Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow NR4A1 rightarrow Monoclonal NR4A1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Testosterone 17-beta-dehydrogenase 3 (HSD17B3) Recombinant Protein
 • Cytokeratin 18, CK18 Recombinant Protein
 • Bcl-2 ELISA Kit
 • SCF ELISA Kit
 • CRP Antibody
 • Glucose-6-Phosphatase, Catalytic (G6PC) ELISA Kit
 • KIR3DL3 Antibody
 • Albumin Antibody
 • MUC2 (Mucin 2) Antibody
 • heparin-binding epidermal growth factor-like growth factor, ... ELISA Kit
 • PS1 ELISA Kit
 • CD40 Antibody
 • ALKBH3 Antibody
 • Blocking Buffer for ELISA Reagent
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-NR4A1 antibody :: Mouse anti-Human NR4A1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120078
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NR4A1, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human NR4A1

 Product Synonym Names    Homo sapiens nuclear receptor subfamily 4, group A, member 1 (NR4A1), transcript variant 1, mRNA; HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB
 Product Gene Name   

anti-NR4A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    139139
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    NR4AB9G12
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Concentration    100 ug/ml (1.0 ml) (lot specific)
Section Bar
 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
Section Bar
 Other Notes    Small volumes of anti-NR4A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-NR4A1 antibody

   This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two distinct isoforms have been identified for this gene. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-NR4A1 antibody   

Dot Blot (DB), Immunocytochemistry (ICC)

Section Bar
 Quality Control of anti-NR4A1 antibody    Left: Western blot analysis of immunized recombinant protein, using anti-NR4A1 monoclonal antibody.
anti-NR4A1 antibody Quality Control image
Section Bar
 Immunocytochemistry (ICC) of anti-NR4A1 antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-NR4A1 mAb. [Lot No.NR4AB9G12-2]
anti-NR4A1 antibody Immunocytochemistry (ICC) (ICC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for NR4A1. It may not necessarily be applicable to this product.
 NCBI GI #    320202953
 NCBI GeneID    3164
 NCBI Accession #    NP_002126.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002135 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q15627; Q53Y00; Q6IBU8; B4DML7 [Other Products]
 UniProt Related Accession #    P22736 [Other Products]
 Molecular Weight    33,754 Da
Table BarTOPTable Bar
 NCBI Official Full Name    Homo sapiens nuclear receptor subfamily 4, group A, member 1 (NR4A1), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    nuclear receptor subfamily 4, group A, member 1
 NCBI Official Symbol    NR4A1 [Similar Products]
 NCBI Official Synonym Symbols   
HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77
[Similar Products]
 NCBI Protein Information    nuclear receptor subfamily 4 group A member 1; ST-59; TR3 orphan receptor; early response protein NAK1; growth factor-inducible nuclear protein N10; hormone receptor; nerve growth factor IB nuclear receptor variant 1; nuclear hormone receptor NUR/77; orphan nuclear receptor HMR; orphan nuclear receptor TR3; steroid receptor TR3; testicular receptor 3
 UniProt Protein Name    Nuclear receptor subfamily 4 group A member 1
 UniProt Synonym Protein Names   
Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3
 Protein Family    Nuclear receptor subfamily
 UniProt Gene Name    NR4A1 [Similar Products]
 UniProt Entry Name    NR4A1_HUMAN
Section Bar
 NCBI Summary for NR4A1    This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Section Bar
 UniProt Comments for NR4A1    Nur77: an orphan nuclear receptor and immediate-early gene that regulates cellular proliferation, apoptosis, inflammation, and glucose metabolism. Induced by exercise in muscle and is a functional regulator of glucose metabolism in skeletal muscle. Its level decreases in the muscle of obese insulin-resistant men. Acts concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. A mediator of TCR-directed thymocyte apoptosis. TCR-signaling induces a FAIM/Akt/Nur77 signaling pathway that is critical for modulating apoptosis in developing thymocytes. A physiological substrate of the MEK-ERK-RSK cascade that modulates nuclear export and intracellular translocation during T cell death. Binds DNA as a monomer. Interacts with GADD45GIP1. Overexpression of Nur77 induces the expression of both p300 and HDAC1. Acetylation by p300 and HDAC1 may regulate the rapid turnover of Nur77 protein.

Protein type: Apoptosis; Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity

Biological Process: epidermal growth factor receptor signaling pathway; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; cell migration during sprouting angiogenesis; innate immune response; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression
Table BarTOPTable Bar
 Research Articles on NR4A1    1. our study demonstrated that Nur77 could promote the invasion and metastasis of colorectal cancer cells through regulation of MMP-9/E-cadherin signaling
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-NR4A1 antibodyPathways associated with anti-NR4A1 antibody
 Reference Product  PubMed Publications
 NR4A2 antibody  >139 publications with NR4A1 and NR4A2
 POMC antibody  >42 publications with NR4A1 and POMC
 MEF2D antibody  >7 publications with NR4A1 and MEF2D
 BCL2 antibody  >6 publications with NR4A1 and BCL2
 EP300 antibody  >4 publications with NR4A1 and EP300
 AKT1 antibody  >4 publications with NR4A1 and AKT1
 MED1 antibody  >1 publications with NR4A1 and MED1
 NR0B2 antibody  >1 publications with NR4A1 and NR0B2
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Nucleus Pathway antibodies  AKT Phosphorylates Targets In The Nucleus Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
Diseases associated with anti-NR4A1 antibodyOrgans/Tissues associated with anti-NR4A1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >65 publications with NR4A1 and Inflammation
 Cardiovascular Diseases Antibodies  >65 publications with NR4A1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >53 publications with NR4A1 and Nervous System Diseases
 Brain Diseases Antibodies  >45 publications with NR4A1 and Brain Diseases
 Necrosis Antibodies  >39 publications with NR4A1 and Necrosis
 Disease Models, Animal Antibodies  >37 publications with NR4A1 and Disease Models, Animal
 Atherosclerosis Antibodies  >30 publications with NR4A1 and Atherosclerosis
 Lung Diseases Antibodies  >18 publications with NR4A1 and Lung Diseases
 Liver Diseases Antibodies  >17 publications with NR4A1 and Liver Diseases
 Breast Neoplasms Antibodies  >16 publications with NR4A1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >187 publications with NR4A1 and Brain
 Blood Antibodies  >175 publications with NR4A1 and Blood
 Nerve Antibodies  >168 publications with NR4A1 and Nerve
 Thyroid Antibodies  >125 publications with NR4A1 and Thyroid
 Muscle Antibodies  >82 publications with NR4A1 and Muscle
 Liver Antibodies  >54 publications with NR4A1 and Liver
 Thymus Antibodies  >40 publications with NR4A1 and Thymus
 Adrenal Gland Antibodies  >40 publications with NR4A1 and Adrenal Gland
 Testis Antibodies  >33 publications with NR4A1 and Testis
 Lung Antibodies  >32 publications with NR4A1 and Lung
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions