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anti-PPP1CA antibody :: Mouse anti-Human PPP1CA Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200069
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PPP1CA, Monoclonal Antibody

 Also Known As   

PPP1CA antibody

 Product Synonym Names    serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1; protein phosphatase 1 catalytic subunit alpha isozyme; PP-1A; PP1alpha; ppp1a; MGC15877; MGC1674;
 Product Gene Name   

anti-PPP1CA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    X70848 mRNA
 3D Structure    ModBase 3D Structure for P62136
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 Clonality    Monoclonal
 Isotype    IgG2a, k
 Clone Number    4G3
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Immunogen    Recombinant human PPP1CA (30-299aa) purified from E. coli
 Clone Note    Anti-human PPP1CA mAb, clone 4G3, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PPP1CA protein.
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 Preparation and Storage    Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-PPP1CA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PPP1CA antibody

   Protein phosphatase 1, catalytic subunit, alpha isoform, also known as PPP1CA, is one of the three catalytic subunits of protein phosphatase 1. The protein is highly conserved in eukaryotic cells and play a role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. It is participate in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis and apoptosis
 Product Categories/Family for anti-PPP1CA antibody    Signal Transduction
 Applications Tested/Suitable for anti-PPP1CA antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-PPP1CA antibody    WB: 1:500 ~ 2,000.
Recommended starting dilution is 1:1,000.
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 Western Blot (WB) of anti-PPP1CA antibody    Cell lysates of HepG2 (45ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human PPP1CA (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
anti-PPP1CA antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-PPP1CA antibody    ICC/IF analysis of PPP1CA in HeLa cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human PPP1CA antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
anti-PPP1CA antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for PPP1CA. It may not necessarily be applicable to this product.
 NCBI GI #    4506003
 NCBI GeneID    5499
 NCBI Accession #    NP_002699 [Other Products]
 NCBI GenBank Nucleotide #    NM_002708.3 [Other Products]
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 UniProt Primary Accession #    P62136 [Other Products]
 UniProt Secondary Accession #    P08129; P20653; P22802; Q07161; A6NNR3; B2R908 [Other Products]
 UniProt Related Accession #    P62136 [Other Products]
 Molecular Weight    32,595 Da
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 NCBI Official Full Name    serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1
 NCBI Official Synonym Full Names    protein phosphatase 1 catalytic subunit alpha
 NCBI Official Symbol    PPP1CA [Similar Products]
 NCBI Official Synonym Symbols   
PP1A; PP-1A; PPP1A; PP1alpha
[Similar Products]
 NCBI Protein Information    serine/threonine-protein phosphatase PP1-alpha catalytic subunit
 UniProt Protein Name    Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
 Protein Family    Serine/threonine-protein phosphatase
 UniProt Gene Name    PPP1CA [Similar Products]
 UniProt Synonym Gene Names    PPP1A; PP-1A [Similar Products]
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 NCBI Summary for PPP1CA    The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PPP1CA    Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).
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Product References and Citations for anti-PPP1CA antibody

   Cohen PT. (2002) J Cell Sci. 115 (2):241-56; Hsu LC, et al. (2006) Oncogene. 25 (40):5517-26
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 Research Articles on PPP1CA    1. Data suggest that protein phosphatase 1, catalytic subunit, alpha isoform (PPP1CA) is a candidate sero-diagnostic and prognostic marker for badder cancer (BC).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PPP1CA antibodyPathways associated with anti-PPP1CA antibody
 Reference Product  PubMed Publications
 PPP1CC antibody  >10 publications with PPP1CA and PPP1CC
 PPP1CB antibody  >7 publications with PPP1CA and PPP1CB
 PPP1R2 antibody  >1 publications with PPP1CA and PPP1R2
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Rythm Related Genes Pathway antibodies  Circadian Rythm Related Genes Pathway Diagram
Diseases associated with anti-PPP1CA antibodyOrgans/Tissues associated with anti-PPP1CA antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >4 publications with PPP1CA and Brain Diseases
 Lung Neoplasms Antibodies  >3 publications with PPP1CA and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with PPP1CA and Cardiovascular Diseases
 Lung Diseases Antibodies  >2 publications with PPP1CA and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with PPP1CA and Cell Transformation, Neoplastic
 Neoplasm Invasiveness Antibodies  >2 publications with PPP1CA and Neoplasm Invasiveness
 Death Antibodies  >2 publications with PPP1CA and Death
 Neoplasms, Experimental Antibodies  >1 publications with PPP1CA and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with PPP1CA and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with PPP1CA and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >6 publications with PPP1CA and Lung
 Brain Antibodies  >6 publications with PPP1CA and Brain
 Muscle Antibodies  >5 publications with PPP1CA and Muscle
 Prostate Antibodies  >4 publications with PPP1CA and Prostate
 Blood Antibodies  >4 publications with PPP1CA and Blood
 Heart Antibodies  >4 publications with PPP1CA and Heart
 Nerve Antibodies  >4 publications with PPP1CA and Nerve
 Kidney Antibodies  >3 publications with PPP1CA and Kidney
 Stomach Antibodies  >2 publications with PPP1CA and Stomach
 Eye Antibodies  >2 publications with PPP1CA and Eye
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