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anti-NR1H3 antibody :: Mouse anti-Human NR1H3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120075
Quality Control
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NR1H3, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human NR1H3

 Product Synonym Names    Homo sapiens nuclear receptor subfamily 1, group H, member 3 (NR1H3), mRNA; LXRA; LXR-a; RLD-1
 Product Gene Name   

anti-NR1H3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602423
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    NR1HB11D6
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-NR1H3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NR1H3 antibody

   Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-NR1H3 antibody   

Dot Blot (DB)

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 Quality Control of anti-NR1H3 antibody    Left: Western blot analysis of immunized recombinant protein, using anti-NR1H3 monoclonal antibody.
anti-NR1H3 antibody Quality Control image
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NCBI/Uniprot data below describe general gene information for NR1H3. It may not necessarily be applicable to this product.
 NCBI GI #    353731054
 NCBI GeneID    10062
 NCBI Accession #    NP_005684.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005693 [Other Products]
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 UniProt Secondary Accession #    Q8IW13; Q96H87; A8K3J9; D3DQR1 [Other Products]
 UniProt Related Accession #    Q13133 [Other Products]
 Molecular Weight    45,692 Da
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 NCBI Official Full Name    Homo sapiens nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    nuclear receptor subfamily 1, group H, member 3
 NCBI Official Symbol    NR1H3 [Similar Products]
 NCBI Official Synonym Symbols   
LXRA; LXR-a; RLD-1
[Similar Products]
 NCBI Protein Information    oxysterols receptor LXR-alpha; liver X nuclear receptor alpha variant 1
 UniProt Protein Name    Oxysterols receptor LXR-alpha
 UniProt Synonym Protein Names   
Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3
 Protein Family    Oxysterols receptor
 UniProt Gene Name    NR1H3 [Similar Products]
 UniProt Entry Name    NR1H3_HUMAN
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 NCBI Summary for NR1H3    The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for NR1H3    LXR-alpha: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: nucleoplasm; nuclear chromatin; nucleus; receptor complex

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; sterol response element binding; DNA binding; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; cholesterol binding; steroid hormone receptor activity

Biological Process: negative regulation of lipid transport; transcription initiation from RNA polymerase II promoter; positive regulation of fatty acid biosynthetic process; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; positive regulation of toll-like receptor 4 signaling pathway; lipid homeostasis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of pinocytosis; positive regulation of cholesterol transport; regulation of circadian rhythm; cholesterol homeostasis; negative regulation of inflammatory response; positive regulation of lipoprotein lipase activity; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; negative regulation of macrophage activation; sterol homeostasis; response to progesterone stimulus; apoptotic cell clearance
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 Research Articles on NR1H3    1. PRMT3 translocation by palmitic acid is coupled to the binding of LXRalpha, which is responsible for the onset of fatty liver.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NR1H3 antibodyPathways associated with anti-NR1H3 antibody
 Reference Product  PubMed Publications
 NR1H2 antibody  >42 publications with NR1H3 and NR1H2
 ABCA1 antibody  >18 publications with NR1H3 and ABCA1
 FASN antibody  >6 publications with NR1H3 and FASN
 CYP7A1 antibody  >3 publications with NR1H3 and CYP7A1
 REN antibody  >3 publications with NR1H3 and REN
 ABCG8 antibody  >2 publications with NR1H3 and ABCG8
 NR0B2 antibody  >2 publications with NR1H3 and NR0B2
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
Diseases associated with anti-NR1H3 antibodyOrgans/Tissues associated with anti-NR1H3 antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >18 publications with NR1H3 and Fatty Liver
 Inflammation Antibodies  >12 publications with NR1H3 and Inflammation
 Liver Diseases Antibodies  >12 publications with NR1H3 and Liver Diseases
 Atherosclerosis Antibodies  >8 publications with NR1H3 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >8 publications with NR1H3 and Cardiovascular Diseases
 Insulin Resistance Antibodies  >6 publications with NR1H3 and Insulin Resistance
 Hypercholesterolemia Antibodies  >5 publications with NR1H3 and Hypercholesterolemia
 Hypertriglyceridemia Antibodies  >4 publications with NR1H3 and Hypertriglyceridemia
 Heart Diseases Antibodies  >4 publications with NR1H3 and Heart Diseases
 Dyslipidemias Antibodies  >3 publications with NR1H3 and Dyslipidemias
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >75 publications with NR1H3 and Liver
 Blood Antibodies  >20 publications with NR1H3 and Blood
 Thyroid Antibodies  >9 publications with NR1H3 and Thyroid
 Brain Antibodies  >8 publications with NR1H3 and Brain
 Intestine Antibodies  >6 publications with NR1H3 and Intestine
 Heart Antibodies  >6 publications with NR1H3 and Heart
 Adipose Tissue Antibodies  >4 publications with NR1H3 and Adipose Tissue
 Ovary Antibodies  >4 publications with NR1H3 and Ovary
 Mammary Gland Antibodies  >3 publications with NR1H3 and Mammary Gland
 Kidney Antibodies  >3 publications with NR1H3 and Kidney
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