NP_001032898.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cadherin-3 isoform a preproprotein
NCBI Official Synonym Full Names
cadherin 3
NCBI Official Synonym Symbols
Cadp; Cdhp; Pcad; AI385538; P-cadherin [Similar Products]
NCBI Protein Information
cadherin-3; placental cadherin; RPE-specific cadherin
UniProt Protein Name
Cadherin-3
UniProt Synonym Protein Names
Placental cadherin
UniProt Synonym Gene Names
UniProt Entry Name
CADH3_MOUSE
NCBI Summary for Cdh3
This gene encodes a calcium-dependent cell-cell adhesion protein containing five cadherin domains. The encoded protein plays a role in epithelial outgrowth, such as that which occurs during the development of hair follicles and limb buds. Loss of function of the related gene in humans results in ectodermal dysplasia, ectrodactyly, and macular dystrophy and congential hypotrichosis with juvenile macular dystrophy. This gene is located in the vicinity of similar cadherin genes on chromosome 8. The proprotein is further cleaved into a functional chain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
UniProt Comments for Cdh3
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subunit structure: Interacts with CDCP1 and CTNNB1
By similarity.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Developmental stage: Expression is high in both fetal and newborn testis but minimal in testis of 7-day-old animals. Not detected in testis of 21-day-old or adult. Ref.8
Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain
By similarity.
Sequence similarities: Contains 5 cadherin domains.
Research Articles on Cdh3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-Cdh3 antibody
Pathways associated with anti-Cdh3 antibody
Diseases associated with anti-Cdh3 antibody
Organs/Tissues associated with anti-Cdh3 antibody
|