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anti-PLAP antibody :: Rabbit anti-Human PLAP (Placental Alkaline Phosphatase) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS684024
Testing Data
Unit / Price
1 ml (Prediluted)  /  $175 +1 FREE 8GB USB
0.04 mL  /  $185 +1 FREE 8GB USB
0.1 mL  /  $275 +1 FREE 8GB USB
7 ml (Prediluted)  /  $285 +1 FREE 8GB USB
0.2 mL  /  $340 +1 FREE 8GB USB
0.5 mL  /  $415 +1 FREE 8GB USB
1 mL  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PLAP (Placental Alkaline Phosphatase), Monoclonal Antibody

 Also Known As   

Anti - PLAP (Placental Alkaline Phosphatase)

 Product Gene Name   

anti-PLAP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.12 (232378534..232382889). Location: 2q37
 OMIM    171800
 3D Structure    ModBase 3D Structure for P05187
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 Clonality    Monoclonal
 Clone Number    P16-D
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human
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 Immunogen    Peptide derived from the middle portion of human PLAP sequence
 Storage Buffer    20 mM Tris-HCI, pH 8.0
 Stabilizer    20 mg/ml BSA
 Preservative    0.05% NaN3
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 Preparation and Storage    Store at +4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
 Other Notes    Small volumes of anti-PLAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PLAP antibody   

Immunohistochemistry (IHC) - Formalin/Paraffin

 Application Notes for anti-PLAP antibody    IHC-P dilution 1:100 - 1:200; IHC-Fr application and dilution to be tested by the user
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 Testing Data of anti-PLAP antibody    anti-PLAP antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for PLAP. It may not necessarily be applicable to this product.
 NCBI GI #    130737
 NCBI GeneID    250
 NCBI Accession #    P05187.2 [Other Products]
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 UniProt Primary Accession #    P05187 [Other Products]
 UniProt Secondary Accession #    P05188; P06861; Q53S78; Q96DB7 [Other Products]
 UniProt Related Accession #    P05187 [Other Products]
 Molecular Weight    57,954 Da
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 NCBI Official Full Name    Alkaline phosphatase, placental type
 NCBI Official Synonym Full Names    alkaline phosphatase, placental
 NCBI Official Symbol    ALPP [Similar Products]
 NCBI Official Synonym Symbols   
ALP; PALP; PLAP; PLAP-1
[Similar Products]
 NCBI Protein Information    alkaline phosphatase, placental type; Regan isozyme; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme
 UniProt Protein Name    Alkaline phosphatase, placental type
 UniProt Synonym Protein Names   
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1
 Protein Family    Probable low-affinity putrescine importer
 UniProt Gene Name    ALPP [Similar Products]
 UniProt Synonym Gene Names    PLAP; PLAP-1 [Similar Products]
 UniProt Entry Name    PPB1_HUMAN
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 NCBI Summary for PLAP    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PLAP    Catalytic activity: A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor: Binds 1 magnesium ion

By similarity.Binds 2 zinc ions

By similarity.

Subunit structure: Homodimer.

Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor Ref.10 Ref.11.

Polymorphism: Placental ALP is highly polymorphic, there are at least three common alleles.

Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).

Sequence similarities: Belongs to the alkaline phosphatase family.

Sequence caution: The sequence AAA51708.1 differs from that shown. Reason: Erroneous initiation.
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 Research Articles on PLAP    1. Data indicate that p180 is required for the efficient targeting of placental alkaline phosphatase (ALPP) mRNA to the endoplasmic reticulum (ER).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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