NP_006181.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,972 Da
NCBI Official Full Name
origin recognition complex subunit 2
NCBI Official Synonym Full Names
origin recognition complex, subunit 2
NCBI Official Synonym Symbols
NCBI Protein Information
origin recognition complex subunit 2; origin recognition complex protein 2 homolog; origin recognition complex, subunit 2 homolog
UniProt Protein Name
Origin recognition complex subunit 2
UniProt Synonym Gene Names
UniProt Entry Name
ORC2_HUMAN
NCBI Summary for ORC2
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]
UniProt Comments for ORC2
ORC2: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Interacts with MCM10. Belongs to the ORC2 family.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 2q33
Cellular Component: nucleoplasm; heterochromatin; membrane; inner kinetochore of condensed chromosome; plasma membrane; nuclear origin of replication recognition complex; nucleus; origin recognition complex
Molecular Function: protein binding; DNA replication origin binding
Biological Process: DNA replication initiation; negative regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle
Product References and Citations for anti-ORC2 antibody
Song W et al. A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes. J Biol Chem 282:22721-30 (2007). WB ; Human PUBMED
Research Articles on ORC2
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Products associated with anti-ORC2 antibody
Pathways associated with anti-ORC2 antibody
Diseases associated with anti-ORC2 antibody
Organs/Tissues associated with anti-ORC2 antibody
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