription factor Y subunit beta
 UniProt Synonym Protein Names   
CAAT box DNA-binding protein subunit B; Nuclear transcription factor Y subunit B; NF-YB
 Protein Family    Nuclear transcription factor
 UniProt Gene Name    NFYB [Similar Products]
 UniProt Entry Name    NFYB_HUMAN
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 NCBI Summary for NFYB    The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NFYB    NFYB: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. Belongs to the NFYB/HAP3 subunit family.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 12q22-q23

Cellular Component: nucleoplasm; CCAAT-binding factor complex; nucleus

Molecular Function: protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; protein complex binding; transcription factor activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; cellular lipid metabolic process
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 Research Articles on NFYB    1. The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFYB antibodyPathways associated with anti-NFYB antibody
 Reference Product  PubMed Publications
 NFYA antibody  >16 publications with NFYB and NFYA
 NFYC antibody  >10 publications with NFYB and NFYC
 SP1 antibody  >7 publications with NFYB and SP1
 EP300 antibody  >1 publications with NFYB and EP300
 MYC antibody  >1 publications with NFYB and MYC
 CIITA antibody  >1 publications with NFYB and CIITA
 Products by Pathway  Pathway Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 ATF6-alpha Activates Chaperone Genes Pathway antibodies  ATF6-alpha Activates Chaperone Genes Pathway Diagram
 ATF6-alpha Activates Chaperones Pathway antibodies  ATF6-alpha Activates Chaperones Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with anti-NFYB antibodyOrgans/Tissues associated with anti-NFYB antibody
 Disease Name  Pubmed Publications
 Seizures Antibodies  >1 publications with NFYB and Seizures
 Nervous System Diseases Antibodies  >1 publications with NFYB and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with NFYB and Brain Diseases
 Inflammation Antibodies  >1 publications with NFYB and Inflammation
 Necrosis Antibodies  >1 publications with NFYB and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with NFYB and Brain
 Muscle Antibodies  >3 publications with NFYB and Muscle
 Nerve Antibodies  >3 publications with NFYB and Nerve
 Embryonic Tissue Antibodies  >2 publications with NFYB and Embryonic Tissue
 Stomach Antibodies  >2 publications with NFYB and Stomach
 Pharynx Antibodies  >1 publications with NFYB and Pharynx
 Vascular Antibodies  >1 publications with NFYB and Vascular
 Heart Antibodies  >1 publications with NFYB and Heart
 Kidney Antibodies  >1 publications with NFYB and Kidney
 Intestine Antibodies  >1 publications with NFYB and Intestine
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