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anti-NOS1 antibody :: Mouse Nitric Oxide Synthase, Brain(1-181) NOS1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175003 anti-NOS1 antibody
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nitric Oxide Synthase, Brain(1-181) NOS1, Monoclonal Antibody

 Also Known As   

Anti-Nitric Oxide Synthase, Brain(1-181) NOS1 antibody (monoclonal)

 Product Synonym Names    Nitric oxide synthase, brain; nitric oxide synthase 1(neuronal); NOS; bNOS; nNOS; IHPS1; N-NOS; NC-NOS; Neuronal NOS; Peptidyl-cysteine S-nitrosylase NOS1
 Product Gene Name   

anti-NOS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    163731
 3D Structure    ModBase 3D Structure for P29475
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    N1
 Host    Mouse
 Species Reactivity    Human, Rat, Goat, Pig
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 Purity/Purification    Ascites
 Form/Format    Lyophilized
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 Immunogen    Recombinant neuronal NOS fragment (amino acids 1-181) from rat brain.
 Contents    Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
 Reconstitution    1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NOS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-NOS1 antibody

   Description: Mouse IgG monoclonal antibody for Nitric Oxide Synthase, Brain (1-181) NOS1, nitric oxide synthase 1 (neuronal) (NOS1) detection. Tested with WB in Human, rat, goat, pig. No cross reactivity with other proteins. Uniprot ID: P29475
Background: Nitric Oxide Synthase 1(NOS1,neuronal NOS,nNOS1) is a messenger molecule, mediating the effect of endothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. It may be involved in neuronal cell death and damage in neurological illness. nNOS1 localized to the 12q24.2 region of human chromosome 12. It splice variant, expressed in testis, that encodes an NH2-terminal truncated protein of 1098 amino acids. nNOS cDNA clones were shown to contain different 5' terminal exons spliced to a common exon 2. Genomic cloning and sequence analysis demonstrate that the unique exons are positioned within 300 bp of each other but separated from exon 2 by an intron that is at least 20 kb in length. The neuronal isoform of nitric oxide synthase is highly expressed in mammalian skeletal muscle, it suggested a specific role for NOS1 in the local metabolic inhibition of alpha-adrenergic vasoconstriction in active skeletal muscle. The novel gaseous neuromediator nitric oxide is though to play an important role in development and plasticity. Despite this, gene-knockout mice lacking neuronal(Type I) nitric oxide synthase exhibit relatively normal brain development and behavior.
 Applications Tested/Suitable for anti-NOS1 antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for NOS1. It may not necessarily be applicable to this product.
 NCBI GI #    1709333
 NCBI GeneID    4842
 NCBI Accession #    P29475.2 [Other Products]
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 UniProt Primary Accession #    P29475 [Other Products]
 UniProt Secondary Accession #    O75713; E9PH30 [Other Products]
 UniProt Related Accession #    P29475 [Other Products]
 Molecular Weight    164,779 Da
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 NCBI Official Full Name    Nitric oxide synthase, brain
 NCBI Official Synonym Full Names    nitric oxide synthase 1 (neuronal)
 NCBI Official Symbol    NOS1 [Similar Products]
 NCBI Official Synonym Symbols   
NOS; bNOS; nNOS; IHPS1; N-NOS; NC-NOS
[Similar Products]
 NCBI Protein Information    nitric oxide synthase, brain; NOS type I; neuronal NOS; constitutive NOS; peptidyl-cysteine S-nitrosylase NOS1
 UniProt Protein Name    Nitric oxide synthase, brain
 UniProt Synonym Protein Names   
Constitutive NOS; NC-NOS; NOS type I; Neuronal NOS; N-NOS; nNOS; Peptidyl-cysteine S-nitrosylase NOS1; bNOS
 Protein Family    Nitric oxide synthase
 UniProt Gene Name    NOS1 [Similar Products]
 UniProt Synonym Gene Names    N-NOS; nNOS [Similar Products]
 UniProt Entry Name    NOS1_HUMAN
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 NCBI Summary for NOS1    The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
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 UniProt Comments for NOS1    nNOS: nitric oxide synthase 1, neuronal form. Produces nitric oxide which is a messenger molecule with diverse functions and displays many properties of a neurotransmitter in the brain and peripheral nervous system. May be an effector enzyme for the dystrophin complex. Four alternatively spliced isoforms have been described.

Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q24.22

Cellular Component: protein complex; photoreceptor inner segment; cytoskeleton; sarcoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; cytoplasm; dendritic spine; synapse; cytosol; sarcolemma; lipid raft

Molecular Function: calmodulin binding; protein binding; FAD binding; sodium channel regulator activity; FMN binding; NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; iron ion binding; heme binding; oxidoreductase activity; NADP binding; cadmium ion binding

Biological Process: negative regulation of serotonin uptake; interaction with host; negative regulation of calcium ion transport; striated muscle contraction; positive regulation of transcription, DNA-dependent; negative regulation of potassium ion transport; positive regulation of guanylate cyclase activity; regulation of sodium ion transport; positive regulation of vasodilation; response to heat; negative regulation of hydrolase activity; exogenous drug catabolic process; response to hypoxia; peptidyl-cysteine S-nitrosylation; arginine catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation; negative regulation of blood pressure; blood coagulation; nitric oxide biosynthetic process; multicellular organismal response to stress; nitric oxide mediated signal transduction; myoblast fusion; neurotransmitter biosynthetic process

Disease: Pyloric Stenosis, Infantile Hypertrophic, 1
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 Research Articles on NOS1    1. The resukts of this study demonistrated that the risk allele significantly decreases expression of NOS1 in the prefrontal cortex in patient with schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NOS1 antibodyPathways associated with anti-NOS1 antibody
 Reference Product  PubMed Publications
 CAV3 antibody  >7 publications with NOS1 and CAV3
 ARG1 antibody  >6 publications with NOS1 and ARG1
 UBC antibody  >3 publications with NOS1 and UBC
 DLG4 antibody  >2 publications with NOS1 and DLG4
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
Diseases associated with anti-NOS1 antibodyOrgans/Tissues associated with anti-NOS1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >492 publications with NOS1 and Nervous System Diseases
 Brain Diseases Antibodies  >261 publications with NOS1 and Brain Diseases
 Disease Models, Animal Antibodies  >232 publications with NOS1 and Disease Models, Animal
 Hypertension Antibodies  >160 publications with NOS1 and Hypertension
 Mental Disorders Antibodies  >153 publications with NOS1 and Mental Disorders
 Inflammation Antibodies  >130 publications with NOS1 and Inflammation
 Brain Ischemia Antibodies  >105 publications with NOS1 and Brain Ischemia
 Heart Diseases Antibodies  >94 publications with NOS1 and Heart Diseases
 Pain Antibodies  >92 publications with NOS1 and Pain
 Kidney Diseases Antibodies  >60 publications with NOS1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1102 publications with NOS1 and Brain
 Muscle Antibodies  >482 publications with NOS1 and Muscle
 Kidney Antibodies  >213 publications with NOS1 and Kidney
 Lung Antibodies  >79 publications with NOS1 and Lung
 Uterus Antibodies  >15 publications with NOS1 and Uterus
 Ovary Antibodies  >13 publications with NOS1 and Ovary
 Prostate Antibodies  >7 publications with NOS1 and Prostate
 Uncharacterized Tissue Antibodies  >3 publications with NOS1 and Uncharacterized Tissue
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