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anti-DEFA4 antibody :: Mouse anti-Rabbit Neutrophil Defensin 5 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS603525 anti-DEFA4 antibody
Unit / Price
0.1 mg  /  $835 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neutrophil Defensin 5 (DEFA4), Monoclonal Antibody

★Popular Item★
 Also Known As   

Neutrophil Defensin 5 (NP5)

 Product Synonym Names    Anti -Neutrophil Defensin 5 (NP5)
 Product Gene Name   

anti-DEFA4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 8; NC_000008.10 (6793345..6795786, complement). Location: 8p23
 OMIM    601157
 3D Structure    ModBase 3D Structure for P12838
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    6A609
 Host    Mouse
 Species Reactivity    Rabbit
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 Specificity    Recognizes natural, synthetic and recombinant rabbit Neutrophil Defensin 5. Reacts with natural NP-5 in biological solutions, in tissue sections and leukocyte smears fixed with ethanol, methanol/acetone or paraformaldehyde and in Flow Cytometry analysis of rabbit neutrophils stained by cell permeabilization method.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
 Concentration    0.1mg/ml (lot specific)
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 Immunogen    Rabbit Neutrophil Defensin 5 (NP5).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-DEFA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DEFA4 antibody

   Alpha defensins belong together with the beta-defensins to the family of cationic trisulfide-containing microbicidal peptides. They exert their microbicidal activity by permeating the membrane involving the formation of voltage regulated ion channels. Rabbit neutrophils contain large amount of alpha defensins (Neutrophil Defensin) NP 1-6. Defensins constitute more than 15% of total protein in rabbit neutrophils and are accumulated in dense cytoplasmic granules. Rabbit neutrophils express all six rabbit alpha-defensins, NP 1-6. Among myeloid rabbit alpha-defensins NP 1-6, NP 3-6 are neutrophil specific, while NP 1-2 are expressed in rabbit alveolar macrophages. Defensins are relatively resistant to proteolysis, low pH and boiling. Rabbit neutrophil defensins, whose three-dimensional structures are very similar to those of human alpha defensins may be helpful in understanding the role of antimicrobial peptides in innate and acquired immunity and in the studies on the role of neutrophils in pathological situations and in various rabbit models of human diseases.
 Product Categories/Family for anti-DEFA4 antibody    Antibodies; Abs to Defensin
 Applications Tested/Suitable for anti-DEFA4 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

 Application Notes for anti-DEFA4 antibody    Suitable for use in ELISA, Western Blot, Flow Cytometry and Immunohistochemistry.
Dilution: Western Blot: 1:10
Flow Cytometry: 1:10
Immunohistochemistry (Paraffin, frozen): 1:10
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NCBI/Uniprot data below describe general gene information for DEFA4. It may not necessarily be applicable to this product.
 NCBI GI #    4503303
 NCBI GeneID    1669
 NCBI Accession #    NP_001916.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001925.1 [Other Products]
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 UniProt Primary Accession #    P12838 [Other Products]
 UniProt Related Accession #    P12838 [Other Products]
 Molecular Weight    10,504 Da [Similar Products]
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 NCBI Official Full Name    neutrophil defensin 4 preproprotein
 NCBI Official Synonym Full Names    defensin, alpha 4, corticostatin
 NCBI Official Symbol    DEFA4 [Similar Products]
 NCBI Official Synonym Symbols   
HP4; DEF4; HP-4; HNP-4
[Similar Products]
 NCBI Protein Information    neutrophil defensin 4; corticostatin; defensin, alpha 4, preproprotein
 UniProt Protein Name    Neutrophil defensin 4
 UniProt Synonym Protein Names   
Defensin, alpha 4; HNP-4
 Protein Family    Neutrophil defensin
 UniProt Gene Name    DEFA4 [Similar Products]
 UniProt Synonym Gene Names    DEF4; HP-4 [Similar Products]
 UniProt Entry Name    DEF4_HUMAN
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 NCBI Summary for DEFA4    Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DEFA4    DEFA4: Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production. Belongs to the alpha-defensin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: extracellular space; Golgi lumen; extracellular region

Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus
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 Research Articles on DEFA4    1. Results indicate that the gene expression of DEFA 1/3 and 4 was significantly increased in all tumours - except for a significant decrease of DEFA 4 gene expression in pleomorphic adenomas.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DEFA4 antibodyPathways associated with anti-DEFA4 antibody
 Reference Product  PubMed Publications
 DEFB1 antibody  >3 publications with DEFA4 and DEFB1
 DEFA5 antibody  >2 publications with DEFA4 and DEFA5
 DEFA6 antibody  >2 publications with DEFA4 and DEFA6
 ELANE antibody  >1 publications with DEFA4 and ELANE
 CAMP antibody  >1 publications with DEFA4 and CAMP
 CEACAM8 antibody  >1 publications with DEFA4 and CEACAM8
 Products by Pathway  Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
Diseases associated with anti-DEFA4 antibodyOrgans/Tissues associated with anti-DEFA4 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with DEFA4 and Neoplasms
 Renal Insufficiency Antibodies  >1 publications with DEFA4 and Renal Insufficiency
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with DEFA4 and Blood
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