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anti-CDH3 antibody :: Mouse P-Cadherin (CDH3) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS439064
SDS-Page
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

P-Cadherin (CDH3), Monoclonal Antibody

★Popular Item★
 Also Known As   

P-Cadherin (CDH3)

 Product Synonym Names    Cadherin 3 type 1; Cadherin-3; Cadp; Calcium dependent adhesion protein placental; CDH3; CDHP; HJMD; P-cadherin (Placental); PCAD; Placental cadherin
 Product Gene Name   

anti-CDH3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P22223
 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    12H6
 Host    Mouse
 Species Reactivity    Human. Others not known.
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 Specificity    Recognizes a protein of 116kDa, identified as P-Cadherin-1 (CDH3). It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congenital hypotrichosis with juvenile macular dystrophy.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant human full-length P-cadherin fusion protein
 Cellular Localization    Cell Surface
 Hu-chromosome Location    16q22.1
 Positive Control    A431 or PC-3 cells. Pancreas, Placenta or Prostate
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-CDH3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CDH3 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-CDH3 antibody    FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
WB: 0.5-1.0ug/ml
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 SDS-Page of anti-CDH3 antibody    SDS-PAGE Analysis of Purified Chromogranin A Mouse Recombinant Monoclonal Antibody (rCHGA/413).
anti-CDH3 antibody SDS-Page image
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NCBI/Uniprot data below describe general gene information for CDH3. It may not necessarily be applicable to this product.
 NCBI GI #    953953841
 NCBI GeneID    1001
 NCBI Accession #    NP_001304124.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001317195.1 [Other Products]
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 UniProt Primary Accession #    P22223 [Other Products]
 UniProt Secondary Accession #    Q05DI6; B2R6F4 [Other Products]
 UniProt Related Accession #    P22223 [Other Products]
 Molecular Weight    116kDa
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 NCBI Official Full Name    cadherin-3 isoform 2
 NCBI Official Synonym Full Names    cadherin 3
 NCBI Official Symbol    CDH3 [Similar Products]
 NCBI Official Synonym Symbols   
CDHP; HJMD; PCAD
[Similar Products]
 NCBI Protein Information    cadherin-3
 UniProt Protein Name    Cadherin-3
 UniProt Synonym Protein Names   
Placental cadherin; P-cadherin
 UniProt Gene Name    CDH3 [Similar Products]
 UniProt Synonym Gene Names    CDHP; P-cadherin [Similar Products]
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 NCBI Summary for CDH3    This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]
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 UniProt Comments for CDH3    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
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Product References and Citations for anti-CDH3 antibody

   Sanders DS, Perry I, Hardy R, Jankowski J. Aberrant P-cadherin expression is a feature of clonal expansion in the gastrointestinal tract associated with repair and neoplasia. J Pathol. 2000 Apr; 190(5):526-30.
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 Research Articles on CDH3    1. the evaluation of P-cadherin expression in lymph node metastases is an important predictor of disease outcome in breast cancer axillary lymph node metastases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDH3 antibodyPathways associated with anti-CDH3 antibody
 Reference Product  PubMed Publications
 CDH1 antibody  >23 publications with CDH3 and CDH1
 CTNNB1 antibody  >4 publications with CDH3 and CTNNB1
 CDH11 antibody  >3 publications with CDH3 and CDH11
 CDH5 antibody  >2 publications with CDH3 and CDH5
 CDH13 antibody  >2 publications with CDH3 and CDH13
 CDH8 antibody  >1 publications with CDH3 and CDH8
 Products by Pathway  Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
Diseases associated with anti-CDH3 antibodyOrgans/Tissues associated with anti-CDH3 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >15 publications with CDH3 and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >6 publications with CDH3 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >5 publications with CDH3 and Lung Neoplasms
 Lung Diseases Antibodies  >5 publications with CDH3 and Lung Diseases
 Neoplasm Metastasis Antibodies  >5 publications with CDH3 and Neoplasm Metastasis
 Ectodermal dysplasia, ectrodactyly, and macular dystrophy Antibodies  >5 publications with CDH3 and Ectodermal dysplasia, ectrodactyly, and macular dystrophy
 Neoplasms, Experimental Antibodies  >4 publications with CDH3 and Neoplasms, Experimental
 Inflammation Antibodies  >4 publications with CDH3 and Inflammation
 Chromosome Aberrations Antibodies  >4 publications with CDH3 and Chromosome Aberrations
 Precancerous Conditions Antibodies  >3 publications with CDH3 and Precancerous Conditions
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >9 publications with CDH3 and Eye
 Skin Antibodies  >8 publications with CDH3 and Skin
 Lung Antibodies  >6 publications with CDH3 and Lung
 Liver Antibodies  >6 publications with CDH3 and Liver
 Intestine Antibodies  >6 publications with CDH3 and Intestine
 Blood Antibodies  >5 publications with CDH3 and Blood
 Stomach Antibodies  >4 publications with CDH3 and Stomach
 Embryonic Tissue Antibodies  >4 publications with CDH3 and Embryonic Tissue
 Prostate Antibodies  >3 publications with CDH3 and Prostate
 Thyroid Antibodies  >3 publications with CDH3 and Thyroid
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