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anti-PCSK9  antibody :: Rabbit anti-Human PCSK9  Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2544039 anti-PCSK9  antibody
Unit / Price
0.06 mL  /  $215 +1 FREE 8GB USB
0.12 mL  /  $330 +1 FREE 8GB USB
0.2 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PCSK9 , Monoclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti Human PCSK9  Monoclonal Antibody

 Product Gene Name   

anti-PCSK9  antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AX127530 mRNA
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 Clonality    Monoclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Immunogen    Recombinant Human PCSK9 protein
 Buffer    PBS with 0.05% sodium azide, 30% glycerol
 Produce    This antibody was obtained from a rabbit immunized with purified, recombinant Human PCSK9
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PCSK9  antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PCSK9  antibody

   Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
 Applications Tested/Suitable for anti-PCSK9  antibody   

ELISA (EIA)

 Application Notes for anti-PCSK9  antibody    ELISA 1:1000-1:2000
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NCBI/Uniprot data below describe general gene information for PCSK9 . It may not necessarily be applicable to this product.
 NCBI GI #    31317307
 NCBI GeneID    255738
 NCBI GenBank Nucleotide #    NM_174936.3 [Other Products]
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 UniProt Secondary Accession #    Q5PSM5; Q5SZQ2; A8T640; C0JYY9 [Other Products]
 UniProt Related Accession #    Q8NBP7 [Other Products]
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 NCBI Official Full Name    proprotein convertase subtilisin/kexin type 9 preproprotein
 NCBI Official Synonym Full Names    proprotein convertase subtilisin/kexin type 9
 NCBI Official Symbol    PCSK9 [Similar Products]
 NCBI Official Synonym Symbols   
FH3; PC9; NARC1; LDLCQ1; NARC-1; HCHOLA3
[Similar Products]
 NCBI Protein Information    proprotein convertase subtilisin/kexin type 9
 UniProt Protein Name    Proprotein convertase subtilisin/kexin type 9
 UniProt Synonym Protein Names   
Neural apoptosis-regulated convertase 1; NARC-1; Proprotein convertase 9; PC9; Subtilisin/kexin-like protease PC9
 UniProt Gene Name    PCSK9 [Similar Products]
 UniProt Synonym Gene Names    NARC1; NARC-1; PC9 [Similar Products]
 UniProt Entry Name    PCSK9_HUMAN
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 NCBI Summary for PCSK9     This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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 UniProt Comments for PCSK9     PCSK9: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. Defects in PCSK9 are the cause of hypercholesterolemia autosomal dominant type 3 (HCHOLA3). A familial condition characterized by elevated circulating cholesterol contained in either low-density lipoproteins alone or also in very-low-density lipoproteins. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p32.3

Cellular Component: cell surface; cytoplasm; early endosome; endoplasmic reticulum; extracellular space; extrinsic to external side of plasma membrane; Golgi apparatus; late endosome; lysosome; perinuclear region of cytoplasm; plasma membrane

Molecular Function: apolipoprotein binding; apolipoprotein receptor binding; low-density lipoprotein binding; low-density lipoprotein receptor binding; protein binding; protein self-association; receptor inhibitor activity; serine-type endopeptidase activity; sodium channel inhibitor activity; very-low-density lipoprotein binding

Biological Process: cellular response to insulin stimulus; cellular response to starvation; cholesterol homeostasis; kidney development; liver development; low-density lipoprotein receptor catabolic process; lysosomal transport; negative regulation of receptor recycling; neurogenesis; neuron differentiation; positive regulation of low-density lipoprotein receptor catabolic process; positive regulation of neuron apoptosis; positive regulation of receptor internalization; protein autoprocessing; regulation of neuron apoptosis; regulation of receptor activity

Disease: Hypercholesterolemia, Autosomal Dominant, 3
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 Research Articles on PCSK9     1. In this study, variants in PCSK9 had approximately the same effect as variants in HMGCR on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PCSK9  antibodyPathways associated with anti-PCSK9  antibody
 Reference Product  PubMed Publications
 LDLR antibody  >481 publications with PCSK9  and LDLR
 APOB antibody  >282 publications with PCSK9  and APOB
 VLDLR antibody  >14 publications with PCSK9  and VLDLR
 HNF1A antibody  >10 publications with PCSK9  and HNF1A
 ANXA2 antibody  >5 publications with PCSK9  and ANXA2
 INS antibody  >1 publications with PCSK9  and INS
 Products by Pathway  Pathway Diagram
 Evolocumab Mechanism Pathway antibodies  Evolocumab Mechanism Pathway Diagram
 LDL-mediated Lipid Transport Pathway antibodies  LDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Mediated LDL Receptor Degradation Pathway antibodies  Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Mediated LDL Receptor Degradation Pathway Diagram
 VLDL Interactions Pathway antibodies  VLDL Interactions Pathway Diagram
 VLDLR Internalisation And Degradation Pathway antibodies  VLDLR Internalisation And Degradation Pathway Diagram
Diseases associated with anti-PCSK9  antibodyOrgans/Tissues associated with anti-PCSK9  antibody
 Disease Name  Pubmed Publications
 Hypercholesterolemia Antibodies  >752 publications with PCSK9  and Hypercholesterolemia
 Dyslipidemias Antibodies  >643 publications with PCSK9  and Dyslipidemias
 Hyperlipidemias Antibodies  >536 publications with PCSK9  and Hyperlipidemias
 Atherosclerosis Antibodies  >389 publications with PCSK9  and Atherosclerosis
 Heart Diseases Antibodies  >197 publications with PCSK9  and Heart Diseases
 Coronary Artery Disease Antibodies  >134 publications with PCSK9  and Coronary Artery Disease
 Myocardial Infarction Antibodies  >61 publications with PCSK9  and Myocardial Infarction
 Liver Diseases Antibodies  >57 publications with PCSK9  and Liver Diseases
 Inflammation Antibodies  >54 publications with PCSK9  and Inflammation
 Insulin Resistance Antibodies  >40 publications with PCSK9  and Insulin Resistance
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >264 publications with PCSK9  and Liver
 Brain Antibodies  >34 publications with PCSK9  and Brain
 Intestine Antibodies  >29 publications with PCSK9  and Intestine
 Connective Tissue Antibodies  >9 publications with PCSK9  and Connective Tissue
 Skin Antibodies  >7 publications with PCSK9  and Skin
 Embryonic Tissue Antibodies  >5 publications with PCSK9  and Embryonic Tissue
 Pancreas Antibodies  >4 publications with PCSK9  and Pancreas
 Bone Antibodies  >3 publications with PCSK9  and Bone
 Ovary Antibodies  >3 publications with PCSK9  and Ovary
 Stomach Antibodies  >2 publications with PCSK9  and Stomach
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