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anti-NR4A2 antibody :: Mouse anti-Human NR4A2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120305
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NR4A2, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human NR4A2

 Product Synonym Names    Homo sapiens nuclear receptor subfamily 4, group A, member 2; NOT; RNR1; HZF-3; NURR1; TINUR
 Product Gene Name   

anti-NR4A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601828
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    447C2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-NR4A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NR4A2 antibody

   This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-NR4A2 antibody   

Dot Blot (DB), Western Blot (WB)

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 Quality Control of anti-NR4A2 antibody    Western blot analysis of immunized recombinant protein, using anti-NR4A2 monoclonal antibody.
anti-NR4A2 antibody Quality Control image
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 Quality Control #2 of anti-NR4A2 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-NR4A2 antibody Quality Control #2 image
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 Western Blot (WB) of anti-NR4A2 antibody    Detection of human NR4A2 by Western blot.

Samples: Whole cell lysate (25 ug) from HeLa cells. [Lot No. 447C2a-1]

Predicted molecular weight: 66 kDa
anti-NR4A2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NR4A2. It may not necessarily be applicable to this product.
 NCBI GI #    187423888
 NCBI GeneID    4929
 NCBI Accession #    NP_006177.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006186 [Other Products]
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 UniProt Secondary Accession #    Q16311; Q53RZ2; Q6NXU0 [Other Products]
 UniProt Related Accession #    P43354 [Other Products]
 Molecular Weight    59,809 Da
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 NCBI Official Full Name    Homo sapiens nuclear receptor subfamily 4, group A, member 2 (NR4A2), mRNA
 NCBI Official Synonym Full Names    nuclear receptor subfamily 4, group A, member 2
 NCBI Official Symbol    NR4A2 [Similar Products]
 NCBI Official Synonym Symbols   
NOT; RNR1; HZF-3; NURR1; TINUR
[Similar Products]
 NCBI Protein Information    nuclear receptor subfamily 4 group A member 2; NGFI-B/nur77 beta-type transcription factor homolog; T-cell nuclear receptor NOT; immediate-early response protein NOT; intermediate-early receptor protein; nuclear receptor related 1; nur related protein-1, human homolog of; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; transcriptionally inducible nuclear receptor related 1; transcriptionally-inducible nuclear receptor
 UniProt Protein Name    Nuclear receptor subfamily 4 group A member 2
 UniProt Synonym Protein Names   
Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor
 Protein Family    Nuclear receptor subfamily
 UniProt Gene Name    NR4A2 [Similar Products]
 UniProt Entry Name    NR4A2_HUMAN
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 NCBI Summary for NR4A2    This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NR4A2    NR4A2: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Belongs to the nuclear hormone receptor family. NR4 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 2q22-q23

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; zinc ion binding; protein heterodimerization activity; steroid hormone receptor activity

Biological Process: positive regulation of catalytic activity; adult locomotory behavior; neuron migration; dopamine biosynthetic process; response to insecticide; signal transduction; neuron maturation; post-embryonic development; regulation of respiratory gaseous exchange; general adaptation syndrome; negative regulation of neuron apoptosis; transcription initiation from RNA polymerase II promoter; response to inorganic substance; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; death; regulation of dopamine metabolic process; response to amphetamine; central nervous system projection neuron axonogenesis; habenula development; cellular response to extracellular stimulus; response to hypoxia; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; gene expression

Disease: Parkinson Disease, Late-onset
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 Research Articles on NR4A2    1. High cytoplasmic expression of NR4A2 is a potential unfavorable prognostic factor for patients with nasopharyngeal carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NR4A2 antibodyPathways associated with anti-NR4A2 antibody
 Reference Product  PubMed Publications
 NR4A1 antibody  >139 publications with NR4A2 and NR4A1
 FOSB antibody  >7 publications with NR4A2 and FOSB
 RORB antibody  >3 publications with NR4A2 and RORB
 NR5A1 antibody  >3 publications with NR4A2 and NR5A1
 PPARG antibody  >2 publications with NR4A2 and PPARG
 CDKN1C antibody  >2 publications with NR4A2 and CDKN1C
 Products by Pathway  Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
Diseases associated with anti-NR4A2 antibodyOrgans/Tissues associated with anti-NR4A2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >133 publications with NR4A2 and Nervous System Diseases
 Brain Diseases Antibodies  >121 publications with NR4A2 and Brain Diseases
 Movement Disorders Antibodies  >87 publications with NR4A2 and Movement Disorders
 Disease Models, Animal Antibodies  >46 publications with NR4A2 and Disease Models, Animal
 Inflammation Antibodies  >40 publications with NR4A2 and Inflammation
 Cardiovascular Diseases Antibodies  >23 publications with NR4A2 and Cardiovascular Diseases
 Necrosis Antibodies  >20 publications with NR4A2 and Necrosis
 Kidney Diseases Antibodies  >14 publications with NR4A2 and Kidney Diseases
 Atherosclerosis Antibodies  >11 publications with NR4A2 and Atherosclerosis
 Skin Diseases Antibodies  >10 publications with NR4A2 and Skin Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >279 publications with NR4A2 and Brain
 Nerve Antibodies  >144 publications with NR4A2 and Nerve
 Thyroid Antibodies  >58 publications with NR4A2 and Thyroid
 Blood Antibodies  >58 publications with NR4A2 and Blood
 Embryonic Tissue Antibodies  >42 publications with NR4A2 and Embryonic Tissue
 Vascular Antibodies  >28 publications with NR4A2 and Vascular
 Muscle Antibodies  >26 publications with NR4A2 and Muscle
 Kidney Antibodies  >24 publications with NR4A2 and Kidney
 Adrenal Gland Antibodies  >21 publications with NR4A2 and Adrenal Gland
 Liver Antibodies  >17 publications with NR4A2 and Liver
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