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anti-CDH11 antibody :: Mouse anti-Human, Rat OB-Cadherin / Cadherin-11 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS570013
Unit / Price
1 mL  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OB-Cadherin / Cadherin-11 (CDH11), Monoclonal Antibody

 Also Known As   

Mouse anti OB-Cadherin / Cadherin-11

 Product Gene Name   

anti-CDH11 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (64980683..65155919, complement). Location: 16q21
 OMIM    600023
 3D Structure    ModBase 3D Structure for P55287
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    16A
 Host    Mouse
 Species Reactivity    Human, Rat
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 Specificity    16A recognizes the extracellular domain of cadherin-11.
 Form/Format    Each vial contains 1ml of culture supernatant of monoclonal antibody containing 0.09% sodium azide.
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 Product Type    Primary Antibody
 Host Note    16A is a Mouse monoclonal IgG1 antibody obtained by fusion of SP2/0 Mouse myeloma cells with spleen cells from a Mouse immunized with affinity purified extracellular domain of Human cadherin-11-GST fusion protein.
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 Preparation and Storage    Store at 4 degree C, or in small aliquots at -20 degree C.
 Other Notes    Small volumes of anti-CDH11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CDH11 antibody

   Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the Catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. The progression of carcinomas is associated with the loss of epithelial morphology and a concomitant acquisition of a more mesenchymal phenotype, which is thought to contribute to the invasive and/or metastatic behavior. A putative role for cadherin-11 in these late stages of tumor progression is based on the fact that migRation of mesenchymal cells is facilitated when cadherin-11 is highly expressed.
 Product Categories/Family for anti-CDH11 antibody    Cell adhesion, Cell adhesion
 Applications Tested/Suitable for anti-CDH11 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) (frozen), Immunoblotting

 Application Notes for anti-CDH11 antibody    16A is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen sections when using a PBS buffer containing 0.1 mM CaCl2 and 0.1 mM MgCl2. Optimal antibody dilution should be determined by titRation; recommended range is 1:2 - 1:5 for immunohistochemistry with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent, and 1:2 - 1:25 for immunoblotting appliCations.
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 Testing Data of anti-CDH11 antibody    Figure 1: Immunocytochemistry on Cadherin 11 transfected PC3 cells
anti-CDH11 antibody Testing Data image
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 Testing Data of anti-CDH11 antibody    Figure 2: Western blot on a lysate of Cadherin 11 transfected PC3 cells
anti-CDH11 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CDH11. It may not necessarily be applicable to this product.
 NCBI GI #    16306532
 NCBI GeneID    1009
 NCBI Accession #    NP_001788.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001797.2 [Other Products]
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 UniProt Primary Accession #    P55287 [Other Products]
 UniProt Secondary Accession #    Q15065; Q15066; Q9UQ93; Q9UQ94; A8K5D6; A8MZC8; B7WP28 [Other Products]
 UniProt Related Accession #    P55287; Q59EQ1; Q96CZ9 [Other Products]
 Molecular Weight    87,965 Da [Similar Products]
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 NCBI Official Full Name    cadherin-11 preproprotein
 NCBI Official Synonym Full Names    cadherin 11, type 2, OB-cadherin (osteoblast)
 NCBI Official Symbol    CDH11 [Similar Products]
 NCBI Official Synonym Symbols   
OB; CAD11; CDHOB; OSF-4
[Similar Products]
 NCBI Protein Information    cadherin-11; OTTHUMP00000174770; OTTHUMP00000174771
 UniProt Protein Name    Cadherin-11
 UniProt Synonym Protein Names   
OSF-4; Osteoblast cadherin
 Protein Family    Cadherin
 UniProt Gene Name    CDH11 [Similar Products]
 UniProt Entry Name    CAD11_HUMAN
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 NCBI Summary for CDH11    This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq]
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 UniProt Comments for CDH11    CDH11: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with PCDH8. Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: cytoplasm; plasma membrane; integral to membrane

Molecular Function: calcium ion binding

Biological Process: intercellular junction assembly and maintenance; ossification; cell adhesion; corticospinal tract morphogenesis; homophilic cell adhesion; skeletal development
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Product References and Citations for anti-CDH11 antibody

   Bussemakers, M. J., Van Bokhoven, A., Tomita, K., Jansen, C. F., and Schalken, J. A. (2000). Complex cadherin expression in Human prostate cancer cells, Int J Cancer 85, 446-50. Tomita, K., van Bokhoven, A., van Leenders, G. J., Ruijter, E. T., Jansen, C. F., Bussemakers, M. J., and Schalken, J. A. (2000). Cadherin switching in Human prostate cancer progression, Cancer Res 60, 3650-4.
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 Research Articles on CDH11    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDH11 antibodyPathways associated with anti-CDH11 antibody
 Reference Product  PubMed Publications
 CDH2 antibody  >2 publications with CDH11 and CDH2
 CTNNB1 antibody  >2 publications with CDH11 and CTNNB1
 Products by Pathway  Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
Diseases associated with anti-CDH11 antibodyOrgans/Tissues associated with anti-CDH11 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >16 publications with CDH11 and Neoplasms
 Carcinoma Antibodies  >5 publications with CDH11 and Carcinoma
 Bone Neoplasms Antibodies  >4 publications with CDH11 and Bone Neoplasms
 Adenocarcinoma Antibodies  >3 publications with CDH11 and Adenocarcinoma
 Translocation, Genetic Antibodies  >3 publications with CDH11 and Translocation, Genetic
 Breast Neoplasms Antibodies  >2 publications with CDH11 and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >1 publications with CDH11 and Carcinoma, Squamous Cell
 Head and Neck Neoplasms Antibodies  >1 publications with CDH11 and Head and Neck Neoplasms
 Lung Neoplasms Antibodies  >1 publications with CDH11 and Lung Neoplasms
 Precancerous Conditions Antibodies  >1 publications with CDH11 and Precancerous Conditions
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >9 publications with CDH11 and Bone
 Brain Antibodies  >5 publications with CDH11 and Brain
 Eye Antibodies  >4 publications with CDH11 and Eye
 Embryonic Tissue Antibodies  >3 publications with CDH11 and Embryonic Tissue
 Bone Marrow Antibodies  >2 publications with CDH11 and Bone Marrow
 Placenta Antibodies  >2 publications with CDH11 and Placenta
 Intestine Antibodies  >1 publications with CDH11 and Intestine
 Uncharacterized Tissue Antibodies  >1 publications with CDH11 and Uncharacterized Tissue
 Muscle Antibodies  >1 publications with CDH11 and Muscle
 Skin Antibodies  >1 publications with CDH11 and Skin
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