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anti-NMNAT1 antibody :: Mouse anti-Human NMNAT1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120521
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NMNAT1, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human NMNAT1

 Product Synonym Names    Homo sapiens nicotinamide nucleotide adenylyltransferase 1 (NMNAT1), mRNA; NMNAT;PNAT1;PNAT-1
 Product Gene Name   

anti-NMNAT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608553
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2642C5a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-NMNAT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NMNAT1 antibody

   The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD (Zhang et al., 2003 [PubMed 12574164]).[supplied by OMIM][NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-NMNAT1 antibody   

Dot Blot (DB), Immunocytochemistry (ICC)

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 Quality Control of anti-NMNAT1 antibody    Left: Western blot analysis of immunized recombinant protein, using anti-NMNAT1 monoclonal antibody. Right: CBB staining of immunized recombinant protein.
anti-NMNAT1 antibody Quality Control image
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 Quality Control #2 of anti-NMNAT1 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-NMNAT1 antibody Quality Control #2 image
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NCBI/Uniprot data below describe general gene information for NMNAT1. It may not necessarily be applicable to this product.
 NCBI GI #    95113669
 NCBI GeneID    64802
 NCBI Accession #    NP_073624.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_022787 [Other Products]
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 UniProt Secondary Accession #    Q8TAE9; Q9H247; Q9H6B6; B1AN63 [Other Products]
 UniProt Related Accession #    Q9HAN9 [Other Products]
 Molecular Weight    31,932 Da
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 NCBI Official Full Name    Homo sapiens nicotinamide nucleotide adenylyltransferase 1 (NMNAT1), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    nicotinamide nucleotide adenylyltransferase 1
 NCBI Official Symbol    NMNAT1 [Similar Products]
 NCBI Official Synonym Symbols   
LCA9; NMNAT; PNAT1
[Similar Products]
 NCBI Protein Information    nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NMN/NaMN adenylyltransferase 1; nicotinamide mononucleotide adenylyltransferase 1; nicotinamide-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 1; pyridine nucleotide adenylyltransferase 1
 UniProt Protein Name    Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
 UniProt Synonym Protein Names   
Nicotinamide-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1
 UniProt Gene Name    NMNAT1 [Similar Products]
 UniProt Entry Name    NMNA1_HUMAN
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 NCBI Summary for NMNAT1    This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014]
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 UniProt Comments for NMNAT1    NMNAT1: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults. Belongs to the eukaryotic NMN adenylyltransferase family.

Protein type: EC 2.7.7.1; Transferase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.7.18

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; ATP binding

Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; water-soluble vitamin metabolic process

Disease: Leber Congenital Amaurosis 9
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 Research Articles on NMNAT1    1. theNMNAT1 p.Glu257Lys variant is a hypomorphic variant that almost without exception causes leber congenital amaurosis (LCA) in combination with more severe NMNAT1 variants.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NMNAT1 antibodyPathways associated with anti-NMNAT1 antibody
 Reference Product  PubMed Publications
 SIRT1 antibody  >4 publications with NMNAT1 and SIRT1
 Products by Pathway  Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
 Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies  Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram
 Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway antibodies  Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway Diagram
Diseases associated with anti-NMNAT1 antibodyOrgans/Tissues associated with anti-NMNAT1 antibody
 Disease Name  Pubmed Publications
 Nerve Degeneration Antibodies  >34 publications with NMNAT1 and Nerve Degeneration
 Leber Congenital Amaurosis Antibodies  >11 publications with NMNAT1 and Leber Congenital Amaurosis
 Retinal Degeneration Antibodies  >6 publications with NMNAT1 and Retinal Degeneration
 Atrophy Antibodies  >4 publications with NMNAT1 and Atrophy
 Necrosis Antibodies  >2 publications with NMNAT1 and Necrosis
 Optic Atrophy Antibodies  >2 publications with NMNAT1 and Optic Atrophy
 Cardiovascular Diseases Antibodies  >2 publications with NMNAT1 and Cardiovascular Diseases
 Macular Degeneration Antibodies  >2 publications with NMNAT1 and Macular Degeneration
 Fibrosis Antibodies  >1 publications with NMNAT1 and Fibrosis
 Lung Diseases Antibodies  >1 publications with NMNAT1 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with NMNAT1 and Brain
 Eye Antibodies  >9 publications with NMNAT1 and Eye
 Lung Antibodies  >3 publications with NMNAT1 and Lung
 Kidney Antibodies  >3 publications with NMNAT1 and Kidney
 Muscle Antibodies  >3 publications with NMNAT1 and Muscle
 Blood Antibodies  >2 publications with NMNAT1 and Blood
 Embryonic Tissue Antibodies  >2 publications with NMNAT1 and Embryonic Tissue
 Heart Antibodies  >1 publications with NMNAT1 and Heart
 Intestine Antibodies  >1 publications with NMNAT1 and Intestine
 Prostate Antibodies  >1 publications with NMNAT1 and Prostate
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