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anti-PBEF1 antibody :: Mouse anti-Human PBEF1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS533077
Western Blot
Unit / Price
0.1 mL  /  $395 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PBEF1, Monoclonal Antibody

 Also Known As   

PBEF1 antibody

 Product Synonym Names    Monoclonal PBEF1; Anti-PBEF1; NAMPT; Pre-B-Cell Colony Enhancing Factor 1; PBEF; DKFZP666B131; MGC117256; PBEF-1; PBEF 1; PBEF1; 1110035O14Rik
 Product Gene Name   

anti-PBEF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608764
 3D Structure    ModBase 3D Structure for P43490
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1D3A12
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    PBEF1 catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
 Immunogen    PBEF1 antibody was raised in Mouse using a purified recombinant fragment of PBEF1(aa338-479) expressed in E Coli as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-PBEF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PBEF1 antibody

   Mouse monoclonal PBEF1 antibody
 Product Categories/Family for anti-PBEF1 antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-PBEF1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-PBEF1 antibody    ELISA: 1:10,000
WB: 1:500-1:2000
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 Western Blot of anti-PBEF1 antibody    Western Blot analysis using PBEF1 antibody
Western Blot showing PBEF1 antibody used against truncated PBEF1-His recombinant protein (1) and full-length GFP-PBEF1 (aa1-491) transfected COS7 cell lysate (2).
anti-PBEF1 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for PBEF1. It may not necessarily be applicable to this product.
 NCBI GI #    51095157
 NCBI GeneID    10135
 NCBI Accession #    EAL24400.1 [Other Products]
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 UniProt Primary Accession #    P43490 [Other Products]
 UniProt Secondary Accession #    Q3KQV0; Q8WW95; A4D0Q9; A4D0R0 [Other Products]
 UniProt Related Accession #    P43490 [Other Products]
 Molecular Weight    55,521 Da
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 NCBI Official Full Name    pre-B-cell colony enhancing factor 1
 NCBI Official Synonym Full Names    nicotinamide phosphoribosyltransferase
 NCBI Official Symbol    NAMPT [Similar Products]
 NCBI Official Synonym Symbols   
VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik
[Similar Products]
 NCBI Protein Information    nicotinamide phosphoribosyltransferase
 UniProt Protein Name    Nicotinamide phosphoribosyltransferase
 UniProt Synonym Protein Names   
Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin
 UniProt Gene Name    NAMPT [Similar Products]
 UniProt Synonym Gene Names    PBEF; PBEF1; NAmPRTase; Nampt; Pre-B cell-enhancing factor [Similar Products]
 UniProt Entry Name    NAMPT_HUMAN
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 NCBI Summary for PBEF1    This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
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 UniProt Comments for PBEF1    PBEF: an ubiquitous protein originally described as a cytokine which acts on early B-lineage precursor cells. Other reports indicate that PBEF is not a cytokine-like secreted protein but an intracellular protein associated with the cell cycle. Contains a catalytically active nicotinate phosphoribosyltransferase domain, an enzyme involved in nicotinamide adenine dinucleotide (NAD) biosynthesis.

Protein type: Cytokine; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.2.12; Transferase; Cell cycle regulation

Chromosomal Location of Human Ortholog: 7q22.3

Cellular Component: extracellular space; cytosol; nucleus

Molecular Function: protein binding; protein homodimerization activity; cytokine activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity; drug binding; nicotinamide phosphoribosyltransferase activity

Biological Process: circadian rhythm; NAD biosynthetic process; vitamin metabolic process; cell-cell signaling; NAD metabolic process; nicotinamide metabolic process; positive regulation of smooth muscle cell proliferation; positive regulation of cell proliferation; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; female pregnancy; circadian regulation of gene expression; signal transduction; response to organic cyclic substance; water-soluble vitamin metabolic process; positive regulation of nitric-oxide synthase biosynthetic process
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 Research Articles on PBEF1    1. NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PBEF1 antibodyPathways associated with anti-PBEF1 antibody
 Reference Product  PubMed Publications
 SIRT1 antibody  >93 publications with PBEF1 and SIRT1
 CLOCK antibody  >21 publications with PBEF1 and CLOCK
 ARNTL antibody  >7 publications with PBEF1 and ARNTL
 IL6 antibody  >3 publications with PBEF1 and IL6
 INS antibody  >3 publications with PBEF1 and INS
 LEP antibody  >2 publications with PBEF1 and LEP
 ITLN1 antibody  >1 publications with PBEF1 and ITLN1
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 NAD Salvage Pathway antibodies  NAD Salvage Pathway Diagram
 Nicotinamide Salvaging Pathway antibodies  Nicotinamide Salvaging Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
Diseases associated with anti-PBEF1 antibodyOrgans/Tissues associated with anti-PBEF1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >82 publications with PBEF1 and Inflammation
 Obesity Antibodies  >70 publications with PBEF1 and Obesity
 Insulin Resistance Antibodies  >50 publications with PBEF1 and Insulin Resistance
 Disease Models, Animal Antibodies  >25 publications with PBEF1 and Disease Models, Animal
 Necrosis Antibodies  >23 publications with PBEF1 and Necrosis
 Liver Diseases Antibodies  >20 publications with PBEF1 and Liver Diseases
 Atherosclerosis Antibodies  >20 publications with PBEF1 and Atherosclerosis
 Nervous System Diseases Antibodies  >18 publications with PBEF1 and Nervous System Diseases
 Fatty Liver Antibodies  >14 publications with PBEF1 and Fatty Liver
 Heart Diseases Antibodies  >13 publications with PBEF1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >100 publications with PBEF1 and Blood
 Adipose Tissue Antibodies  >46 publications with PBEF1 and Adipose Tissue
 Muscle Antibodies  >41 publications with PBEF1 and Muscle
 Liver Antibodies  >40 publications with PBEF1 and Liver
 Vascular Antibodies  >33 publications with PBEF1 and Vascular
 Brain Antibodies  >26 publications with PBEF1 and Brain
 Heart Antibodies  >24 publications with PBEF1 and Heart
 Connective Tissue Antibodies  >24 publications with PBEF1 and Connective Tissue
 Lung Antibodies  >16 publications with PBEF1 and Lung
 Bone Antibodies  >13 publications with PBEF1 and Bone
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