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anti-PLAA antibody :: Mouse PLAA Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2542029
Western Blot (WB)
Unit / Price
0.06 mL  /  $220 +1 FREE 8GB USB
0.12 mL  /  $290 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PLAA, Monoclonal Antibody

 Also Known As   

PLAA Monoclonal Antibody

 Product Synonym Names    FLJ11281; FLJ12699; Glycerophosphatase; OTTHUMP00000045176; Phospholipase A 2 activating protein; Phospholipase A-2-activating protein; Phospholipase A2 activating protein; PLA2P; Plaa; PLAP; PLAP
 Product Gene Name   

anti-PLAA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603873 gene
 3D Structure
   ModBase 3D Structure for Q9Y263
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    555
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Protein A purification
 Concentration    1mg/mL (lot specific)
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 Immunogen    Fusion protein of PLAA
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, PH7.3
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PLAA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PLAA antibody

   Phospholipase A-2-activating protein (PLAA), also named PLAP, can interact with ubiquitin and is involved in the maintenance of ubiquitin levels. PLAA contains multiple consensus domains including WD repeats, PFU domain and PUL domain. Although the function of PLAA remains unclear, ubiquitin binding of PLAA might be the central role that connects ubiquitination and degradation in ERAD. Recent finding revealed that PLAA served as a novel nociveptive mediator after incision, and its expression level is regulated by miR-203.
 Product Categories/Family for anti-PLAA antibody    Immunology
 Applications Tested/Suitable for anti-PLAA antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-PLAA antibody    WB: 1:500-1:5000
IHC: 1:50-1:500
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 Western Blot (WB) of anti-PLAA antibody    Western Blot analysis of ROS1728 cells using PLAA Monoclonal Antibody at dilution of 1:1000
anti-PLAA antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PLAA. It may not necessarily be applicable to this product.
 NCBI GI #    72534670
 NCBI GeneID    9373
 NCBI Accession #    NP_001026859.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001031689.2 [Other Products]
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 UniProt Primary Accession #    Q9Y263 [Other Products]
 UniProt Secondary Accession #    Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y5L1 [Other Products]
 UniProt Related Accession #    Q9Y263 [Other Products]
 Molecular Weight    Calculated: 81kDa
Observed: 72-74kDa
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 NCBI Official Full Name    phospholipase A-2-activating protein isoform 1
 NCBI Official Synonym Full Names    phospholipase A2 activating protein
 NCBI Official Symbol    PLAA [Similar Products]
 NCBI Official Synonym Symbols   
DOA1; PLAP; PLA2P; NDMSBA
[Similar Products]
 NCBI Protein Information    phospholipase A-2-activating protein
 UniProt Protein Name    Phospholipase A-2-activating protein
 Protein Family    Phospholipase A-2-activating protein
 UniProt Gene Name    PLAA [Similar Products]
 UniProt Synonym Gene Names    PLAP; PLA2P; PLAP [Similar Products]
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 UniProt Comments for PLAA    Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).
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 Research Articles on PLAA    1. In both human and mouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysfunction syndrome with seizures.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLAA antibodyPathways associated with anti-PLAA antibody
 Reference Product  PubMed Publications
 PDIA3 antibody  >3 publications with PLAA and PDIA3
 VCP antibody  >2 publications with PLAA and VCP
 CAV1 antibody  >1 publications with PLAA and CAV1
 Products by Pathway  Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with anti-PLAA antibodyOrgans/Tissues associated with anti-PLAA antibody
 Disease Name  Pubmed Publications
 Poisoning Antibodies  >62 publications with PLAA and Poisoning
 Drug-Induced Liver Injury Antibodies  >48 publications with PLAA and Drug-Induced Liver Injury
 Liver Diseases Antibodies  >47 publications with PLAA and Liver Diseases
 Nervous System Diseases Antibodies  >17 publications with PLAA and Nervous System Diseases
 Necrosis Antibodies  >13 publications with PLAA and Necrosis
 Neurotoxicity Syndromes Antibodies  >10 publications with PLAA and Neurotoxicity Syndromes
 Disease Models, Animal Antibodies  >8 publications with PLAA and Disease Models, Animal
 Kidney Diseases Antibodies  >8 publications with PLAA and Kidney Diseases
 Lung Diseases Antibodies  >5 publications with PLAA and Lung Diseases
 Inflammation Antibodies  >5 publications with PLAA and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >145 publications with PLAA and Liver
 Blood Antibodies  >93 publications with PLAA and Blood
 Kidney Antibodies  >20 publications with PLAA and Kidney
 Lung Antibodies  >12 publications with PLAA and Lung
 Brain Antibodies  >12 publications with PLAA and Brain
 Vascular Antibodies  >8 publications with PLAA and Vascular
 Muscle Antibodies  >4 publications with PLAA and Muscle
 Adipose Tissue Antibodies  >4 publications with PLAA and Adipose Tissue
 Bone Antibodies  >4 publications with PLAA and Bone
 Connective Tissue Antibodies  >4 publications with PLAA and Connective Tissue
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