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anti-PAX-8 antibody :: Mouse anti-Human PAX-8 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS346026
Immunohistochemistry (IHC)
Unit / Price
0.01 mL  /  $170 +1 FREE 8GB USB
0.1 mL  /  $380 +1 FREE 8GB USB
0.2 mL  /  $540 +1 FREE 8GB USB
0.5 mL  /  $1,015 +1 FREE 8GB USB
1 L  /  $1,540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAX-8, Monoclonal Antibody

 Also Known As   

PAX-8 Antibody

 Product Gene Name   

anti-PAX-8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q99573
 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    IHC008
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Liquid
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 Buffer    Tris Buffer, ph7.4, 1% BSA, <0.1% NaN3
 IHC Positive Control    Ovarian, Thyroid, and Renal Cell Carcinomas
 IHC Suggested Protocol    1. Tissues are fixed with 10% neutral buffered formalin, cut to ~4um, and placed on a positively charged glass slide.
2. The prepared slide is baked for at least 30 minutes and at most 24 hours at 55-65 degree C.
3. Pretreatment - Perform heat-induced epitope retrieval (HIER) at pH 6 for 10 to 30 minutes.
4. Block Block with peroxidase solution for 5 minutes at RT.
5. Primary Ab Dilute antibodies 1:100 1:200 and incubate for 10 - 30 minutes at RT.
6. Secondary Ab - Incubate for 20 - 30 minutes at RT.
7. Substrate - Incubate DAB or Fast Red for 5 - 10 minutes at RT.
8. Counterstain - Counterstain with hematoxylin for 30 seconds to 5 minutes, rinse with distilled water and blueing solution for 30 seconds.
9. Dehydrate and apply coverslip.
(Each researcher should optimize the protocol for their experimental model system.)
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 Preparation and Storage    Store at 2-8 degree C. Do not freeze.
 Other Notes    Small volumes of anti-PAX-8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PAX-8 antibody

   PAX-8 is a transcription factor in the paired box (PAX) family, whose mainly functions as important regulators in early development, especially in thyroid follicular cells and thyroid specific genes. Mutations in PAX-8 could lead to thyroid follicular carcinoams, atypical thyroid adenomas, and thyroid dysgenesis. Studies have associated PAX-8 expression with renal carcinoma, nephroblastoma, and seminoma, and have indicated PAX-8 as a useful marker for renal epithelial tumors, ovarian cancer, and for differential diagnoses in lung and neck tumors.
 Applications Tested/Suitable for anti-PAX-8 antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-PAX-8 antibody    Dilution Range: 1:100 - 1:200
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 Immunohistochemistry (IHC) of anti-PAX-8 antibody    IHC (paraffin) of human thyroid gland using PAX-8 Antibody
anti-PAX-8 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PAX-8. It may not necessarily be applicable to this product.
 NCBI GI #    1850829
 NCBI GeneID    7849
 NCBI Accession #    CAA67903.1 [Other Products]
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 UniProt Primary Accession #    Q99573 [Other Products]
 UniProt Related Accession #    Q06710 [Other Products]
 Molecular Weight    6,524 Da
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 NCBI Official Full Name    Pax-8, partial
 NCBI Official Synonym Full Names    paired box 8
 NCBI Official Symbol    PAX8 [Similar Products]
 NCBI Protein Information    paired box protein Pax-8
 UniProt Protein Name    Pax-8 protein
 UniProt Synonym Protein Names   
Pax-8 protein
 UniProt Gene Name    Pax-8 [Similar Products]
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 NCBI Summary for PAX-8    This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
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 Research Articles on PAX-8    1. PAX8-PPARG fusions may not play major roles in the tumorigenesis of paediatric follicular thyroid carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PAX-8 antibody
 Products by Pathway  Pathway Diagram
 Human Thyroid Stimulating Hormone (TSH) Signaling Pathway antibodies  Human Thyroid Stimulating Hormone (TSH) Signaling Pathway Diagram
 ID Signaling Pathway antibodies  ID Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Thyroid Cancer Pathway antibodies  Thyroid Cancer Pathway Diagram
 Thyroid Cancer Pathway antibodies  Thyroid Cancer Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
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