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anti-PDGFRA/CD140a antibody :: Mouse anti-Human PDGFRA/CD140a Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2543424 anti-PDGFRA/CD140a antibody
Unit / Price
0.06 mL  /  $215 +1 FREE 8GB USB
0.12 mL  /  $330 +1 FREE 8GB USB
0.2 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDGFRA/CD140a, Monoclonal Antibody

 Also Known As   

Mouse anti Human PDGFRA/CD140a Monoclonal Antibody

 Product Gene Name   

anti-PDGFRA/CD140a antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M22734 mRNA
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 Clonality    Monoclonal
 Isotype    IgG2a
 Host    Mouse
 Species Reactivity    Human
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 Immunogen    Recombinant Human PDGFRA/CD140a protein
 Buffer    0.2 mum filtered solution in PBS with 5% trehalose
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 Preparation and Storage    This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-PDGFRA/CD140a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PDGFRA/CD140a antibody   

Western Blot (WB)

 Application Notes for anti-PDGFRA/CD140a antibody    WB: 20-50 mug/ml
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NCBI/Uniprot data below describe general gene information for PDGFRA/CD140a. It may not necessarily be applicable to this product.
 NCBI GI #    5453870
 NCBI GeneID    5156
 NCBI GenBank Nucleotide #    NM_006206.5 [Other Products]
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 UniProt Secondary Accession #    Q6P4H5; Q96KZ7; Q9UD28; B2RE69; E9PBH0 [Other Products]
 UniProt Related Accession #    P16234 [Other Products]
 Molecular Weight    82,809 Da
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 NCBI Official Full Name    platelet-derived growth factor receptor alpha isoform 1
 NCBI Official Synonym Full Names    platelet derived growth factor receptor alpha
 NCBI Official Symbol    PDGFRA [Similar Products]
 NCBI Official Synonym Symbols   
CD140A; PDGFR2; PDGFR-2
[Similar Products]
 NCBI Protein Information    platelet-derived growth factor receptor alpha
 UniProt Protein Name    Platelet-derived growth factor receptor alpha
 UniProt Synonym Protein Names   
Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; PDGFR-2; CD_antigen: CD140a
 UniProt Gene Name    PDGFRA [Similar Products]
 UniProt Synonym Gene Names    PDGFR2; RHEPDGFRA; PDGF-R-alpha; PDGFR-alpha; PDGFR-2 [Similar Products]
 UniProt Entry Name    PGFRA_HUMAN
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 NCBI Summary for PDGFRA/CD140a    This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
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 UniProt Comments for PDGFRA/CD140a    PDGFRA: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation. Particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. Chromosomal rearrangments activate PDGFRalpha by fusion to BCR, causing atypical chronic myelogenous leukemia (CML), and to FIP1L1, causing idiopathic hypereosinophilic syndrome. Activating point mutations cause a minority of gastrointestinal stromal tumors (GIST). Promoter polymorphisms linked to neural tube defects including spina bifida, verified by mouse mutant model. Inhibitors: Gleevec, Sutent. OMIM: Two alternatively-spliced isoforms have been described.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: cytoplasm; integral to plasma membrane; intrinsic to plasma membrane; membrane; nucleus; plasma membrane; protein complex

Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein binding; protein homodimerization activity; protein kinase activity; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity

Biological Process: cardiac myofibril assembly; cell activation; elevation of cytosolic calcium ion concentration; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic skeletal morphogenesis; luteinization; MAPKKK cascade; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of fibroblast proliferation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; protein amino acid autophosphorylation; regulation of chemotaxis; regulation of phosphoinositide 3-kinase cascade; wound healing

Disease: Gastrointestinal Stromal Tumor; Hypereosinophilic Syndrome, Idiopathic
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 Research Articles on PDGFRA/CD140a    1. Ku80 and PDGFR-alpha might be effective predictive indicators for the prognosis of nasal type NK/T cell lymphoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Mouse anti Human PDGFRA/CD140a Monoclonal Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS2543424  Mouse anti Human PDGFRA/CD140a Monoclonal Antibody  MBS2543422  Mouse anti Human PDGFRA/CD140a Monoclonal Antibody
 MBS2543423  Mouse anti Human PDGFRa/CD140a Monoclonal Antibody
Products associated with anti-PDGFRA/CD140a antibodyPathways associated with anti-PDGFRA/CD140a antibody
 Reference Product  PubMed Publications
 PDGFRB antibody  >204 publications with PDGFRA/CD140a and PDGFRB
 PDGFA antibody  >25 publications with PDGFRA/CD140a and PDGFA
 PDGFB antibody  >22 publications with PDGFRA/CD140a and PDGFB
 PDGFC antibody  >9 publications with PDGFRA/CD140a and PDGFC
 PIK3R1 antibody  >8 publications with PDGFRA/CD140a and PIK3R1
 GRB2 antibody  >3 publications with PDGFRA/CD140a and GRB2
 CAV1 antibody  >2 publications with PDGFRA/CD140a and CAV1
 PLCG1 antibody  >2 publications with PDGFRA/CD140a and PLCG1
 CRK antibody  >2 publications with PDGFRA/CD140a and CRK
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
Diseases associated with anti-PDGFRA/CD140a antibodyOrgans/Tissues associated with anti-PDGFRA/CD140a antibody
 Disease Name  Pubmed Publications
 Gastrointestinal Stromal Tumors Antibodies  >646 publications with PDGFRA/CD140a and Gastrointestinal Stromal Tumors
 Hypereosinophilic Syndrome Antibodies  >271 publications with PDGFRA/CD140a and Hypereosinophilic Syndrome
 Lung Diseases Antibodies  >49 publications with PDGFRA/CD140a and Lung Diseases
 Lung Neoplasms Antibodies  >46 publications with PDGFRA/CD140a and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >39 publications with PDGFRA/CD140a and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >36 publications with PDGFRA/CD140a and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >28 publications with PDGFRA/CD140a and Liver Neoplasms
 Hyperplasia Antibodies  >28 publications with PDGFRA/CD140a and Hyperplasia
 Heart Diseases Antibodies  >27 publications with PDGFRA/CD140a and Heart Diseases
 Neoplasms, Experimental Antibodies  >25 publications with PDGFRA/CD140a and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >238 publications with PDGFRA/CD140a and Blood
 Bone Antibodies  >169 publications with PDGFRA/CD140a and Bone
 Stomach Antibodies  >149 publications with PDGFRA/CD140a and Stomach
 Brain Antibodies  >146 publications with PDGFRA/CD140a and Brain
 Bone Marrow Antibodies  >117 publications with PDGFRA/CD140a and Bone Marrow
 Muscle Antibodies  >108 publications with PDGFRA/CD140a and Muscle
 Lung Antibodies  >82 publications with PDGFRA/CD140a and Lung
 Vascular Antibodies  >77 publications with PDGFRA/CD140a and Vascular
 Liver Antibodies  >71 publications with PDGFRA/CD140a and Liver
 Intestine Antibodies  >71 publications with PDGFRA/CD140a and Intestine
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