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anti-Nuclear stain of multiple gene products including Nup62, Nup133 antibody :: Mouse Nuclear pore Complex Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS500029
Testing Data
Unit / Price
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Nuclear pore Complex (Nuclear stain of multiple gene products including Nup62, Nup133), Monoclonal Antibody

 Also Known As   

Anti-Nuclear Pore Complex

 Product Gene Name   

anti-Nuclear stain of multiple gene products including Nup62, Nup133 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    39C7
 Host    Mouse
 Species Reactivity    Human, mouse, rat
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 Specificity    Reacts with nuclear pore complex proteins
 Purity/Purification    Total IgG fraction (Concentrated culture supernatant.)
 Form/Format    Liquid. Contains 10 mM sodium azide
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 Antigen    Yeast nuclear preparations
 Immunogen Information    Yeast nuclear preparations
 Immunogen Species    Yeast
 Species Reactivity Note    The antibody has been directly tested for reactivity in human, mouse, rat and yeast.
 Biological Significance    The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993; Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001).
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 Preparation and Storage    Store at -20 degree C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-Nuclear stain of multiple gene products including Nup62, Nup133 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Nuclear stain of multiple gene products including Nup62, Nup133 antibody

   Mouse monoclonal antibody
 Applications Tested/Suitable for anti-Nuclear stain of multiple gene products including Nup62, Nup133 antibody   

Immunofluorescence (IF)

 Application Notes for anti-Nuclear stain of multiple gene products including Nup62, Nup133 antibody    Quality Control: Immunofluorescence performed on each lot.
IF: 1:50-1:100
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 Testing Data of anti-Nuclear stain of multiple gene products including Nup62, Nup133 antibody    anti-Nuclear stain of multiple gene products including Nup62, Nup133 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for Nuclear stain of multiple gene products including Nup62, Nup133. It may not necessarily be applicable to this product.
 NCBI GI #    477526818
 NCBI Accession #    ENH78671.1 [Other Products]
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 NCBI Official Full Name    nuclear pore complex
 Protein Family    Nuclear pore complex protein
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Product References and Citations for anti-Nuclear stain of multiple gene products including Nup62, Nup133 antibody

   • Nakielny S, Dreyfuss G (1999) Transport of proteins and RNAs in and out of the nucleus. Cell 99(7):677-690.
• Wilken N, Kossner U, Senecal JL, Scheer U, Dabauvalle MC (1993) Nup180, a novel nuclear pore complex protein localizing to the cytoplasmic ring and associated fibrils. J Cell Biol 123(6 pt 1):1345-54.
• Nesher G, Margalit R, Ashkenazi YJ (2001) Anti-nuclear envelope antibodies: Clinical associations. Semin Arthritis Rheum 30(5):313-20.
• Jaju RJ, Fidler C, Haas OA, Strickson AJ, Watkins F, Clark K, Cross NC, Cheng JF, Aplan PD, Kearney L, Boultwood J, Wainscoat JS (2001) A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. Blood 98(4):1264-7.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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