NP_001166170.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 3
NCBI Official Synonym Full Names
PPARG coactivator 1 beta
NCBI Official Synonym Symbols
PERC; ERRL1; PGC1B; PGC-1(beta) [Similar Products]
NCBI Protein Information
peroxisome proliferator-activated receptor gamma coactivator 1-beta
UniProt Protein Name
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
UniProt Synonym Protein Names
PGC-1-related estrogen receptor alpha coactivator
UniProt Synonym Gene Names
PERC; PGC1; PGC1B; PPARGC1; PGC-1-beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta [Similar Products]
NCBI Summary for PPARGC1B
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for PPARGC1B
PGC-1 beta: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: nucleoplasm; nucleus; Srb-mediator complex
Molecular Function: AF-2 domain binding; estrogen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; receptor activator activity; transcription factor binding
Biological Process: estrogen receptor signaling pathway; mitochondrion organization and biogenesis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent
Disease: Obesity
Research Articles on PPARGC1B
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Products associated with anti-PPARGC1B antibody
Pathways associated with anti-PPARGC1B antibody
Diseases associated with anti-PPARGC1B antibody
Organs/Tissues associated with anti-PPARGC1B antibody
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