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anti-NGFR antibody :: Mouse anti-Human NGFR Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS370134
Unit / Price
5 + Control Slides  /  $115 +1 FREE 8GB USB
3 ml (Prediluted)  /  $165 +1 FREE 8GB USB
0.1 mL (Concentrate)  /  $185 +1 FREE 8GB USB
7 ml (Prediluted)  /  $240 +1 FREE 8GB USB
15 ml (Prediluted)  /  $385 +1 FREE 8GB USB
0.5 mL (Concentrate)  /  $425 +1 FREE 8GB USB
1 mL (Concentrate)  /  $700 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NGFR, Monoclonal Antibody

 Also Known As   

NGFR

 Product Gene Name   

anti-NGFR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (47572655..47592382). Location: 17q21-q22
 OMIM    162010
 3D Structure    ModBase 3D Structure for P08138
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    NGFR/c10
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    NGFR is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
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 Control    Breast, CNS Tumors
 Localization    Cytoplasmic
 Reactivity Note    Paraffin, Frozen
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 Preparation and Storage    Store at 2 to 8 degree C in the dark.
 Other Notes    Small volumes of anti-NGFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NGFR antibody

   NGFR (Nerve Growth Factor Receptor), also termed p75 or CD271, is the low-affinity NGFR (LNGFR) which binds NGF and other neurotrophins, including BDNF, NT3 and NT4/5 with similar low-affinity. NGFR p75 is a 75 kD transmembrane glycoprotein that is mainly expressed in Schwann cells and neurons and in a variety of non-neuronal cells. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE-like proteases and the JNK pathway. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells). NGFR is expressed not only in sympathetic and sensory neurons, but also in various neural crest cell or tumor derivatives such as melanocytes, Melanomas, Neuroblastomas, Pheochromocytomas, Neurofibromas, and neurotized nevi (Type C melanocytes). It is now apparent that expression of NGFR is ubiquitous and not limited to the nervous system. Studies in Prostate and Urothelial Cancer suggest that NGFR may act as a tumor suppressor, negatively regulating cell growth and proliferation. NGFR labels the myoepithelial cells of breast ducts and intralobular fibroblasts of breast ducts and, thus, aids in the diagnosis of malignancy in the breast.
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 Dilution Information of anti-NGFR antibody    anti-NGFR antibody Dilution Information image
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 Immunohistochemistry (IHC) of anti-NGFR antibody    anti-NGFR antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NGFR. It may not necessarily be applicable to this product.
 NCBI GI #    119615083
 NCBI GeneID    4804
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 UniProt Primary Accession #    P08138 [Other Products]
 UniProt Secondary Accession #    B2R961 [Other Products]
 UniProt Related Accession #    P08138 [Other Products]
 Molecular Weight    45,183 Da
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 NCBI Official Full Name    nerve growth factor receptor (TNFR superfamily, member 16)
 NCBI Official Synonym Full Names    nerve growth factor receptor
 NCBI Official Symbol    NGFR [Similar Products]
 NCBI Official Synonym Symbols   
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 16; p75 ICD; NGF receptor; OTTHUMP00000220318; OTTHUMP00000220319; TNFR superfamily, member 16; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 16
 UniProt Synonym Protein Names   
Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    NGFR [Similar Products]
 UniProt Synonym Gene Names    TNFRSF16 [Similar Products]
 UniProt Entry Name    TNR16_HUMAN
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 NCBI Summary for NGFR    Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq]
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 UniProt Comments for NGFR    Function: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Ref.11

Subunit structure: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1

By similarity. Interacts with LINGO1. Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11

Subcellular location: Membrane; Single-pass type I membrane protein.

Domain: Death domain is responsible for interaction with RANBP9.The extracellular domain is responsible for interaction with NTRK1

Post-translational modification: N- and O-glycosylated. Ref.12O-linked glycans consist of Gal1-3GalNAc core elongated by 1 or 2 NeuNAc.Phosphorylated on serine residues.

Sequence similarities: Contains 1 death domain.Contains 4 TNFR-Cys repeats.
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 Research Articles on NGFR    1. Observation that a relatively high frequency of CD271/Sox10-positive cells correlates with higher metastatic potential and worse prognosis further supports that CD271-positive cells within human melanoma represent genuine cancer stem cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NGFR antibodyPathways associated with anti-NGFR antibody
 Reference Product  PubMed Publications
 NGF antibody  >220 publications with NGFR and NGF
 NTRK1 antibody  >90 publications with NGFR and NTRK1
 NTRK2 antibody  >28 publications with NGFR and NTRK2
 NTRK3 antibody  >16 publications with NGFR and NTRK3
 MAG antibody  >3 publications with NGFR and MAG
 NTF4 antibody  >3 publications with NGFR and NTF4
 MAPK1 antibody  >2 publications with NGFR and MAPK1
 GRB2 antibody  >2 publications with NGFR and GRB2
 RTN4R antibody  >2 publications with NGFR and RTN4R
 SHC1 antibody  >2 publications with NGFR and SHC1
 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Axonal Growth Stimulation Pathway antibodies  Axonal Growth Stimulation Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Ceramide Signalling Pathway antibodies  Ceramide Signalling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 NADE Modulates Death Signalling Pathway antibodies  NADE Modulates Death Signalling Pathway Diagram
 NF-kB Is Activated And Signals Survival Pathway antibodies  NF-kB Is Activated And Signals Survival Pathway Diagram
 NFG And ProNGF Binds To P75NTR Pathway antibodies  NFG And ProNGF Binds To P75NTR Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
Diseases associated with anti-NGFR antibodyOrgans/Tissues associated with anti-NGFR antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >141 publications with NGFR and Neoplasms
 Central Nervous System Diseases Antibodies  >57 publications with NGFR and Central Nervous System Diseases
 Death Antibodies  >51 publications with NGFR and Death
 Neurodegenerative Diseases Antibodies  >33 publications with NGFR and Neurodegenerative Diseases
 Carcinoma Antibodies  >31 publications with NGFR and Carcinoma
 Nerve Degeneration Antibodies  >29 publications with NGFR and Nerve Degeneration
 Inflammation Antibodies  >20 publications with NGFR and Inflammation
 Brain Neoplasms Antibodies  >18 publications with NGFR and Brain Neoplasms
 Mental Disorders Antibodies  >18 publications with NGFR and Mental Disorders
 Neoplasm Metastasis Antibodies  >14 publications with NGFR and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >154 publications with NGFR and Brain
 Mixed Antibodies  >8 publications with NGFR and Mixed
 Spleen Antibodies  >3 publications with NGFR and Spleen
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