AAB00195.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
occludin
NCBI Official Synonym Full Names
occludin
NCBI Protein Information
occludin
UniProt Protein Name
Occludin
UniProt Entry Name
OCLN_HUMAN
NCBI Summary for OCLN
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]
UniProt Comments for OCLN
occludin: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. Interacts with TJP1/ZO1 and with VAPA. Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis. Belongs to the ELL/occludin family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 5q13.1
Cellular Component: tight junction; endocytic vesicle; apicolateral plasma membrane; apical plasma membrane; plasma membrane; integral to membrane; cytoplasmic vesicle; intercellular junction; cell junction; cytosol
Molecular Function: thiopurine S-methyltransferase activity; protein domain specific binding; protein binding; structural molecule activity
Biological Process: methylation; intercellular junction assembly and maintenance; apoptosis; S-adenosylmethionine metabolic process; S-adenosylhomocysteine metabolic process; protein complex assembly; cell structure disassembly during apoptosis
Disease: Band-like Calcification With Simplified Gyration And Polymicrogyria
Research Articles on OCLN
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Pathways associated with anti-OCLN antibody
Diseases associated with anti-OCLN antibody
Organs/Tissues associated with anti-OCLN antibody
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