NP_000430.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,010 Da
NCBI Official Full Name
neuroendocrine convertase 1 isoform 1 preproprotein
NCBI Official Synonym Full Names
proprotein convertase subtilisin/kexin type 1
NCBI Protein Information
neuroendocrine convertase 1; prohormone convertase 1; prohormone convertase 3
UniProt Protein Name
Neuroendocrine convertase 1
UniProt Synonym Protein Names
Prohormone convertase 1; Proprotein convertase 1; PC1
UniProt Synonym Gene Names
UniProt Entry Name
NEC1_HUMAN
NCBI Summary for PCSK1
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]
UniProt Comments for PCSK1
PCSK1: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Belongs to the peptidase S8 family. Furin subfamily.
Protein type: EC 3.4.21.93; Protease
Chromosomal Location of Human Ortholog: 5q15-q21
Cellular Component: Golgi apparatus; extracellular space; transport vesicle
Molecular Function: serine-type endopeptidase activity
Biological Process: cellular protein metabolic process; cell-cell signaling; metabolic process; peptide hormone processing; proteolysis; regulation of insulin secretion; peptide biosynthetic process
Disease: Proprotein Convertase 1/3 Deficiency; Body Mass Index Quantitative Trait Locus 12
Research Articles on PCSK1
Precautions
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Products associated with anti-PCSK1 antibody
Pathways associated with anti-PCSK1 antibody
Products by Pathway |
Pathway Diagram |
Incretin Synthesis, Secretion, And Inactivation Pathway antibodies |
Incretin Synthesis, Secretion, And Inactivation Pathway Diagram |
Insulin Processing Pathway antibodies |
Insulin Processing Pathway Diagram |
Metabolism Of Proteins Pathway antibodies |
Metabolism Of Proteins Pathway Diagram |
Peptide Hormone Biosynthesis Pathway antibodies |
Peptide Hormone Biosynthesis Pathway Diagram |
Peptide Hormone Metabolism Pathway antibodies |
Peptide Hormone Metabolism Pathway Diagram |
Synthesis, Secretion, And Deacylation Of Ghrelin Pathway antibodies |
Synthesis, Secretion, And Deacylation Of Ghrelin Pathway Diagram |
Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway antibodies |
Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway Diagram |
Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway antibodies |
Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway Diagram |
Diseases associated with anti-PCSK1 antibody
Organs/Tissues associated with anti-PCSK1 antibody
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