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anti-F2RL1 antibody :: Mouse anti-Human PAR2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS601417 anti-F2RL1 antibody
Unit / Price
100 Tests  /  $685 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAR2 (F2RL1), Monoclonal Antibody

★Popular Item★
 Also Known As   

PAR2 (Proteinase Activated Receptor 2) (PE)

 Product Synonym Names    Anti -PAR2 (Proteinase Activated Receptor 2) (PE)
 Product Gene Name   

anti-F2RL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (76114833..76131140). Location: 5q13
 OMIM    600933
 3D Structure    ModBase 3D Structure for P55085
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    7H40
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human PAR2.
 Purity/Purification    Purified
Purified
 Form/Format    Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
 Concentration    0.05 mg/ml (lot specific)
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 Immunogen    NS0 mouse myeloma cell line transfected with human PAR2, Accession # P55085
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 Preparation and Storage    May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C. Stable for 12 months at 4 degree C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
 Other Notes    Small volumes of anti-F2RL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-F2RL1 antibody

   Human protease-activated receptor 2 (PAR2) is one of 4 members in a unique subclass of the Class A G protein- coupled receptor superfamily. Receptor activation involves the proteolytic uncovering of a cryptic N-terminus receptor sequence that forms a tethered ligand and binds to the receptors within the extracellular loop 2. This activates the receptors to initiate multiple signaling cascades. In addition, short peptides (5-6 amino acids) synthesized based on the proteolytically revealed motif can activate the receptors without the cleavage by enzymes. PAR2 is activated by trypsin and trypsin-like enzymes, and the cleavage site has been identified at residue Arg 36. PAR2 plays an important role in the regulation of cardiovascular, gastrointestinal, and skin function. PAR2 is expressed in human vascular tissues, pancreas, kidney, colon, liver, small intestine, and some tumor cell lines (1, 2).
 Product Categories/Family for anti-F2RL1 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-F2RL1 antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-F2RL1 antibody    Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: Use 10ul to label 1x10e5 cells or 50ul of packed whole blood.
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NCBI/Uniprot data below describe general gene information for F2RL1. It may not necessarily be applicable to this product.
 NCBI GI #    34577052
 NCBI GeneID    2150
 NCBI Accession #    NP_005233.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005242.4 [Other Products]
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 UniProt Primary Accession #    P55085 [Other Products]
 UniProt Secondary Accession #    Q13317; Q13346 [Other Products]
 UniProt Related Accession #    P55085; Q53XJ8 [Other Products]
 Molecular Weight    44,126 Da [Similar Products]
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 NCBI Official Full Name    proteinase-activated receptor 2
 NCBI Official Synonym Full Names    coagulation factor II (thrombin) receptor-like 1
 NCBI Official Symbol    F2RL1 [Similar Products]
 NCBI Official Synonym Symbols   
PAR2; GPR11
[Similar Products]
 NCBI Protein Information    proteinase-activated receptor 2; PAR-2; OTTHUMP00000128315; thrombin receptor-like 1; G protein-coupled receptor-11; G-protein coupled receptor 11; protease-activated receptor 2; proteinase-activated receptor-2; coagulation factor II receptor-like 1
 UniProt Protein Name    Proteinase-activated receptor 2
 UniProt Synonym Protein Names   
Coagulation factor II receptor-like 1; G-protein coupled receptor 11; Thrombin receptor-like 1
 Protein Family    Proteinase-activated receptor
 UniProt Gene Name    F2RL1 [Similar Products]
 UniProt Synonym Gene Names    GPR11; PAR2 [Similar Products]
 UniProt Entry Name    PAR2_HUMAN
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 NCBI Summary for F2RL1    Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq]
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 UniProt Comments for F2RL1    F2RL1: a G-protein coupled receptor for trypsin and trypsin-like enzymes. Acts as a sensor for proteolytic enzymes generated during infection. Modulates pro-inflammatory responses, and innate and adaptive immunity. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. Activates several signaling molecules including phospholipase C (PLC), mitogen-activated protein kinase (MAPK), IKK/NFkB and Rho. Elevates intracellular calcium. Can also be transactivated by cleaved PAR1. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha- 12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, may signal through G(i) subunit alpha. Believed to be a class B receptor that internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram- positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: Golgi apparatus; integral to plasma membrane; early endosome; plasma membrane; pseudopodium

Molecular Function: G-protein coupled receptor activity; protein binding; G-protein alpha-subunit binding; G-protein beta-subunit binding; receptor activity; receptor binding; thrombin receptor activity

Biological Process: negative regulation of JNK cascade; positive regulation of positive chemotaxis; positive regulation of cytokine secretion during immune response; positive regulation of JNK cascade; positive regulation of leukocyte chemotaxis; positive regulation of vasodilation; regulation of JNK cascade; negative regulation of toll-like receptor 3 signaling pathway; T cell activation during immune response; elevation of cytosolic calcium ion concentration; positive regulation of glomerular filtration; positive regulation of superoxide release; interleukin-1 beta secretion; inflammatory response; regulation of I-kappaB kinase/NF-kappaB cascade; defense response to virus; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; neutrophil activation; positive regulation of actin filament depolymerization; positive regulation of chemotaxis; positive regulation of eosinophil degranulation; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of Rho protein signal transduction; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; G-protein coupled receptor protein signaling pathway; positive regulation of pseudopodium formation; regulation of blood coagulation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; positive regulation of phagocytosis, engulfment; leukocyte migration; positive regulation of cell migration
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 Research Articles on F2RL1    1. PAR(2)-dependent calcium signaling was shown to be critical for p42/p44 MAPKinase activation in hepatocellular carcinoma cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-F2RL1 antibodyDiseases associated with anti-F2RL1 antibody
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Disease Name  Pubmed Publications
 Intestinal Diseases Antibodies  >2 publications with F2RL1 and Intestinal Diseases
 Colitis Antibodies  >1 publications with F2RL1 and Colitis
 Obstetric Labor, Premature Antibodies  >1 publications with F2RL1 and Obstetric Labor, Premature
 Fibrosis Antibodies  >1 publications with F2RL1 and Fibrosis
Organs/Tissues associated with anti-F2RL1 antibody
 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >1 publications with F2RL1 and Uterus
 Pancreas Antibodies  >1 publications with F2RL1 and Pancreas
 Intestine Antibodies  >1 publications with F2RL1 and Intestine
 Brain Antibodies  >1 publications with F2RL1 and Brain
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