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anti-ORC3L antibody :: Rat anti-Human ORC3L Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS375198
Testing Data
Unit / Price
0.05 mL  /  $370 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ORC3L, Monoclonal Antibody

★Popular Item★
 Also Known As   

Rat Anti-ORC3L [1D6]

 Product Synonym Names    Homolog of Latheo antibody; homolog of latheo, Drosophila antibody; LAT antibody; LATHEOantibody; LATHEO, drosophila, homolog of antibody; Orc3 antibody; Origin recognition complex subunit 3antibody; Origin Recognition Complex Subunit 3 Isoform 1 antibody; Origin recognition complex subunit Latheoantibody; Origin Recognition Complex, subunit 3, S. cerevisiae, homolog of antibody; Origin recognition complex,subunit 3-like (S. cerevisiae) antibody; Origin recognition complex, subunit 3-like (yeast)antibody
 Product Gene Name   

anti-ORC3L antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604972
 3D Structure    ModBase 3D Structure for Q9UBD5
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    1D6
 Host    Rat
 Species Reactivity    Human
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 Purity/Purification    Protein G
 Form/Format    Purified antibody containing PBS 0.1% sodium azide
 Concentration    0.1mg/ml (lot specific)
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 Target Antigen    ORC3L
 Immunogen    Full length human ORC3L protein
 Myeloma/fusion Partners    P3-x63Ag.8.653
 Research Areas    DNA Synthesis
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 Other Notes    Small volumes of anti-ORC3L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ORC3L antibody   

Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-ORC3L antibody    Optimal antibody dilution should be determined by titration, however as a guideline try; WB: Use at 1:1000. Predicted molecular weight: 82 kDa
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 Testing Data of anti-ORC3L antibody    anti-ORC3L antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ORC3L. It may not necessarily be applicable to this product.
 NCBI GI #    308737003
 NCBI GeneID    23595
 NCBI Accession #    NP_001184188.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001197259.1 [Other Products]
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 UniProt Primary Accession #    Q9UBD5 [Other Products]
 UniProt Secondary Accession #    Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UG44; Q9UNT6; A2A2T5; B4E025 [Other Products]
 UniProt Related Accession #    Q9UBD5 [Other Products]
 Molecular Weight    65,929 Da
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 NCBI Official Full Name    origin recognition complex subunit 3 isoform 3
 NCBI Official Synonym Full Names    origin recognition complex, subunit 3
 NCBI Official Symbol    ORC3 [Similar Products]
 NCBI Official Synonym Symbols   
LAT; ORC3L; LATHEO
[Similar Products]
 NCBI Protein Information    origin recognition complex subunit 3; homolog of latheo, Drosophila; origin recognition complex subunit Latheo; origin recognition complex, subunit 3 honolog
 UniProt Protein Name    Origin recognition complex subunit 3
 UniProt Synonym Protein Names   
Origin recognition complex subunit Latheo
 UniProt Gene Name    ORC3 [Similar Products]
 UniProt Synonym Gene Names    LATHEO; ORC3L [Similar Products]
 UniProt Entry Name    ORC3_HUMAN
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 NCBI Summary for ORC3L    The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ORC3L    ORC3L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Belongs to the ORC3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 6q14.3-q16.1

Cellular Component: nucleoplasm; nuclear origin of replication recognition complex; origin recognition complex

Molecular Function: protein binding; DNA replication origin binding

Biological Process: mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle
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Product References and Citations for anti-ORC3L antibody

   Human origin recognition complex binds to the region of the latent origin of DNA replication of EpsteinBarr virus. Schepers A et al. (Embo J,Aug 2001)PUBMED
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 Research Articles on ORC3L    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ORC3L antibodyOrgans/Tissues associated with anti-ORC3L antibody
 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Assembly Of The ORC Complex At The Origin Of Replication Pathway antibodies  Assembly Of The ORC Complex At The Origin Of Replication Pathway Diagram
 Assembly Of The Pre-replicative Complex Pathway antibodies  Assembly Of The Pre-replicative Complex Pathway Diagram
 Association Of Licensing Factors With The Pre-replicative Complex Pathway antibodies  Association Of Licensing Factors With The Pre-replicative Complex Pathway Diagram
 CDC6 Association With The ORC:origin Complex Pathway antibodies  CDC6 Association With The ORC:origin Complex Pathway Diagram
 CDT1 Association With The CDC6:ORC:origin Complex Pathway antibodies  CDT1 Association With The CDC6:ORC:origin Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with ORC3L and Brain
 Nerve Antibodies  >2 publications with ORC3L and Nerve
 Blood Antibodies  >2 publications with ORC3L and Blood
 Embryonic Tissue Antibodies  >2 publications with ORC3L and Embryonic Tissue
 Vascular Antibodies  >2 publications with ORC3L and Vascular
 Ovary Antibodies  >1 publications with ORC3L and Ovary
 Thymus Antibodies  >1 publications with ORC3L and Thymus
 Eye Antibodies  >1 publications with ORC3L and Eye
 Kidney Antibodies  >1 publications with ORC3L and Kidney
 Bone Antibodies  >1 publications with ORC3L and Bone
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