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anti-L1 antibody :: Mouse PAPILLOMAVIRUS 16 L1 LATE PROTEIN Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS211850 anti-L1 antibody
Unit / Price
0.1 mg  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAPILLOMAVIRUS 16 L1 LATE PROTEIN, Monoclonal Antibody

 Also Known As   

MOUSE ANTI PAPILLOMAVIRUS 16 L1 LATE PROTEIN

 Product Gene Name   

anti-L1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P03101
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    CamVir-1
 Host    Mouse
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 Specificity    Reacts with a late protein of HPV type 16. Can be used to detect HPV in human biopsies and smears. HPV-6 and -11 positive biopsies gave negative results.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    Amino acids 198-531 of HPV 16-L1 fused to beta-galactosidase.
Buffer Solution
 Target Species    Viral
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-L1 antibody

   Reacts with a late protein of HPV type 16. Can be used to detect HPV in human biopsies and smears. HPV-6 and -11 positive biopsies gave negative results.
 Applications Tested/Suitable for anti-L1 antibody   

Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistology Paraffin, Western Blot (WB)

 Application Notes for anti-L1 antibody    Western Blot: Detects a 56 kDa band corresponding to the L1 protein. It also detects a 41 kDa protein in uninfected mammalian cells. This unwanted specificity is absent in IPPT/IHC.
Immunohistology: Paraffin embedded, acetone or paraformaldehyde fixed sections are suitable.
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NCBI/Uniprot data below describe general gene information for L1. It may not necessarily be applicable to this product.
 NCBI GI #    9627108
 NCBI GeneID    1489082
 NCBI Accession #    NP_041332.1 [Other Products]
 NCBI GenBank Nucleotide #    NC_001526.2 [Other Products]
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 UniProt Primary Accession #    P03101 [Other Products]
 UniProt Secondary Accession #    O00530 [Other Products]
 UniProt Related Accession #    P03101 [Other Products]
 Molecular Weight    59,474 Da [Similar Products]
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 NCBI Official Full Name    major capsid L1 protein
 NCBI Official Symbol    L1 [Similar Products]
 NCBI Protein Information    major capsid L1 protein
 UniProt Protein Name    Major capsid protein L1
 Protein Family    Packaging protein
 UniProt Gene Name    L1 [Similar Products]
 UniProt Entry Name    VL1_HPV16
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 UniProt Comments for L1    Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
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 Research Articles on L1    1. The expression of HPV-16 L1 was low in cases of advanced high-grade squamous intraepithelial lesions, and cervical cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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