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anti-PBEF1 antibody :: Mouse anti-Human PBEF1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850071
Testing Data
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PBEF1, Monoclonal Antibody

 Also Known As   

PBEF1 Antibody

 Product Synonym Names    VF; PBEF; PBEF1; VISFATIN; NAMPT
 Product Gene Name   

anti-PBEF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608764
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 Clonality    Monoclonal
 Clone Number    1D3A12
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of PBEF1 (aa338-479) expressed in E. Coli.
 Species    Mouse IgG1
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 Preparation and Storage    Store at 4 degree C. For long term storage, store at -20 degree C
 Other Notes    Small volumes of anti-PBEF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PBEF1 antibody

   Background: PBEF1. nicotinamide phosphoribosyltransferase. This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
 Product Categories/Family for anti-PBEF1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-PBEF1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-PBEF1 antibody    WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000
Not yet tested in other applications. Determining optimal working dilutions by titration test.
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 Testing Data of anti-PBEF1 antibody    Figure 1. Western blot analysis using PBEF1 mouse mAb against truncated PBEF1-His recombinant protein (1) and full-length GFP-PBEF1(aa1-491) transfected COS7 cell lysate (2).
anti-PBEF1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for PBEF1. It may not necessarily be applicable to this product.
 NCBI GI #    5031977
 NCBI GeneID    10135
 NCBI Accession #    NP_005737.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005746.2 [Other Products]
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 UniProt Secondary Accession #    Q3KQV0; Q8WW95; A4D0Q9; A4D0R0 [Other Products]
 UniProt Related Accession #    P43490 [Other Products]
 Molecular Weight    55,521 Da
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 NCBI Official Full Name    nicotinamide phosphoribosyltransferase
 NCBI Official Synonym Full Names    nicotinamide phosphoribosyltransferase
 NCBI Official Symbol    NAMPT [Similar Products]
 NCBI Official Synonym Symbols   
VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik
[Similar Products]
 NCBI Protein Information    nicotinamide phosphoribosyltransferase; NAmPRTase; pre-B cell-enhancing factor; pre-B-cell colony enhancing factor 1; pre-B-cell colony-enhancing factor 1
 UniProt Protein Name    Nicotinamide phosphoribosyltransferase
 UniProt Synonym Protein Names   
Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin
 UniProt Gene Name    NAMPT [Similar Products]
 UniProt Synonym Gene Names    PBEF; PBEF1; NAmPRTase; Nampt; Pre-B cell-enhancing factor [Similar Products]
 UniProt Entry Name    NAMPT_HUMAN
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 NCBI Summary for PBEF1    This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
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 UniProt Comments for PBEF1    PBEF: an ubiquitous protein originally described as a cytokine which acts on early B-lineage precursor cells. Other reports indicate that PBEF is not a cytokine-like secreted protein but an intracellular protein associated with the cell cycle. Contains a catalytically active nicotinate phosphoribosyltransferase domain, an enzyme involved in nicotinamide adenine dinucleotide (NAD) biosynthesis.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Transferase; Cell cycle regulation; EC 2.4.2.12; Cytokine

Chromosomal Location of Human Ortholog: 7q22.3

Cellular Component: extracellular space; cytosol; nucleus

Molecular Function: protein binding; protein homodimerization activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity; cytokine activity; drug binding; nicotinamide phosphoribosyltransferase activity

Biological Process: circadian rhythm; vitamin metabolic process; positive regulation of smooth muscle cell proliferation; female pregnancy; signal transduction; response to organic cyclic substance; NAD biosynthetic process; cell-cell signaling; nicotinamide metabolic process; NAD metabolic process; positive regulation of cell proliferation; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; water-soluble vitamin metabolic process; positive regulation of nitric-oxide synthase biosynthetic process
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 Research Articles on PBEF1    1. the correlations of visfatin/Nampt, vaspin, and RBP-4 with insulin resistance are tissue dependent.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PBEF1 antibodyPathways associated with anti-PBEF1 antibody
 Reference Product  PubMed Publications
 SIRT1 antibody  >82 publications with PBEF1 and SIRT1
 RETN antibody  >5 publications with PBEF1 and RETN
 IL1B antibody  >3 publications with PBEF1 and IL1B
 INS antibody  >3 publications with PBEF1 and INS
 LEP antibody  >2 publications with PBEF1 and LEP
 LPL antibody  >2 publications with PBEF1 and LPL
 IL6 antibody  >2 publications with PBEF1 and IL6
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
Diseases associated with anti-PBEF1 antibodyOrgans/Tissues associated with anti-PBEF1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >74 publications with PBEF1 and Inflammation
 Necrosis Antibodies  >23 publications with PBEF1 and Necrosis
 Disease Models, Animal Antibodies  >21 publications with PBEF1 and Disease Models, Animal
 Atherosclerosis Antibodies  >19 publications with PBEF1 and Atherosclerosis
 Liver Diseases Antibodies  >17 publications with PBEF1 and Liver Diseases
 Fatty Liver Antibodies  >13 publications with PBEF1 and Fatty Liver
 Nervous System Diseases Antibodies  >13 publications with PBEF1 and Nervous System Diseases
 Weight Loss Antibodies  >9 publications with PBEF1 and Weight Loss
 Heart Diseases Antibodies  >8 publications with PBEF1 and Heart Diseases
 Neoplasms, Experimental Antibodies  >7 publications with PBEF1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >87 publications with PBEF1 and Blood
 Adipose Tissue Antibodies  >41 publications with PBEF1 and Adipose Tissue
 Muscle Antibodies  >37 publications with PBEF1 and Muscle
 Liver Antibodies  >35 publications with PBEF1 and Liver
 Vascular Antibodies  >30 publications with PBEF1 and Vascular
 Connective Tissue Antibodies  >24 publications with PBEF1 and Connective Tissue
 Brain Antibodies  >21 publications with PBEF1 and Brain
 Heart Antibodies  >18 publications with PBEF1 and Heart
 Lung Antibodies  >15 publications with PBEF1 and Lung
 Bone Antibodies  >13 publications with PBEF1 and Bone
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