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anti-PEG10 antibody :: anti-Human PEG10 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS475079
Unit / Price
0.1 mL  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PEG10, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-PEG10 Mouse mAb

 Product Synonym Names    AA407948; Edr; Embryonal carcinoma differentiation regulated; Embryonal carcinoma differentiation-regulated protein; HB 1; HB1; KIAA1051; Mammalian retrotransposon-derived protein 2; Mar2; Mart2; MEF3 like 1; MEF3-like protein 1; MEF3L; MEF3L1; MyEF 3; Myelin expression factor 3-like protein 1; Paternally expressed 10; Paternally expressed gene 10 ORF1; Paternally expressed gene 10 protein; Peg10; PEG10 protein; PEG10_HUMAN; Putative uncharacterized protein PEG10; Retrotransposon gag domain containing 3; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Retrotransposon-derived protein PEG10; RGAG3; Ty3/Gypsy-like protein
 Product Gene Name   

anti-PEG10 antibody

[Similar Products]
 Product Synonym Gene Name    EDR; HB-1; Mar2; MEF3L; Mart2; RGAG3 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AB049834 mRNA
 3D Structure    ModBase 3D Structure for Q86TG7
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1E2-F12-C12
 Host    Mouse
Source: Human
 Species Reactivity    Human
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 Purity/Purification    Affinity Purified
 Form/Format    Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%, glycerol
 Concentration    1mg/ml (lot specific)
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 Immunogen    Purified recombinant human PEG10 protein fragments expressed in E Coli.
 Sensitivity    This antibody detects endogenous levels of PEG10 and does not cross-react with related proteins.
 Sequence Similarities    Contains 1 CCHC-type zinc finger.
 Subunit Structure    Interacts with ALK1, SIAH1 and SIAH2.
 Subcellular Location    Nucleus. Cytoplasm
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 Other Notes    Small volumes of anti-PEG10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PEG10 antibody

   Entrez Summary: This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. [provided by RefSeq, May 2010]
 Product Categories/Family for anti-PEG10 antibody    Stem Cells; Germline Stem Cells; Spermatogonial Stem Cells; Cancer; Oncoproteins/suppressors; Viral proteins; Retrovirus
 Applications Tested/Suitable for anti-PEG10 antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-PEG10 antibody    WB: 1:1000
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 Western Blot (WB) of anti-PEG10 antibody    Western blot detection of PEG10 in Hela cell lysates using PEG10 mouse mAb (1:1000 diluted).Predicted band size:55KDa.Observed band size:55KDa, 95KDa.
anti-PEG10 antibody Western Blot (WB) (WB) image
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 Immunoprecipitation (IP) of anti-PEG10 antibody    Immunoprecipitation analysis of Hela cell lysates using PEG10 mouse mAb.
anti-PEG10 antibody Immunoprecipitation (IP) (IP) image
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NCBI/Uniprot data below describe general gene information for PEG10. It may not necessarily be applicable to this product.
 NCBI GI #    94421473
 NCBI GeneID    23089
 NCBI Accession #    NP_001035242.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040152 [Other Products]
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 UniProt Primary Accession #    Q86TG7 [Other Products]
 UniProt Secondary Accession #    Q96A68; Q9UPV1 [Other Products]
 UniProt Related Accession #    Q86TG7 [Other Products]
 Molecular Weight    55
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 NCBI Official Full Name    retrotransposon-derived protein PEG10 isoform 2
 NCBI Official Synonym Full Names    paternally expressed 10
 NCBI Official Symbol    PEG10 [Similar Products]
 NCBI Official Synonym Symbols   
EDR; HB-1; Mar2; MEF3L; Mart2; RGAG3
[Similar Products]
 NCBI Protein Information    retrotransposon-derived protein PEG10
 UniProt Protein Name    Retrotransposon-derived protein PEG10
 UniProt Synonym Protein Names   
Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein
 Protein Family    Retrotransposon-derived protein
 UniProt Gene Name    PEG10 [Similar Products]
 UniProt Synonym Gene Names    EDR; KIAA1051; MAR2; MART2; MEF3L1; RGAG3; MEF3-like protein 1 [Similar Products]
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 NCBI Summary for PEG10    This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]
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 UniProt Comments for PEG10    PEG10: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter. Up-regulated by MYC and dihydrotestosteron (DHT). Interacts with ALK1, SIAH1 and SIAH2. 2 isoforms of the human protein are produced by ribosomal frameshifting.

Protein type: Apoptosis; Cell cycle regulation; Cell development/differentiation; RNA-binding

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of transforming growth factor beta receptor signaling pathway
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 Research Articles on PEG10    1. Knockdown of PEG10 expression by siRNA could lead to growth arrest and cell apoptosis in diffuse large B cell lymphoma cells in vitro.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PEG10 antibodyPathways associated with anti-PEG10 antibody
 Reference Product  PubMed Publications
 SGCE antibody  >19 publications with PEG10 and SGCE
 PEG3 antibody  >18 publications with PEG10 and PEG3
 CCR7 antibody  >3 publications with PEG10 and CCR7
 DLX6 antibody  >2 publications with PEG10 and DLX6
 SIAH1 antibody  >2 publications with PEG10 and SIAH1
 MYC antibody  >1 publications with PEG10 and MYC
 Products by Pathway  Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram
Diseases associated with anti-PEG10 antibodyOrgans/Tissues associated with anti-PEG10 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >21 publications with PEG10 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >21 publications with PEG10 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >20 publications with PEG10 and Liver Diseases
 Liver Neoplasms Antibodies  >18 publications with PEG10 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with PEG10 and Neoplasms, Experimental
 Uterine Neoplasms Antibodies  >3 publications with PEG10 and Uterine Neoplasms
 Embryo Loss Antibodies  >3 publications with PEG10 and Embryo Loss
 Breast Neoplasms Antibodies  >2 publications with PEG10 and Breast Neoplasms
 Kidney Diseases Antibodies  >2 publications with PEG10 and Kidney Diseases
 Inflammation Antibodies  >2 publications with PEG10 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >30 publications with PEG10 and Placenta
 Liver Antibodies  >26 publications with PEG10 and Liver
 Embryonic Tissue Antibodies  >19 publications with PEG10 and Embryonic Tissue
 Brain Antibodies  >11 publications with PEG10 and Brain
 Kidney Antibodies  >5 publications with PEG10 and Kidney
 Lung Antibodies  >4 publications with PEG10 and Lung
 Umbilical Cord Antibodies  >4 publications with PEG10 and Umbilical Cord
 Nerve Antibodies  >4 publications with PEG10 and Nerve
 Mammary Gland Antibodies  >3 publications with PEG10 and Mammary Gland
 Muscle Antibodies  >3 publications with PEG10 and Muscle
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