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anti-PARP antibody :: Mouse anti-Human PARP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850008
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PARP, Monoclonal Antibody

 Also Known As   

PARP Antibody

 Product Synonym Names    PARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1; PARP1
 Product Gene Name   

anti-PARP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173870
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 Clonality    Monoclonal
 Clone Number    7A10
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Synthetic peptide of human PARP, conjugated to KLH.
 Species    Mouse IgG1
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at -20 degree C.
 Other Notes    Small volumes of anti-PARP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PARP antibody

   Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
 Product Categories/Family for anti-PARP antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-PARP antibody   

Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-PARP antibody    WB: 1/500 - 1/2000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000
Not yet tested in other applications.
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 Testing Data of anti-PARP antibody    Figure 1: Western blot analysis using PARP mouse mAb against Jurkat (1), K562 (2), Hela (3), Raji (4),THP-1 (5) and SW620 (6) cell lysate.
anti-PARP antibody Testing Data image
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 Testing Data #2 of anti-PARP antibody    Figure 2: Flow cytometric analysis of Jurkat cells using anti-PARP mAb (green) and negative control (purple).
anti-PARP antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for PARP. It may not necessarily be applicable to this product.
 NCBI GI #    156523968
 NCBI GeneID    142
 NCBI Accession #    NP_001609.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001618.3 [Other Products]
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 UniProt Secondary Accession #    Q8IUZ9; B1ANJ4 [Other Products]
 UniProt Related Accession #    P09874 [Other Products]
 Molecular Weight    117kDa
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 NCBI Official Full Name    poly
 NCBI Official Synonym Full Names    poly (ADP-ribose) polymerase 1
 NCBI Official Symbol    PARP1 [Similar Products]
 NCBI Official Synonym Symbols   
PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1
[Similar Products]
 NCBI Protein Information    poly [ADP-ribose] polymerase 1; poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthase 1; poly(ADP-ribosyl)transferase; ADP-ribosyltransferase NAD(+); NAD(+) ADP-ribosyltransferase 1; poly (ADP-ribose) polymerase family, member 1; ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
 UniProt Protein Name    Poly [ADP-ribose] polymerase 1
 UniProt Synonym Protein Names   
ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1
 Protein Family    PARP-type zinc finger-containing protein
 UniProt Gene Name    PARP1 [Similar Products]
 UniProt Synonym Gene Names    ADPRT; PPOL; PARP-1; ARTD1; ADPRT 1 [Similar Products]
 UniProt Entry Name    PARP1_HUMAN
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 NCBI Summary for PARP    This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PARP    PARP1: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LRIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423. Interacts (when poly-ADP- ribosylated) with CHD1L. Interacts with the DNA polymerase alpha catalytic subunit POLA1; this interaction functions as part of the control of replication fork progression. Interacts with EEF1A1, RNF4 and TXK.

Protein type: Nuclear receptor co-regulator; DNA repair, damage; Transferase; EC 2.4.2.30; Nuclear envelope; Nucleolus

Chromosomal Location of Human Ortholog: 1q41-q42

Cellular Component: nucleoplasm; transcription factor complex; membrane; nucleolus; nuclear envelope; nucleus

Molecular Function: identical protein binding; protein binding; enzyme binding; DNA binding; zinc ion binding; protein N-terminus binding; transcription factor binding; protein kinase binding; NAD binding; NAD+ ADP-ribosyltransferase activity

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; macrophage differentiation; transcription, DNA-dependent; DNA damage response, detection of DNA damage; negative regulation of transcription from RNA polymerase II promoter; DNA repair; protein autoprocessing; protein amino acid ADP-ribosylation; cellular response to insulin stimulus; base-excision repair; transforming growth factor beta receptor signaling pathway; double-strand break repair; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of growth rate; telomere maintenance
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 Research Articles on PARP    1. the identification of PARP-1 autopoly(ADP-ribosyl)ation sites
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to PARP Antibody
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 MBS8508623  Cleaved-PARP antibody  MBS2538063  Cleaved-PARP-1 (D214) Polyclonal Antibody
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 MBS2516393  PARP3 Polyclonal Antibody  MBS629387  PARP1, NT (Poly [ADP-ribose] Polymerase 1, PARP-1, NAD(+) ADP-ribosyltransferase 1, Poly[ADP-ribose]...
Products associated with anti-PARP antibodyPathways associated with anti-PARP antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >272 publications with PARP and CASP3
 XRCC1 antibody  >83 publications with PARP and XRCC1
 CASP7 antibody  >35 publications with PARP and CASP7
 TP53 antibody  >32 publications with PARP and TP53
 CDKN1A antibody  >27 publications with PARP and CDKN1A
 PCNA antibody  >25 publications with PARP and PCNA
 PRKDC antibody  >18 publications with PARP and PRKDC
 RELA antibody  >14 publications with PARP and RELA
 XRCC5 antibody  >5 publications with PARP and XRCC5
 XRCC6 antibody  >3 publications with PARP and XRCC6
 Products by Pathway  Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway antibodies  Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
Diseases associated with anti-PARP antibodyOrgans/Tissues associated with anti-PARP antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >163 publications with PARP and Breast Neoplasms
 Necrosis Antibodies  >150 publications with PARP and Necrosis
 Inflammation Antibodies  >99 publications with PARP and Inflammation
 Nervous System Diseases Antibodies  >98 publications with PARP and Nervous System Diseases
 Lung Neoplasms Antibodies  >55 publications with PARP and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >51 publications with PARP and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >49 publications with PARP and Neoplasms, Experimental
 Liver Diseases Antibodies  >38 publications with PARP and Liver Diseases
 Prostatic Neoplasms Antibodies  >30 publications with PARP and Prostatic Neoplasms
 Liver Neoplasms Antibodies  >30 publications with PARP and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >139 publications with PARP and Blood
 Brain Antibodies  >105 publications with PARP and Brain
 Lung Antibodies  >103 publications with PARP and Lung
 Liver Antibodies  >68 publications with PARP and Liver
 Vascular Antibodies  >47 publications with PARP and Vascular
 Muscle Antibodies  >43 publications with PARP and Muscle
 Prostate Antibodies  >42 publications with PARP and Prostate
 Skin Antibodies  >40 publications with PARP and Skin
 Kidney Antibodies  >39 publications with PARP and Kidney
 Heart Antibodies  >31 publications with PARP and Heart
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