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anti-NP antibody :: Mouse NP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS856132
Testing Data
Unit / Price
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NP, Monoclonal Antibody

 Also Known As   

NP Antibody

 Product Gene Name   

anti-NP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613179
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 Clonality    Monoclonal
 Isotype    IgG2a
 Host    Mouse
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 Specificity    Anti-NP recognizes NP expression in HEK293 whole cell lysate.
 Form/Format    Each vial contains 100 ug IgG in 100 ul of citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.
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 Source Note    Purified mouse monoclonal antibody generated using E Coli expressed recombinant protein NP as immunogen.
 Immunogen    Recombinant protein corresponding to fragment (aa/68-289) NP.
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 Preparation and Storage    The antibody may be stored at -20 degree C for one year in its original formulation. Additionally, antibody may be stored at 2 degree C to 8 degree C for up to 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles of the diluted antibody.
 Other Notes    Small volumes of anti-NP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NP antibody    Plant antibody
 Applications Tested/Suitable for anti-NP antibody   

ELISA (EIA), Western Blot (WB-Re), Western Blot (WB-Ce)

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 Testing Data of anti-NP antibody    anti-NP antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for NP. It may not necessarily be applicable to this product.
 NCBI GI #    157168362
 NCBI GeneID    4860
 NCBI Accession #    NP_000261.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000270.2 [Other Products]
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 UniProt Secondary Accession #    Q15160; Q5PZ03; B2R8S5; D3DS00 [Other Products]
 UniProt Related Accession #    P00491 [Other Products]
 Molecular Weight    32,118 Da
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 NCBI Official Full Name    purine nucleoside phosphorylase
 NCBI Official Synonym Full Names    purine nucleoside phosphorylase
 NCBI Official Symbol    PNP [Similar Products]
 NCBI Official Synonym Symbols   
NP; PUNP; PRO1837
[Similar Products]
 NCBI Protein Information    purine nucleoside phosphorylase; HEL-S-156an; inosine phosphorylase; inosine-guanosine phosphorylase; epididymis secretory sperm binding protein Li 156an; purine-nucleoside:orthophosphate ribosyltransferase
 UniProt Protein Name    Purine nucleoside phosphorylase
 UniProt Synonym Protein Names   
Inosine phosphorylase; Inosine-guanosine phosphorylase
 Protein Family    Nucleoprotein
 UniProt Gene Name    PNP [Similar Products]
 UniProt Synonym Gene Names    NP; PNP [Similar Products]
 UniProt Entry Name    PNPH_HUMAN
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 NCBI Summary for NP    This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NP    NP: a metabolic enzyme with purine-nucleoside phosphorylase activity. Defects are the cause of nucleoside phosphorylase deficiency (NP deficiency), with severe T-cell immunodeficiency with neurologic disorder in children.

Protein type: Transferase; Nucleotide Metabolism - pyrimidine; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.2.1; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 14q13.1

Cellular Component: cytoskeleton; cytoplasm; intracellular; cytosol

Molecular Function: purine binding; nucleoside binding; drug binding; phosphate binding; purine-nucleoside phosphorylase activity

Biological Process: response to drug; inosine catabolic process; nicotinamide riboside catabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine nucleotide catabolic process; immune response; positive regulation of T cell proliferation; positive regulation of alpha-beta T cell differentiation; purine salvage; purine base metabolic process

Disease: Purine Nucleoside Phosphorylase Deficiency
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 Research Articles on NP    1. insufficient data to evaluated impact of genetic polymorphisms on disease susceptibility
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NP antibodyPathways associated with anti-NP antibody
 Reference Product  PubMed Publications
 ADA antibody  >158 publications with NP and ADA
 HPRT1 antibody  >50 publications with NP and HPRT1
 APRT antibody  >16 publications with NP and APRT
 DCK antibody  >8 publications with NP and DCK
 GDA antibody  >3 publications with NP and GDA
 CDA antibody  >2 publications with NP and CDA
 ADK antibody  >1 publications with NP and ADK
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Purine Catabolism Pathway antibodies  Purine Catabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Salvage Pathway antibodies  Purine Salvage Pathway Diagram
Diseases associated with anti-NP antibodyOrgans/Tissues associated with anti-NP antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >207 publications with NP and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >77 publications with NP and Cardiovascular Diseases
 Brain Diseases Antibodies  >48 publications with NP and Brain Diseases
 Fibrosis Antibodies  >43 publications with NP and Fibrosis
 Purine Nucleoside Phosphorylase Deficiency Antibodies  >40 publications with NP and Purine Nucleoside Phosphorylase Deficiency
 Liver Diseases Antibodies  >34 publications with NP and Liver Diseases
 Neoplasms, Experimental Antibodies  >34 publications with NP and Neoplasms, Experimental
 Hyperplasia Antibodies  >33 publications with NP and Hyperplasia
 Necrosis Antibodies  >25 publications with NP and Necrosis
 Heart Diseases Antibodies  >24 publications with NP and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >556 publications with NP and Blood
 Liver Antibodies  >255 publications with NP and Liver
 Brain Antibodies  >158 publications with NP and Brain
 Heart Antibodies  >144 publications with NP and Heart
 Skin Antibodies  >114 publications with NP and Skin
 Vascular Antibodies  >87 publications with NP and Vascular
 Lung Antibodies  >75 publications with NP and Lung
 Kidney Antibodies  >72 publications with NP and Kidney
 Spleen Antibodies  >69 publications with NP and Spleen
 Bone Antibodies  >67 publications with NP and Bone
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