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anti-NKG2D antibody :: Rat anti-Mouse NKG2D Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690789 anti-NKG2D antibody
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NKG2D, Monoclonal Antibody

 Also Known As   

Rat Anti-Mouse NKG2D

 Product Synonym Names    Klrk1; Nkg2d; NKG2-D; D6H12S2489E
 Product Gene Name   

anti-NKG2D antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000072.6 (129610323..129623864, complement). Location: 6 F3; 6 63.44 cM
 3D Structure    ModBase 3D Structure for O54709
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    (4J50)
 Host    Rat
 Species Reactivity    Mouse
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 Form/Format    Lyophilized
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of NKG2D.
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-NKG2D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NKG2D antibody

   NKG2D is a type II transmembrane protein with an extracellular C-type lectin domain. It occurs as a disulfide-linked homodimer that associates with either the DAP12 or DAP10 transmembrane adapter proteins. NKG2D is expressed on NK cells and some T cell subsets, where it functions as an activating receptor to trigger cytolytic activity and cytokine secretion. Ligands for human NKG2D include MICA, MICB, and ULBP-1, -2, -3, and -4. Mouse NKG2D ligands include H60, MULT-1, and Rae-1 alpha, beta, gamma, delta, and epsilon.
 Applications Tested/Suitable for anti-NKG2D antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for NKG2D. It may not necessarily be applicable to this product.
 NCBI GI #    134023658
 NCBI GeneID    27007
 NCBI Accession #    NP_001076791.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001083322.2 [Other Products]
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 UniProt Primary Accession #    O54709 [Other Products]
 UniProt Related Accession #    O54709 [Other Products]
 Molecular Weight    26,710 Da
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 NCBI Official Full Name    NKG2-D type II integral membrane protein isoform b
 NCBI Official Synonym Full Names    killer cell lectin-like receptor subfamily K, member 1
 NCBI Official Symbol    Klrk1 [Similar Products]
 NCBI Official Synonym Symbols   
Nkg2d; NKG2-D; D6H12S2489E
[Similar Products]
 NCBI Protein Information    NKG2-D type II integral membrane protein; NK cell receptor D; natural killer cell group 2D; NKG2-D-activating NK receptor
 UniProt Protein Name    NKG2-D type II integral membrane protein
 UniProt Synonym Protein Names   
Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor
 Protein Family    NKG2D ligand
 UniProt Gene Name    Klrk1 [Similar Products]
 UniProt Synonym Gene Names    Nkg2d [Similar Products]
 UniProt Entry Name    NKG2D_MOUSE
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 UniProt Comments for NKG2D    Function: Receptor for RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. Involved in the immune surveillance exerted by T and B lymphocytes. Ref.5

Subunit structure: Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression.

Subcellular location: Membrane; Single-pass type II membrane protein

By similarity.

Tissue specificity: Natural killer cells. Expressed on DC cells. Ref.7

Miscellaneous: Structurally distinct families of ligands for mouse and human NKG2D receptors have been characterized. They might be orthologs.

Sequence similarities: Contains 1 C-type lectin domain.
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 Research Articles on NKG2D    1. The severity of experimental autoimmune encephalitis was decreased in NKG2D-deficient mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Rat Anti-Mouse NKG2D
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 MBS9369362  Goat NKG2D Ligand 1 (ULBP1) ELISA Kit  MBS426409  NKG2D / KLRK1 Immunizing Peptide
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 MBS9367901  Chicken NKG2D Ligand 1 (ULBP1) ELISA Kit  MBS9363027  Mouse NKG2D Ligand 1 (ULBP1) ELISA Kit
 MBS9346089  Cavy NKG2D Ligand 1 (ULBP1) ELISA Kit  MBS834175  NKG2D antibody (PE)
Pathways associated with anti-NKG2D antibodyDiseases associated with anti-NKG2D antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >307 publications with NKG2D and Neoplasms
 Carcinoma Antibodies  >61 publications with NKG2D and Carcinoma
 Liver Diseases Antibodies  >44 publications with NKG2D and Liver Diseases
 Necrosis Antibodies  >43 publications with NKG2D and Necrosis
 Neoplasms, Experimental Antibodies  >40 publications with NKG2D and Neoplasms, Experimental
 Inflammation Antibodies  >39 publications with NKG2D and Inflammation
 Melanoma Antibodies  >33 publications with NKG2D and Melanoma
 Adenocarcinoma Antibodies  >28 publications with NKG2D and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >26 publications with NKG2D and Cardiovascular Diseases
 Ovarian Neoplasms Antibodies  >19 publications with NKG2D and Ovarian Neoplasms
Organs/Tissues associated with anti-NKG2D antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >28 publications with NKG2D and Skin
 Spleen Antibodies  >20 publications with NKG2D and Spleen
 Thymus Antibodies  >3 publications with NKG2D and Thymus
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