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| Product Name
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PCSK9 , Monoclonal Antibody ★Popular Item★
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| Also Known As
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Rabbit anti Human PCSK9 Monoclonal Antibody
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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AX127530 mRNA
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| Clonality
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Monoclonal
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| Isotype
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IgG
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| Host
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Rabbit
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| Species Reactivity
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Human
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| Immunogen
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Recombinant Human PCSK9 protein
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| Buffer
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PBS with 0.05% sodium azide, 30% glycerol
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| Produce
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This antibody was obtained from a rabbit immunized with purified, recombinant Human PCSK9
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| Preparation and Storage
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Store at -20 degree C. Avoid freeze / thaw cycles
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| ISO Certification
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Manufactured in an ISO 9001:2008 Certified Laboratory.
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| Other Notes
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Small volumes of anti-PCSK9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
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| Applications Tested/Suitable for anti-PCSK9 antibody
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ELISA (EIA)
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| Application Notes for anti-PCSK9 antibody
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ELISA 1:1000-1:2000
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TOP
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| NCBI/Uniprot data below describe general gene information for PCSK9 . It may not necessarily be applicable to this product. |
| NCBI GI #
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31317307
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| NCBI GeneID
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255738
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| NCBI GenBank Nucleotide #
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NM_174936.3
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[Other Products]
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| UniProt Secondary Accession #
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Q5PSM5; Q5SZQ2; A8T640; C0JYY9
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[Other Products]
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| UniProt Related Accession #
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Q8NBP7
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[Other Products]
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TOP
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| NCBI Official Full Name
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proprotein convertase subtilisin/kexin type 9 preproprotein
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| NCBI Official Synonym Full Names
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proprotein convertase subtilisin/kexin type 9
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| NCBI Official Symbol
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PCSK9
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[Similar Products]
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| NCBI Official Synonym Symbols
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FH3; PC9; NARC1; LDLCQ1; NARC-1; HCHOLA3
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[Similar Products]
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| NCBI Protein Information
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proprotein convertase subtilisin/kexin type 9
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| UniProt Protein Name
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Proprotein convertase subtilisin/kexin type 9
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| UniProt Synonym Protein Names
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Neural apoptosis-regulated convertase 1; NARC-1; Proprotein convertase 9; PC9; Subtilisin/kexin-like protease PC9
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| UniProt Gene Name
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PCSK9
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[Similar Products]
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| UniProt Synonym Gene Names
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NARC1; NARC-1; PC9
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[Similar Products]
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| UniProt Entry Name
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PCSK9_HUMAN
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| NCBI Summary for PCSK9
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This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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| UniProt Comments for PCSK9
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PCSK9: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. Defects in PCSK9 are the cause of hypercholesterolemia autosomal dominant type 3 (HCHOLA3). A familial condition characterized by elevated circulating cholesterol contained in either low-density lipoproteins alone or also in very-low-density lipoproteins. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: cell surface; cytoplasm; early endosome; endoplasmic reticulum; extracellular space; extrinsic to external side of plasma membrane; Golgi apparatus; late endosome; lysosome; perinuclear region of cytoplasm; plasma membrane
Molecular Function: apolipoprotein binding; apolipoprotein receptor binding; low-density lipoprotein binding; low-density lipoprotein receptor binding; protein binding; protein self-association; receptor inhibitor activity; serine-type endopeptidase activity; sodium channel inhibitor activity; very-low-density lipoprotein binding
Biological Process: cellular response to insulin stimulus; cellular response to starvation; cholesterol homeostasis; kidney development; liver development; low-density lipoprotein receptor catabolic process; lysosomal transport; negative regulation of receptor recycling; neurogenesis; neuron differentiation; positive regulation of low-density lipoprotein receptor catabolic process; positive regulation of neuron apoptosis; positive regulation of receptor internalization; protein autoprocessing; regulation of neuron apoptosis; regulation of receptor activity
Disease: Hypercholesterolemia, Autosomal Dominant, 3
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TOP
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| Research Articles on PCSK9
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1. In this study, variants in PCSK9 had approximately the same effect as variants in HMGCR on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive.
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with anti-PCSK9 antibody | Pathways associated with anti-PCSK9 antibody |
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| Diseases associated with anti-PCSK9 antibody | Organs/Tissues associated with anti-PCSK9 antibody |
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Antibody 
