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anti-PLEK antibody :: Mouse anti-Human PLEK Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2541363
Western Blot (WB)
Unit / Price
0.06 mL  /  $220 +1 FREE 8GB USB
0.12 mL  /  $290 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PLEK, Monoclonal Antibody

 Also Known As   

PLEK Monoclonal Antibody

 Product Synonym Names    FLJ27168; OTTHUMP00000159962; p47; Platelet 47 kDa protein; Platelet and leukocyte C kinase substrate; Platelet P47; Platelet p47 protein; Pleckstrin; PLEK; PLEK
 Product Gene Name   

anti-PLEK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    More" target="_blank" rel="nofollow">173570 gene
 3D Structure    ModBase 3D Structure for P08567
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1D5C2
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Protein G purification
 Concentration    1mg/mL (lot specific)
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 Immunogen    Fusion protein of PLEK
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, PH7.3
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PLEK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PLEK antibody

   PLEK (pleckstrin; also known as p47) was originally identified as the major PKC substrate in platelets and later is found to be expressed in all cells of the hemopoietic system. Through two pleckstrin homology (PH) domains at its N and C termini, PLEK may interact with various protein and/or lipid ligands and serve as an intracellular adaptor/targeting protein. Predominantly cytosolic in unstimulated cells, PLEK would undergo transient redistribution to phagosomal membrane in response to stimuli. PLEK has been found to be hyperphosphorylated in diabetic mononuclear phagocytes and promote proinflammatory cytokine secretion in diabetes. (10477609, 17579087)
 Product Categories/Family for anti-PLEK antibody    Cancer; Cardiovascular; Signal transduction
 Applications Tested/Suitable for anti-PLEK antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-PLEK antibody    WB: 1:2000-1:20000
IHC: 1:50-1:500
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 Western Blot (WB) of anti-PLEK antibody    Western Blot analysis of HL-60 cells using PLEK Monoclonal Antibody at dilution of 1:5000
anti-PLEK antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PLEK. It may not necessarily be applicable to this product.
 NCBI GI #    156616273
 NCBI GeneID    5341
 NCBI Accession #    NP_002655.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002664.2 [Other Products]
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 UniProt Primary Accession #    P08567 [Other Products]
 UniProt Secondary Accession #    Q53SU8; Q6FGM8; Q6FGQ1; Q8WV81; B2R9E8 [Other Products]
 UniProt Related Accession #    P08567 [Other Products]
 Molecular Weight    Calculated: 40kDa
Observed: 40-47kDa
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 NCBI Official Full Name    pleckstrin
 NCBI Official Synonym Full Names    pleckstrin
 NCBI Official Symbol    PLEK [Similar Products]
 NCBI Official Synonym Symbols   
P47
[Similar Products]
 NCBI Protein Information    pleckstrin
 UniProt Protein Name    Pleckstrin
 UniProt Synonym Protein Names   
Platelet 47 kDa protein; p47
 Protein Family    Pleckstrin
 UniProt Gene Name    PLEK [Similar Products]
 UniProt Synonym Gene Names    P47; p47 [Similar Products]
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 UniProt Comments for PLEK    Major protein kinase C substrate of platelets.
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 Research Articles on PLEK    1. Only one gene, pleckstrin , was significantly overexpressed in periodontitis,cardiovascular disease, rheumatoid arthritis and ulcerative colitis , implicating this gene as an important networking link between these chronic inflammatory diseases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PLEK antibodyDiseases associated with anti-PLEK antibody
 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with PLEK and Inflammation
 Skin Diseases Antibodies  >1 publications with PLEK and Skin Diseases
 Hypertension Antibodies  >1 publications with PLEK and Hypertension
 Edema Antibodies  >1 publications with PLEK and Edema
Organs/Tissues associated with anti-PLEK antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with PLEK and Blood
 Lung Antibodies  >3 publications with PLEK and Lung
 Heart Antibodies  >2 publications with PLEK and Heart
 Mammary Gland Antibodies  >1 publications with PLEK and Mammary Gland
 Bone Antibodies  >1 publications with PLEK and Bone
 Vascular Antibodies  >1 publications with PLEK and Vascular
 Ovary Antibodies  >1 publications with PLEK and Ovary
 Eye Antibodies  >1 publications with PLEK and Eye
 Spleen Antibodies  >1 publications with PLEK and Spleen
 Brain Antibodies  >1 publications with PLEK and Brain
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