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anti-POU2F2 antibody :: Mouse anti-Human OCT-2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS632358 anti-POU2F2 antibody
Unit / Price
1 mL  /  $1,305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OCT-2 (POU2F2), Monoclonal Antibody

 Also Known As   

Oct-2 (Octamer-binding transcription factor 2, Oct-2, OTF-2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2)

 Product Synonym Names    Anti -Oct-2 (Octamer-binding transcription factor 2, Oct-2, OTF-2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2)
 Product Gene Name   

anti-POU2F2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (42592650..42636630, complement). Location: 19q13.2
 OMIM    164176
 3D Structure    ModBase 3D Structure for P09086
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    MRQ-2
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human Oct-2 (Octamer-binding transcription factor 2, Oct-2, OTF-2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2).
 Purity/Purification    Ascites
Ascites
 Form/Format    Supplied as a liquid in PBS, pH7.4, protein base, sodium azide.
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 Positive Control    Tonsil, lymph node
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-POU2F2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-POU2F2 antibody

   Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. These are involved in proliferation and differentiation and despite the scarce evidence for Oct-2 expression in T cells, it has been shown that this factor participates in transcriptional regulation during T-cell activation. Oct-2 activity is dependent on phosphorylation and alternatitive splicing, although it seems that the level of its expression can be used as a marker of B-cell lineage and differentiation. The following show high levels of Oct-2 expression: germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells. Various lymphomas are also positive for this marker including the following: B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, classic Hodgkin lymphoma.

Several studies of Oct-2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines display high levels of expression. Analysis of Oct-2 expression in primary Hodgkin's lymphoma (HLs) and cell lines derived from it showed that the tumor cells analyzed had high levels of expression and activity, suggesting a common B-cell origin for all types of HLs.
 Product Categories/Family for anti-POU2F2 antibody    Antibodies; Abs to Ion Channel
 Applications Tested/Suitable for anti-POU2F2 antibody   

Immunohistochemistry (IHC)

 Application Notes for anti-POU2F2 antibody    Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry (Paraffin, frozen): 1:25-1:100
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NCBI/Uniprot data below describe general gene information for POU2F2. It may not necessarily be applicable to this product.
 NCBI GI #    4379032
 NCBI GeneID    5452
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 UniProt Primary Accession #    P09086 [Other Products]
 UniProt Secondary Accession #    Q16648; Q7M4M8; Q9BRS4 [Other Products]
 UniProt Related Accession #    P09086; Q16624; Q9UMI6; Q9UMJ4 [Other Products]
 Molecular Weight    51,209 Da [Similar Products]
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 NCBI Official Full Name    Oct-2
 NCBI Official Synonym Full Names    POU class 2 homeobox 2
 NCBI Official Symbol    POU2F2 [Similar Products]
 NCBI Official Synonym Symbols   
OCT2; OTF2; Oct-2
[Similar Products]
 NCBI Protein Information    POU domain, class 2, transcription factor 2; OTF-2; homeobox protein; OTTHUMP00000231645; OTTHUMP00000231646; OTTHUMP00000231647; OTTHUMP00000231648; OTTHUMP00000231650; octamer-binding protein 2; octamer-binding transcription factor 2; lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
 UniProt Protein Name    POU domain, class 2, transcription factor 2
 UniProt Synonym Protein Names   
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Octamer-binding protein 2; Oct-2; Octamer-binding transcription factor 2
 Protein Family    POU domain, class 2, transcription factor
 UniProt Gene Name    POU2F2 [Similar Products]
 UniProt Synonym Gene Names    OCT2; OTF2 [Similar Products]
 UniProt Entry Name    PO2F2_HUMAN
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 NCBI Summary for POU2F2    The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for POU2F2    Oct2: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Belongs to the POU transcription factor family. Class- 2 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein domain specific binding; sequence-specific DNA binding; transcription factor activity

Biological Process: immunoglobulin secretion during immune response; transcription from RNA polymerase II promoter; mature B cell differentiation; positive regulation of transcription, DNA-dependent; cell maturation; humoral immune response
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 Research Articles on POU2F2    1. Twenty-two cases of nodular lymphocyte predominant Hodgkin lymphoma were studied for the immunohistochemical expression of Pax-5, Oct-2, BOB.1, Bcl-6 protein and MUM1/IRF-4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-POU2F2 antibodyPathways associated with anti-POU2F2 antibody
 Reference Product  PubMed Publications
 POU2AF1 antibody  >35 publications with POU2F2 and POU2AF1
 TBP antibody  >4 publications with POU2F2 and TBP
 HMGB2 antibody  >1 publications with POU2F2 and HMGB2
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
Diseases associated with anti-POU2F2 antibodyOrgans/Tissues associated with anti-POU2F2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >40 publications with POU2F2 and Neoplasms
 Hodgkin Disease Antibodies  >11 publications with POU2F2 and Hodgkin Disease
 Vascular Diseases Antibodies  >4 publications with POU2F2 and Vascular Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with POU2F2 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >3 publications with POU2F2 and Neoplasms, Experimental
 Melanoma Antibodies  >2 publications with POU2F2 and Melanoma
 Liver Neoplasms Antibodies  >1 publications with POU2F2 and Liver Neoplasms
 Breast Neoplasms Antibodies  >1 publications with POU2F2 and Breast Neoplasms
 Genital Neoplasms, Female Antibodies  >1 publications with POU2F2 and Genital Neoplasms, Female
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >114 publications with POU2F2 and Blood
 Brain Antibodies  >20 publications with POU2F2 and Brain
 Lymph Node Antibodies  >7 publications with POU2F2 and Lymph Node
 Lymph Antibodies  >6 publications with POU2F2 and Lymph
 Bone Antibodies  >6 publications with POU2F2 and Bone
 Embryonic Tissue Antibodies  >3 publications with POU2F2 and Embryonic Tissue
 Liver Antibodies  >3 publications with POU2F2 and Liver
 Tonsil Antibodies  >2 publications with POU2F2 and Tonsil
 Testis Antibodies  >2 publications with POU2F2 and Testis
 Skin Antibodies  >2 publications with POU2F2 and Skin
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