NP_000306.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
parathyroid hormone preproprotein
NCBI Official Synonym Full Names
parathyroid hormone
NCBI Official Synonym Symbols
NCBI Protein Information
parathyroid hormone; parathormone; parathyrin; parathyroid hormone 1; prepro-PTH; preproparathyroid hormone
UniProt Protein Name
Parathyroid hormone
UniProt Synonym Protein Names
Parathormone; Parathyrin
UniProt Synonym Gene Names
UniProt Entry Name
PTHY_HUMAN
NCBI Summary for PTH
The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]
UniProt Comments for PTH
PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family.
Protein type: Secreted, signal peptide; Hormone; Secreted; Apoptosis
Chromosomal Location of Human Ortholog: 11p15.3-p15.1
Cellular Component: extracellular space; extracellular region
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; type 1 parathyroid hormone receptor binding; peptide hormone receptor binding; parathyroid hormone receptor binding; hormone activity
Biological Process: response to drug; transcription from RNA polymerase II promoter; positive regulation of signal transduction; induction of apoptosis by hormones; positive regulation of glycogen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; Rho protein signal transduction; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; positive regulation of glucose import; response to ethanol; response to cadmium ion; response to vitamin D; cAMP metabolic process; cell-cell signaling; regulation of gene expression; response to lead ion; positive regulation of cAMP biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; skeletal development; bone resorption
Disease: Hypoparathyroidism, Familial Isolated
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Products associated with anti-PTH antibody
Pathways associated with anti-PTH antibody
Diseases associated with anti-PTH antibody
Organs/Tissues associated with anti-PTH antibody
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